Showing papers in "Biochemical and Biophysical Research Communications in 1990"

TL;DR: The potent antitumoral activity of celerythrine measured in vitro might be due at least in part to inhibition of PKC and thus suggests that PKC may be a model for rational design of antitumor drugs.

TL;DR: A new peptide of 22 amino acid residues, eliciting a potent relaxant activity on chick rectum is found, the third member to join the natriuretic peptide family and shows a pharmacological spectrum similar to ANP and BNP.

TL;DR: In the LNCaP androgen receptor a single point mutation is discovered changing the sense of codon 868 (Thr to Ala) in the ligand binding domain, which influences both binding and the induction of gene expression by different steroids and antisteroids.

TL;DR: Synthetic PACAP27 which shows a considerable homology with vasoactive intestinal polypeptide (VIP) demonstrated a similar vasodepressor activity as VIP, but the adenylate cyclase stimulating activity was about 1000 times greater than VIP.

TL;DR: It is reported here that electrical field stimulation of isolated strips of rabbit corpus cavernosum promotes the endogenous formation and release of nitric oxide, nitrite, and cyclic GMP, and indicates that penile erection may be mediated by NO generated in response to nonadrenergic-noncholinergic neurotransmission.

TL;DR: Free radicals generated by glycated protein increased peroxidation of membranes of linoleic/arachidonic acid vesicles nearly 2-fold over control, suggesting that the increased glycation of proteins in diabetes may accelerate vascular wall lipid oxidative modification.

TL;DR: In vitro studies in rings of rat thoracic aorta indicate that prevention of the induction of NO synthase by glucocorticoids may be an important component of their therapeutic action.

TL;DR: The utility of nitric oxide synthesis inhibitors in endotoxic shock is demonstrated for the first time and it is suggested that such inhibitors may be of therapeutic value in the treatment of septic shock.

TL;DR: It turned out that bovine serum albumin (BSA) is composed of 583 amino acid residues, and that its average molecular weight is not 66267.1, and it is corrected to 66430.3.

TL;DR: Results indicate that 10T1/2 cells have a potential to differentiate into osteogenic cells under the control of BMP-2.

TL;DR: Part of the anti-inflammatory and immunosuppressive actions of glucocorticoids is due to their inhibition of the induction of the NO synthase, which is suggested to be responsible for the release of NO.

TL;DR: The results suggest that over-expression of GLUT1 and GLUT3 might be closely related with tissue development and that the acceleration of glucose uptake by transformed cells may result, at least in part, from the increase in the expression of these two glucose transporters.

TL;DR: Inhibition of induction of the Ca2(+)-independent NO synthase in vivo may underlie some of the physiological and pharmacological effects of the anti-inflammatory glucocorticoids.

TL;DR: The data indicate that the deiodinase subunit contains one selenium atom per molecule and suggest that a highly reactive selenocysteine is the residue essential for the catalysis of 5'-deiodination.

TL;DR: Lipid peroxidation results have now shown that tocopherols are much stronger membrane antioxidants than naturally occurring ubiquinols (ubiquinones), and direct radical scavenging effects of ubiquinol effects might be negligible in the presence of comparable or higher concentrations of tocop herols.

TL;DR: Results indicate that age-related accumulation of deleted mtDNA is accelerated in the parkinsonian striatum and suggest that the deletion contributes to pathophysiological processes underlying Parkinson's disease.

TL;DR: A human small intestinal lambda gt11 cDNA library was screened with antibodies to deglycosylated small intestinal mucin and four partial cDNA clones were isolated that define a novel human mucin gene.

TL;DR: This work suggests that the mutation in the mitochondrial tRNALeu gene causes MELAS, a major group of heterogeneous mitochondrial disorders.

TL;DR: Sequence analysis of amplified 400 bp cDNA fragments encoding a portion of NS5 gene suggested that HCV can be classified into two types (named K1 and K2) in Japan.

TL;DR: Evidence is presented to indicate that in hepatocytes the morphological changes and effects on the cytoskeleton are due to phosphatase inhibition, and the importance of the protein phosphorylation in maintenance of structural and homeostatic integrity in these cells is indicated.

TL;DR: The effects of 1-methyl-4-phenylpyridinium (MPP+), a metabolite of a parkinsonism-inducing drug, on the superoxide formation and the lipid peroxidation in bovine heart submitochondrial particles are studied.

TL;DR: Cloning of PACAP38 cDNAs confirms the expression of the corresponding mRNAs and the presence of this neuropeptide in ovine hypothalamus and also in human testis.

TL;DR: A high degree of homology is observed with LH/hCG receptor suggesting the definition of a new subfamily of G-protein coupled receptors, similar to that described in the non receptor type protein tyrosine kinases.

TL;DR: HGF is concluded to be synthesized in the Kupffer and endothelial cells to repair the liver tissue in paracrine fashion.

TL;DR: It is reported that L-NG-aminoarginine and L- NG-nitro arginine are about 100-fold more potent than NG-methylarginines in blocking endothelial cell NO and are about equipotent with macrophages whereas NG-Nitroarg inine is much less potent.

TL;DR: Among various phosphate acceptor proteins and peptides so far tested, a synthetic peptide having the sequence surrounding Ser(8) of myelin basic protein, Gln-Lys- Arg-Pro-Ser(8)-Gln-Arg-Ser-Tyr-Leu, (MBP4-14), is the most specific and convenient substrate which can be used for selective assay of protein kinase C.

TL;DR: The cDNA of an unidentified recently cloned G protein-coupled receptor, RDC8, has been expressed in Y1 adrenal cells, in dog thyrocytes in primary culture and in Xenopus oocytes, and this physiologically constitutive activator was inhibited by adenosine deaminase and by inhibitors of the adenosines A2 receptor.

TL;DR: A cDNA clone was isolated that conferred to COS cells the ability to bind a new and highly efficient hydrophilic derivative of N-formyl-Met-Leu-Phe-Lys, a pattern quite similar to that of G protein-coupled receptors.

TL;DR: The results suggested that IL-1, a macrophage-derived cytokine, may affect the contraction and proliferation of vascular smooth muscle cells by stimulating the production of endothelin by endothelial cells.

TL;DR: A cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor is isolated and sequenced, showing sequence similarity to G protein-coupled receptors.