Showing papers in "Biochemical and Biophysical Research Communications in 1995"

TL;DR: 2-Arachidonoylglycerol was shown to bind appreciably to the cannabinoid receptor in competitive inhibition experiments and may be an endogenous cannabinoid receptor ligand in the brain.

TL;DR: The data demonstrate a potent neuroprotective activity of the antioxidant 17-beta estradiol, which may have implications for the prevention and treatment of Alzheimer's disease, and was estrogen receptor-independent.

TL;DR: Sphingosines or sphingosine-1-phosphate are associated with CTLL-2 proliferation, and ISP-1/myriocin suppresses T cell proliferation by the modulation of sphingolipid metabolism.

TL;DR: Investigation of the effect of various non-steroidal anti-inflammatory agents and related compounds on the induction of NO synthase (NOS) in macrophages activated with lipopolysaccharide and interferon-gamma found significantly reduced levels of the mRNA and 130-kDa protein of inducible NOS were expressed in Macrophage activated with curcumin, compared to those withoutCurcumin.

TL;DR: Evidence is provided that NO plays a regulatory role in the activation of metal-dependent proteases in articular chondrocytes and cartilage by inducing metalloprotease activity in a dose-dependent fashion.

TL;DR: It is suggested that NO is a mediator of mechanical effects in bone, leading to enhanced PGE2 release, and the hypothesis that fluid flow through the osteocyte canalicular network provides the physical stimulus for mechanosensation in bone is strengthened.

TL;DR: The results point to a relationship between MRP and a conjugate transporter and identify MK571 as a new tool structure for developing modulators specific for a MRP associated multidrug resistance.

TL;DR: Estrogen increases NOS-3 via a receptor-mediated system, and estrogen receptor, which appeared to be altered by cell senescence, could be important in the release of NO from endothelium.

TL;DR: The results establish that normal skeletal muscle cells can express two constitutive isoforms of NOS (nc- and ec-) and suggest a functional role for ec-NOS in oxidative, mitochondria-rich fibers.

TL;DR: It was found that the flavonoids are very potent .NO scavengers and the anthocyanidins were found to be more effective scavengers than the hydroxyethylrutosides, which correlated with their therapeutic activity.

TL;DR: Northern blot analysis showed that cathepsin K mRNA is expressed at high levels in some osteoarthritic hip bones and at a very high level in osteoclastoma compared to very low levels in other tissues, suggesting that cat hepsinK is closely involved in human osteoclastic bone resorption.

TL;DR: Although BMK1 has the dual phosphorylation site of MAP kinase characterized by the TEY sequence found in ERK1 and ERK2, it has a distinct C-terminal and loop-12 structure when compared to other mammalian MAP kinases, which suggests BMK 1 may regulate signaling events distinct from those controlled by the ERK group of enzymes.

TL;DR: Results suggest that PrP may be a copper binding protein in vivo, and synthetic peptides containing three or four copies of an octapeptide repeat sequence found in a highly conserved N-terminal domain of PrP, preferentially bind copper over other metals.

TL;DR: Results indicate that the precursor form in the cytosol is transferred to the vacuole by autophagy and converted to the active form by vacuolar proteinases, which could be determined easily and accurately by measuring the phosphatase activity.

TL;DR: The results demonstrate that the metabolism of arginine in macrophages is controlled by TH1/TH2-dependent cytokines and suggest a regulatory role of Arginase on the NO synthesis by intracellular substrate depletion.

TL;DR: The attachment and growth of fibroblast cells (L-929) on matrices of silk fibroin from Bombyx mori domestic silkworm and Antheraea pernyi wild silkworm were studied by a cell culture method and WSF, which contains the tripeptide sequence Arg-Gly-Asp, displayed much higher cell attachment andgrowth compared to DSF.

TL;DR: It is shown that the recombinant HCV NS3 protein purified from a T7 promoter and His-tag expression system possesses an RNA helicase activity.

TL;DR: The results suggest that AM secreted from VSMC actually exerts a vasorelaxant effect under physiological conditions such as endotoxin shock, atherosclerosis and inflammation.

TL;DR: The results indicate that the measurement of these compounds in plasma is a valid indicator of NO generation in fasted human volunteers and thus defines the quantitative relationship between the L-arginine:nitric oxide (NO) pathway and the formation of these oxides of nitrogen.

TL;DR: Using CD spectroscopy, the effect of Cu2+ on the secondary structure of synthetic peptides Octa4 and Hexa4 corresponding to tetra-repeats of the octapeptide of mammalian PrP and the hexapeptides of chicken PrP is investigated.

TL;DR: The novel finding that IP-10, a member of the C-X-C chemokine family, is a potent inhibitor of both IL-8 and bFGF-induced angiogenic activity is demonstrated using in vitro and in vivo assays of angiogenesis to support the contention thatIP-10 may be a pivotal cytokine in the regulation of neovascularization.

TL;DR: For the first time, it is shown that plants exposed to UV radiations accumulate proline and proline can protect plant cells against UV radiation induced peroxidative processes.

TL;DR: A novel sequence present downstream of the poly(U) stretch that was previously considered to be the 3' end structure of the HCV genome was discovered, which had no significant homology with any known sequences, viral or nonviral.

TL;DR: This experiment is presented as a first approach to a synthetic minimal cell, in which the reproduction of the membrane and the replication of the internalized RNA molecules proceed simultaneously.

TL;DR: The molecular characterization of the major apple allergen, Mal d 1, is reported and crossreactivity with Bet v 1, the major birch pollen allergenic, was shown by inhibition assays.

TL;DR: In piglets studied on the first day of life transient hypoxia-ischaemia caused an increase in the fractions of necrotic and apoptotic cells in the cingulate sulcus compared to sham-operated controls, and hypothermia specifically inhibited apoptosis.

TL;DR: The detection of a platelet peptide which corresponds to Aβ indicates that, aside from the well-known non-amyloidogenic (secretory) pathway, the processing of APP in platelets from healthy individuals also involves an amyloidsogenic pathway.

TL;DR: A novel synthetic peptide AIP, a nonphosphorylatable analog of autocamtide-2, was found to be a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II) and indicates that AIP is a useful tool for studying the physiological roles of CaM-Kinase II.

TL;DR: It is shown that cell growth arrest correlates with the accumulation of 14α-methyl-ergosta-8,24(28)-dien-3β,6α-diol in a yeast strain with a sterol 14 α-demethylase gene disruption, which mimics stringent treatment conditions.

TL;DR: The results suggest that genetic variation at the ER locus may be associated with some determinants for BMD and bone metabolism in postmenopausal women.