Showing papers in "Biochemical and Biophysical Research Communications in 1997"

TL;DR: It is demonstrated that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes and the nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs.

TL;DR: Results indicate that TTV would be a novel DNA virus with a possible capacity to induce posttransfusion non-A to G hepatitis.

TL;DR: In this paper, the authors showed that mRNA for another H2S producing enzyme, cystathionine gamma-lyase, is expressed in the ileum, portal vein, and thoracic aorta.

TL;DR: The construction and characterization of a series of chimeric recombinases, each consisting of Cre fused to a mutated human oestrogen receptor (ER) ligand-binding domain (LBD) are reported, which should be useful for efficient spatio-temporally controlled site-directed somatic mutagenesis.

TL;DR: Data suggest that OCIF is a novel cytokine which specifically inhibits osteoclastogenesis, and has no homology to known proteins.

TL;DR: The molecular cloning of a third uncoupling protein homologue, designated UCP3, is reported, which is a promising target for anti-obesity drug development aimed at increasing thermogenesis.

TL;DR: DJ-1 showed a cooperative transforming activity with H-Ras, more than 3 times as strong as the activity of ras/myc combination and is suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway.

TL;DR: SAPK3 and SAPK4 form a distinct subset of the p38 MAP kinases with different expression pattern, response to stimuli, substrate specificity, and inhibitor sensitivity.

TL;DR: The concept that NO is an endogenous regulator of caspase activity is supported, with reports that of the seven caspases studied, all were reversibly inhibited by NO.

TL;DR: Several lines of investigation support the idea that DRMs are not detergent-induced artifacts, but exist as domains in cell membranes, and explore the possibility that DRs are present in a phase separate from the surrounding bilayer.

TL;DR: A transgenic mouse line carrying the CAG-cre transgene in which the cre gene is under control of the cytomegalovirus immediate early enhancer-chicken beta-actin hybrid (CAG) promoter is developed, and Cre mRNA and/or protein are retained in mature oocytes irrespective of the transmission of the C AG-cre Transgene, resulting in efficient Cre-mediated recombination of paternally derived target genes upon fertilization.

TL;DR: It is concluded that the Pro12Ala PPARγ2 gene variant is present in diverse populations and further studies of the Pro 12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.

TL;DR: This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss howCa2+ might interact with some of the other biochemical signals implicated in cell death.

TL;DR: It is concluded that IL-1β stimulates PG production via transcriptional activation of COX-2 and evidence that this may involve NF-κB is provided.

TL;DR: RT-PCR indicates that the leptin receptor, Ob-R, and in particular the Ob-Ra splice variant are expressed in a wide range of tissues, but the long form leptin receptor (Ob-Rb) was only expressed at significant levels in the medulla of the adrenal and the inner zone of the medullary of the kidney.

TL;DR: It is concluded that dietary supplementation of carotenoids may act as moderate hypocholesterolemic agents, secondary to their inhibitory effect on macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase, the rate limiting enzyme in cholesterol synthesis.

TL;DR: The present technique provides a simple yet powerful and universal tool for researchers to probe the events of single molecules through objective-type total internal reflection fluorescence microscopy.

TL;DR: Increasing evidence suggests that apoptosis and necrosis seem to represent only different shapes of cell demise, resulting from a more or less complete execution of the internal death program.

TL;DR: Electroporation would provide a useful and efficient nonviral means of foreign gene transfection to somatic cells of living chicken embryos in ovo and suggest that as far as transient gene expression is concerned is concerned.

TL;DR: The peroxynitrite scavenging activity of a series of structurally related flavonoids was tested and indications were found that the catechol group (ring B) and the hydroxyl group at position 3 give the highest contribution to the peroxysine scavenging effect.

TL;DR: The catechin polyphenols were found to offer protection from peroxynitrite-induced modification of critical amino acids of apolipoprotein B-100 of LDL which contribute towards its surface charge.

TL;DR: Common SULT1A1 nucleotide polymorphisms that are associated with phenotypic variation in both platelet TS PST activity and thermal stability are reported, step toward understanding molecular mechanisms responsible for the genetic regulation of PSTs in humans.

TL;DR: NOS III appears to be a superoxide generating enzyme probably through its flavin moiety, as well as a BH4-dependent NO producing enzyme.

TL;DR: Results demonstrate that transcriptional activation through the Sp1 sites of the WAF1/Cip1 promoter by TSA coincides with induced hyperacetylation of histone H4.

TL;DR: It is reported that microinjection of Plk mRNA is sufficient to drive quiescent cells into mitosis and that constitutive expression of PlK in NIH 3T3 cells causes oncogenic focus formation.

TL;DR: It is concluded that Hyal-1 is the predominant hyaluronidase found in human plasma, and stably expressed in human embryonic kidney cells resulted in a 3,000 fold increase of secreted immunoreactive hyalursoridase activity that was biochemically indistinguishable from human plasma hyalurinidase.

TL;DR: Three additional CIS family genes (CIS2, CIS3, and CIS4) are cloned on the basis of an expression sequence tag (EST) database search and could play a role in the negative regulation of cytokine signaling by interacting with specific targets.

TL;DR: Experimental observations suggest that arachidonic acid needs to be metabolized through the 5-lipoxygenase pathway to produce 5-HETE series of eicosatetraenoids for its growth stimulatory effects on human prostate cancer cells.

TL;DR: These in vitro studies suggest an autocrine/paracrine action of leptin on white fat cells and envisages the involvement of the OB protein, not only in centrally mediated pathways, but also in physiological functions which take place peripherally.