Showing papers in "Biochemical and Biophysical Research Communications in 2005"

TL;DR: This study examined by microarray the global expression levels of 245 microRNAs in glioblastoma multiforme, the most frequent and malignant of primary brain tumors, and identified a group of micro RNAs whose expression is significantly altered in this tumor.

TL;DR: A humanized anti-VEGF monoclonal antibody has been approved by the FDA as a first-line treatment for metastatic colorectal cancer in combination with chemotherapy and VEGF is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration.

TL;DR: The biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies.

TL;DR: Because ADAS cells can be expanded in culture without obvious senescence for more than 20 population doublings, they may be a potential source of endothelial cells for cellular pro-angiogenic therapies.

TL;DR: It is shown that bile acids promote glucagon-like peptide-1 (GLP-1) secretion through TGR5 in a murine enteroendocrine cell line STC-1, and an adenylate cyclase inhibitor, MDL12330A, significantly suppressed bile acid-promoted GLP- 1 secretion.

TL;DR: Reduction of abdominal white adipose tissue (WAT) weights in rats and mice by feeding lipids from edible seaweed, Undaria pinnatifida is shown and indicates that fucoxanthin upregulates the expression of UCP1 in WAT, which may contribute to reducing WAT weight.

TL;DR: The nature of the phosphatases that mediate the hydrolysis of phosphotyrosine 138 and 213, and phosphoserine and phosphothreonine residues has not been determined and only phosphorylation by CDK1/cdc2 has been demonstrated to increase Src kinase activity.

TL;DR: Adding recombinant human resistin protein to macrophages resulted in enhanced secretion of pro-inflammatory cytokines, TNF-alpha and IL-12, similar to that obtained using 5 microg/ml lipopolysaccharide suggesting that the inflammatory action of resistin is independent of its conformation.

TL;DR: HADSC, that were induced to differentiate into hepatocyte-like cells by the treatment of HGF and OSM, had morphology similar to hepatocytes and they expressed albumin in vivo, and may become an alternative source to hepatocyte regeneration or liver cell transplantation.

TL;DR: It is suggested that AMPK is a novel and critical component of both inhibition of adipocyte differentiation and apoptosis of mature adipocytes by genistein or EGCG or capsaicin further implying AMPK as a prime target of obesity control.

TL;DR: Several proapoptotic Bcl-2 family proteins, such as PUMA and Noxa, are shown to be critical mediators of p53-dependent apoptosis.

TL;DR: It is suggested that resveratrol augments cellular antioxidant defense capacity through induction of HO-1 via Nrf2-ARE signaling, thereby protecting PC12 cells from oxidative stress.

TL;DR: It is shown that MG concentration varies in the range of 30-75 microM in various plant species and it increases 2- to 6-fold in response to salinity, drought, and cold stress conditions.

TL;DR: The findings suggest that GPR119, which is a novel endogenous receptor for LPC, is involved in insulin secretion from beta-cells, and is a potential target for anti-diabetic drug development.

TL;DR: A review of BMP signaling pathways in the context of craniofacial, axial, and limb development will focus on recent advances of the role of different ligands, receptors, Smads, and BMP regulators in osteoblast and chondrocyte differentiation during embryonic development.

TL;DR: Preclinical data suggest that agents that inhibit p53 may be effective therapeutics for several neurodegenerative conditions.

TL;DR: This review is a brief summary of the current knowledge about some of the crucial factors involved in growth plate development.

TL;DR: Large amounts of HO proteins from human and rat can now be prepared in truncated soluble form, and the crystal structures of some HO proteins have been determined, which have greatly facilitated the understanding of the mechanisms of individual steps of the HO reaction.

TL;DR: The inward rectifier K(+) channel Kir2.1 mediates the potassium I(K1) current in the heart and a valine-to-isoleucine mutation at position 93 (V93I) of Kir1.1 was found in all affected members in one kindred.

TL;DR: In vitro studies showed that adiponectin inhibited M-CSF- and RANKL-induced differentiation of mouse bone marrow macrophages and human CD14-positive mononuclear cells into osteoclast and also suppressed the bone-resorption activity of osteoclasts, suggesting that adip onectin manipulation could be therapeutically beneficial for patients with osteopenia.

TL;DR: These pleiotropic actions of sex steroids on virtually all aspects of bone metabolism belie the importance of the skeleton not only in providing structural support for the body and in locomotion, but also as a dynamic tissue responsive to the reproductive needs of the organism for calcium.

TL;DR: It is concluded that ER-alpha36 is a unique variant of ER- alpha66 that is predicted to function as a dominant-negative effector of hER-alpha66-mediated estrogen-responsive gene pathways and has the potential to trigger membrane-initiated mitogenic estrogen signaling.

TL;DR: Curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose dependent manner with an IC(50) of approximately 5 microM and may represent a novel treatment for malarial infection.

TL;DR: Results suggest for the first time that the CREB-PPARgamma signaling pathway may be involved in the high fat diet-induced liver steatosis.

TL;DR: H(2)S significantly inhibited HOCl-mediated inactivation of alpha(1)-antiproteinase and protein oxidation to a comparable extent to reduced glutathione and inhibitedHOCl-induced cytotoxicity, intracellular protein oxidation, and lipid peroxidation in SH-SY5Y cells.

TL;DR: It is suggested that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-Catenin-Tcf transcriptional activity is due to the decreased nuclear beta- catenin and Tcf-4 proteins.

TL;DR: Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, and human and mouse embryonic stem cells express Kit transcripts.

TL;DR: In this article, the role of non-haem Fe(II)-dependent oxygenases in the regulation of hypoxia inducible factor (HIF) transcriptional system has been investigated.

TL;DR: Rieske non-heme iron oxygenases catalyze stereo- and regiospecific reactions and the orientation of binding of the substrate to the enzyme is hypothesized to control the substrate selectivity and regio-specificity of product formation.

TL;DR: Bone microenvironments possess unique biological features that enable circulating cancer cells to home, survive and proliferate, and destroy bone as discussed by the authors, and cancers that develop bone metastases likely have the capacity to utilize these unique bone environments for colonization and bone destruction.