Showing papers in "Biochemical and Biophysical Research Communications in 2007"

TL;DR: The addition of a positive charge to NPs may improve their potential as nanoparticulate carriers for drug delivery and enhance their ability to internalize into mammalian cells.

TL;DR: It is demonstrated that oxygen concentrations affected many aspects of stem-cell physiology, including growth and in vitro development, and may be a critical parameter during expansion and differentiation.

TL;DR: In this paper, the authors used an oligonucleotide microarray to monitor rice (Oryza sativa) microRNA expression profile under drought stress and identified two drought-induced microRNAs.

TL;DR: In this article, the authors investigated UPR activation in the substantia nigra of control and PD patients and found that the UPR is activated in PD and associated with the accumulation and aggregation of alpha-synuclein.

TL;DR: A 2-layer predictor, called MemType-2L, has been developed and is featured by incorporating the evolution information through representing the protein samples with the Pse-PSSM vectors, and by containing an ensemble classifier formed by fusing many powerful individual OET-KNN (Optimized Evidence-Theoretic K-Nearest Neighbor) classifiers.

TL;DR: Results strongly suggest that GPR55 is a specific and functional receptor for lysophosphatidylinositol, which induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably GPR 55-expressing cells.

TL;DR: The favorable effects of hMSCs appear to reflect the impact of secreted factors rather than engraftment, differentiation, or cell fusion.

TL;DR: Inhalation of hydrogen gas is proposed as a widely applicable method to reduce oxidative stress and reduced levels of serum alanine aminotransferase and hepatic malondialdehyde, and helium gas showed no protective effect, suggesting that the protective effect by hydrogenGas is specific.

TL;DR: Sunitinib is approved for the treatment of those tumors that are resistant to imatinib (STI-571, Gleevec), another Kit and PDGFRalpha protein-tyrosine kinase inhibitor.

TL;DR: The results from this study indicate that this novel soybean GmDREB2 gene functions as an important transcriptional activator and may be useful in improving of plant tolerance to abiotic stresses in plants.

TL;DR: The results may be interpreted in terms of a glypican-caveolae-eNOS mechanism for shear-induced NO transduction, with PGI(2) being transduced in basal adhesion plaques that sense the same reaction stress whether the glycocalyx is intact or not.

TL;DR: It is shown that the hepatic gene expression of FGF21 is regulated by the peroxisome proliferator-activated receptor alpha (PPARalpha), and the potential importance of PPARalpha for FGF 21 expression also in human liver was shown by Wy-14,643 induction of F GF21 mRNA in human primary hepatocytes.

TL;DR: Recombinant chemerin induced the phosphorylation of extracellular signal-regulated kinases 1/2 and lipolysis in differentiated 3T3-L1 adipocytes and likely regulates adipocyte function by autocrine/paracrine mechanisms.

TL;DR: This work shows approximately 3-7 fold dose- and time-dependent increase in mitochondrial superoxide production in rat cardiac derived H9c2 myocytes and/or in human coronary artery endothelial cells triggered by Antimycin A, Paraquat, Doxorubicin or high glucose.

TL;DR: The isolation and the identification of another constituent implicated in the anti-diabetic effect of olive leaves are described, i.e. oleanolic acid, and it is shown that this triterpene is an agonist for TGR5, a member of G-protein coupled receptor activated by bile acids and which mediates some of their various cellular and physiological effect.

TL;DR: It is found that an Arabidopsis mutant plant (acl5/spms), which cannot produce spermine, is hypersensitive to high salt, and examination of drought sensitivity of the mutant and comparison with wild type plants indicated hypersensitivity to drought.

TL;DR: It is demonstrated that ASCs have a marked impact on anti-apoptosis and angiogenesis and helps to explain data of stem cells benefit without transdifferentiation.

TL;DR: This study demonstrates that the CXCR4/CXCL12 signaling axis can induce angiogenesis and progression of tumors by increasing expression of VEGF through the activation of PI3K/Akt pathway.

TL;DR: It is found that arsenic causes the depletion of S-adenosylmethionine, the main cellular methyl donor, and represses the expression of the DNA methyltransferase genes DNMT1 and DNMT3A, and possibly as a consequence of these two complementary mechanisms, long-term exposure to arsenic results in DNA hypomethylation.

TL;DR: This study provides the largest genomewide survey of mature miRNA transcripts in head and neck cancer cell lines and validated several miRNAs included tumor suppressor genes, kinesin family member 1B isoform alpha, and hypermethylated in cancer 2 (HIC2), and pleomorphic adenoma gene 1 (PLAG1).

TL;DR: An automated method for predicting signal peptide sequences and their cleavage sites in eukaryotic and bacterial protein sequences is developed, called Signal-CF, which is featured by high success prediction rates with short computational time, and hence is particularly useful for the analysis of large-scale datasets.

TL;DR: It is shown that LRRK2 immunoprecipitated from cells has a detectable GTPase activity that is disrupted by a familial mutation associated with PD located within the G TPase domain, R1441C.

TL;DR: It is demonstrated that MSCs can modulate the function of activated SCs via paracrine mechanisms provide a plausible explanation for the protective role of M SCs in liver inflammation and fibrosis, which may also be relevant to other models of tissue fibrosis.

TL;DR: This study shows the first evidence that with an acute low-intensity exercise that is minimally stressful, hippocampal activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield to greater benefits in hippocampal functions compared to the more strenuous forms.

TL;DR: Enhanced expression of CXCL12 in both the lungs and plasma of patients with lung fibrosis found and most of the circulating fibrocytes in patients with interstitial lung diseases were negative for the myofibroblast marker alpha-smooth muscle actin, suggesting a relatively undifferentiated phenotype.

TL;DR: GPR120 regulates adipogenic processes such as adipocyte development and differentiation, and use of a small interference RNA (siRNA) to down-regulate GPR120 expression resulted in inhibition of adipocyte differentiation.

TL;DR: This paper has developed a novel method for predicting signal peptide sequences and their cleavage sites in human, plant, animal, eukaryotic, Gram-positive, and Gram-negative protein sequences, respectively called Signal-3L, featured by high success prediction rates with short computational time, and hence is particularly useful for the analysis of large-scale datasets.

TL;DR: A top-down predictor, called EzyPred, is developed by fusing the results derived from the functional domain and evolution information, by which one can get the desired 3-level results for a query protein sequence within less than 90 s.

TL;DR: It is concluded that CD133+ HSC are a not yet recognized progenitor cell compartment with characteristics of early EPC, and their potential to differentiate into endothelial or hepatocyte lineages suggests important functions of CD133- HSC during liver regeneration.

TL;DR: Results suggest that aptamer NK2 has inhibitory effects on M. tuberculosis and can be used as antimycobacterial agent.