Showing papers in "Biochemical and Biophysical Research Communications in 2008"

TL;DR: Atomic force microscopy indentation using a micro-sized spherical probe was carried out to characterize the elasticity of benign and cancerous human breast epithelial cells, showing a significant difference in the organization of their sub-membrane actin structures which directly contribute to their difference in cell elasticity.

TL;DR: Data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercETin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.

TL;DR: Inhalation of H(2) gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery, thereby preventing deleterious left ventricular remodeling.

TL;DR: The biochemical relationship between PINK1, Parkin, and the mitochondria is demonstrated and the possible mechanism of PINK-Parkin-associated PD pathogenesis is suggested.

TL;DR: TGR5-immunoreactivity in Kupffer cells was increased in rat livers following bile-duct ligation, suggesting that TGR5 may play a protective role in obstructive cholestasis preventing excessive cytokine production thereby reducing liver injury.

TL;DR: It is demonstrated that Twist can transcriptionally repress E-cadherin in breast cancer cells using transient promoter assays and that this regulation was verified by quantitative real-time PCR and immunohistochemistry on a cohort of cancer samples.

TL;DR: Ectopic miR-34a expression resulted in cell cycle arrest and growth inhibition and attenuated chemoresistance to anticancer drug camptothecin by inducing apoptosis, suggesting a potential role of miR -34a for the treatment of p53-defective prostate cancer.

TL;DR: The role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation is described and it is strongly suggested that miR -125b is involved in osteoblast differentiation through the regulation of cell proliferation.

TL;DR: It is shown that all the major brain cell types (neurons, astrocytes, and microglia) are capable of clearing the extracellular alpha-synuclein aggregates by internalization and degradation and that clearance may be regulated by the activation state of these cells.

TL;DR: A method for site-specifically incorporating l-lysine derivatives into proteins in mammalian cells, based on the expression of the pyrrolysyl-tRNA synthetase (PylRS)-tRNA(Pyl) pair from Methanosarcina mazei is reported.

TL;DR: Over-expression of miR126 in a lung cancer cell line resulted in a decrease in Crk protein without any alteration in the associated mRNA, suggesting that the effects on invasion may be partially mediated through Crk regulation.

TL;DR: The number genes of total AP2/ERF family genes, DREB subfamily, and ERF subfamily from Populus trichocarpa were about 1.4-1.6-fold more than those from A. thaliana, and the rates were very similar for the putative homologs between Populus and Arabidopsis.

TL;DR: It is shown that TRAM recruits TRIF to the plasma membrane and the internalized signaling complex consisting of TLR4 and TRAM colocalizes with TRAF3, a signaling molecule downstream of TRIF, in endosome/lysosome after relocation from the cell surface.

TL;DR: The data indicate that AhR-activation is an important signaling pathway for IDO expression and suggest a critical role of IDO in the mechanism leading to the generation of T(reg) that mediates the immune suppression through activation of AhR.

TL;DR: The results indicate that Th17 cells may contribute to gastric cancer pathogenesis and the mRNA expression levels of Th17-related factors in tumor tissues and the serum concentrations of IL-17 and IL-23 cytokines were significantly increased in patients with advanced Gastric cancer.

TL;DR: Bcl-w, an anti-apoptotic Bcl-2 family member, is a direct target of miR-122 that functions as an endogenous apoptosis regulator in these HCC-derived cell lines.

TL;DR: Keap1 expression was investigated using RT-PCR and found that it was downregulated in lung cancer cell lines and tissues when compared with a normal bronchial epithelial cell line, indicating the silencing mechanism to be promoter methylation.

TL;DR: Transfection of SMAD in GBM cells inhibited their growth, suggesting that SMAD may drive GBM stem cells to differentiate to CD133- cells through up-regulation of miR-451 and reduces their tumorigenicity.

TL;DR: The present results show that IL-17A plays a pivotal role in the pathogenesis of DSS-induced colitis, while MCP-1 and G-CSF may be crucially involved in the IL- 17A-induced inflammation.

TL;DR: A simple method for high-throughput screening of miRNAs was developed and it was found that mir-126, a cell growth suppressor, targets IRS-1.

TL;DR: These findings provide the first evidence for the up-regulated expression of miR-143 in the mesenteric fat of high-fat diet-induced obese mice, which might contribute to the regulated expression of adipocyte genes involved in the pathophysiology of obesity.

TL;DR: The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, V EGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropil in-2).

TL;DR: Pharmacological and genetic approaches are employed to show that GPR81, an orphan G-protein-coupled receptor with relatively restricted expression in the adipose tissues, functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate.

TL;DR: Investigation of the genome-wide effect of maternal exposure to BPA on the epigenome in mouse forebrain at E12.5 and at E14.5 finds epigenetic alterations in promoter-associated CGIs after exposureto BPA may underlie some effects on brain development.

TL;DR: It is reported that lipid rafts in Vero E6 cells are involved in the entry of severe acute respiratory syndrome coronavirus (SARS-CoV).

TL;DR: The results from this study demonstrate that the dental cell sources exhibit comparable surface marker and bone-associated marker profiles parallel to those of other mesenchymal stem cell sources, yet distinct from the buccal mucosa fibroblasts.

TL;DR: Results show that rhLM-111, -332, and -511 are good substrates to expand undifferentiated hESCs due to their high affinity to integrin alpha6beta1 expressed on hESC.

TL;DR: Ex vivo Sirt1 constitutes a determinant of renal tubular cell apoptosis by regulating cellular ROS levels and by preventing the depletion of ROS required for cell survival by regulating catalase expression.

TL;DR: It is proposed that RSV elevates glucose uptake in muscle cells through a mechanism that involves sirtuins and AMPK and possibly stimulation of GLUT4 transporter intrinsic activity.