Showing papers in "Biochemical and Biophysical Research Communications in 2010"

TL;DR: The data suggest that GNPs are able to cross the blood-brain barrier and accumulate in the neural tissue, and the accumulation of the particles does not produce sub-acute physiological damage.

TL;DR: Increased circulating miR-1 level was significantly higher in plasma from AMI patients compared with non-AMI subjects and the level was dropped to normal on discharge following medication, revealing that circulating miD-1 may be a novel, independent biomarker for diagnosis of AMI.

TL;DR: The evolution of mammalian Trx system compared to its prokaryotic counterparts may be an adaptation to the use of hydrogen peroxide and nitric oxide in redox regulation and signal transduction.

TL;DR: It is revealed that miR-27a is involved in adipocyte differentiation by binding to the PPARgamma 3'-UTR whose sequence motifs are highly conserved in mammals and which might be associated with adipose tissue dysregulation in obesity.

TL;DR: This is the first report for the detection of intracellular ROS in a cyanobacterium by fluorescence microscopy using DCFH-DA and thereby suggesting the applicability of this method in the study of in vivo generation of ROS.

TL;DR: A sandwich ELISA system enabling detection of circulating serum salphaKl levels and relationship to indices of renal function, mineral metabolism, age and sex in healthy subjects was established and correlated negatively with age and Ca, and positively with Pi.

TL;DR: It is demonstrated that shear stress forces regulate the expression of miRNAs in ECs, and that miR-21 influences endothelial biology by decreasing apoptosis and activating the NO(*) pathway.

TL;DR: One approach for this purpose is administration of epoxidated all-trans polyisoprenoids, which enhance both CoQ biosynthesis and levels in experimental systems.

TL;DR: This article re-examines and challenges some basic assumptions in the nutritional antioxidant field and suggests that pro-oxidants can be better for you in some circumstances.

TL;DR: C-RAF plays a key role in this paradoxical increase in downstream MEK-ERK activation and is effective in blocking MEK1/2 and ERK 1/2 activation in cells containing the oncogenic B-RAf Val600Glu activating mutation.

TL;DR: SerummiR-146a and miR-223 might serve as new biomarkers for sepsis with high specificity and sensitivity, and were significantly reduced in septic patients compared with SIRS patients and healthy controls.

TL;DR: The novel presence of ChemR23 in human ECs and its significant up-regulation by pro-inflammatory cytokines, TNF-alpha, IL-1beta and IL-6 are demonstrated and data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity.

TL;DR: It is demonstrated that CuO NPs possess a genotoxic potential in A549 cells which may be mediated through oxidative stress and will need to be further investigated to determine whether long-term exposure consequences may exist for CuONPs application.

TL;DR: The data suggest that miR-34a contributes to endothelial senescence through suppression of SIRT1.

TL;DR: It is revealed that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCS can be generated in short duration for cell therapy in regenerative medicine and tissue engineering.

TL;DR: It seems that the quinone methide structure present in celastrol can react with the thiol groups of cysteine residues, forming covalent protein adducts.

TL;DR: The findings suggest that bovine breast milk contains RNAs capable for being transferred to living cells and involved in the development of calf's gastrointestinal and immune systems.

TL;DR: A method of using RNA transfection as a tool for reprogramming human fibroblasts to iPS completely avoids DNA integration and may be developed to replace the use of DNA vectors in the formation of iPS.

TL;DR: Targeting myostatin-family ligands using ACVR2B-Fc or related molecules is an important and potent therapeutic avenue in cancer cachexia and Enhanced cachexia in mystatin knockouts indicates that host-derivedMyostatin is not the sole mediator of muscle wasting in cancer.

TL;DR: Improved understanding of the p53 pathway should lead to better diagnosis and treatment of cancer in the future, and the small molecule PRIMA-1 restores wild type conformation and DNA binding to mutants p53, induces mutant p53-dependent apoptosis, and inhibits tumor growth in vivo.

TL;DR: The current knowledge about the molecular mechanisms regulating the processing and release of AIF from the mitochondria will be summarized and discussed in this review.

TL;DR: Results indicate that toxins CspD, Hha, and HokA influence persister cell formation via MqsR and that Hfq plays an important role in the regulation of persistercell formation via regulation of transport or outer membrane proteins OppA and YbfM.

TL;DR: It is demonstrated that Hrs, an ESCRT-0 protein, is required for fascilitating the secretion of exosomes in dendritic cells (DCs) and is involved in the regulation of antigen-presentation activity through the exosome secretion.

TL;DR: Wang et al. as mentioned in this paper found ectopic expression of miR-375 could diminish the transcriptional activity of yes-associated protein (YAP) and immunoblotting revealed miRNA suppressed endogenous YAP protein level, implicating a potential therapeutic role in HCC treatment.

TL;DR: This study provides strong evidence that canonical Wnt signaling plays an important role in lung cancer stem cell properties, and it also regulates OCT-4, a lung cancerstem cell marker.

TL;DR: It is demonstrated for the first time that omentin has a vasodilating effect on isolated blood vessels, which is mediated through endothelium-derived NO.

TL;DR: Findings provide evidence for a crucial role of PI3K/Akt-HIF-1α-CX CR4/CXCR7 pathway on enhanced migration, adhesion and survival of HP-MSCs in vitro.

TL;DR: It is demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastriccancer.

TL;DR: The present study is the first to show that microRNA signatures can possibly be utilized to identify patients exhibiting atherosclerotic CAD in general and those at risk for acute coronary syndromes.

TL;DR: It is found that miR-195 was downregulated in cancer tissues and was further suggested to exert its proapoptotic function mainly through targeting Bcl-2 expression.