Showing papers in "Biochemical and Biophysical Research Communications in 2011"

TL;DR: Helical intermediates have been predicted to be crucial on-pathway intermediates in amyloid fibrillogenesis, and the structure presented here presents a new target for investigation of early events in Aβ(1-40) fibrillsogenesis.

TL;DR: IL-17 is suggested to be a novel indicator of prognosis in the patients with colorectal carcinoma and could serve as a novel therapeutic target for coloreCTal carcinomas, and the results indicate that IL-17 producing cells may facilitate development of colorective carcinoma by fostering angiogenesis via promote VEGF production from cancer cells.

TL;DR: A novel experimental in vivo platform for replacing mouse liver with functioning human liver tissue that had zonal position-specific enzyme expression and a global gene expression pattern representative of mature human liver and could generate a human-specific profile of drug metabolism is developed.

TL;DR: It is demonstrated for the first time that omentin plays an anti-inflammatory role by preventing the TNF-α-induced COX-2 expression in vascular endothelial cells.

TL;DR: A better understanding of the intricate relationships between mitochondrial ROS and autophagy may ultimately allow cancer biologists to harness mitochondrial ROS-mediated autophagic pathways for cancer drug discovery.

TL;DR: Analysis of changes induced by a brief salt stress showed that NaCl modified the nitrosylation level of a small proportion of endogenously nitroSylated proteins and did not concern all nitrosothiols in these proteins.

TL;DR: Evidence is provided that H(2)S, as a gasotransmitter, improves drought resistance in Arabidopsis and helps seedlings after treatment with NaHS show a higher survival rate and a significant reduction in the size of the stomatal aperture.

TL;DR: Serum miR-221, upregulated in HCC, can provide predictive significance for prognosis of HCC patients and is found to be differentially overexpressed in H CC serum samples.

TL;DR: Research highlights ► Nrf2 anti-oxidant function is impaired when HDAC activity is inhibited, and HDAC inhibition decreases NRF2 protein stability and both correlate in COPD samples.

TL;DR: The data suggest that there are close links between reduced AMPK activity and inflammation in white adipose tissue, and whole-body insulin resistance in obese humans.

TL;DR: Ex vivo miR-101 regulates expression of APP in human cells via a specific site located within its 3'-UTR, and it is demonstrated that, across a series of human cell lines, highest expression of miR -101 levels was observed in model NT2 neurons.

TL;DR: It is reported that over-expression of miR-132 andMiR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over- expression of these miRNAs is likely due to increased expression of several E2F target genes.

TL;DR: Experimental evidence is provided supporting that GSCs derived from GBM surgical specimens or xenografts display greater invasive potential in vitro and in vivo than matched non-stem tumor cells, and several invasion-associated proteins that were differentially expressed in G SCs relative to non- stem tumor cells are identified.

TL;DR: These results are the first to link elevated oxidative stress and mitochondrial membrane depolarization to salinomycin-mediated apoptosis of prostate cancer cells.

TL;DR: It is found that miR-181a was frequently downregulated in OSCC and may function as an OSCC suppressor by targeting on K-ras oncogene, which should be considered for therapeutic application for OSCC.

TL;DR: It is demonstrated that primary necrotic cells unexpectedly show Annexin V-positive/PI-negative staining before they become PI-positive, and that primary Necrotic and apoptotic AnnexinV- positive/ PI-negative cells can be discriminated by necrostatin-1, an inhibitor of primary necrosis by inhibition of RIP1.

TL;DR: Two reference genes, beta tubulin and ubiquitin-conjugating protein (UBI-3) showed high stability in sample pools with abiotic stress and hormonal treatments, and were selected for qRT-PCR analysis under the experimental conditions tested in pepper.

TL;DR: Results suggested that miR-29b is involved in the activation of HSCs and could be a candidate molecule for suppressing their activation and consequent liver fibrosis.

TL;DR: It is postulated that the mammalian klotho gene is up-regulated by liganded VDR via multiple remote VDREs, including the identification of vitamin D responsive elements (VDREs) in the vicinity of both the mouse and human klOTHo genes.

TL;DR: Stbd1 may function as a novel cargo binding protein that delivers glycogen to lysosomes in an autophagic pathway that could be termed "glycophagy", according to the consensus of other AIM sequences in cargo-specifying proteins such as p62 and Nix.

TL;DR: It is demonstrated that α-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface.

TL;DR: It is demonstrated that miR-125b is frequently down-regulated in osteosarcoma samples and human osteosARcoma cell lines, and it is discovered that the expression ofMiR- 125b is regulated by STAT3 at the level of transcription, which points to an important role in the molecular etiology of osteoscarcoma.

TL;DR: It is shown that T2Rs are expressed in multiple regions of the rat brain and functional assays showed an increase in intracellular calcium levels after the application of exogenous ligands for T2R4, denatonium benzoate and quinine to these cultured cells, suggesting that endogenous T1R4 expressed in these cells is functional.

TL;DR: The presence of CRAC motifs in GPCRs indicates that interaction of cholesterol with GPCrons could be specific in nature and provides novel insight in the molecular nature of GPCR-cholesterol interaction.

TL;DR: EGCG, a major component of green tea, is an ATP-competitive inhibitor of both phosphoinositide-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with K(i) values of 380 and 320nM respectively.

TL;DR: A novel mechanism for EGCG-induced melanoma inhibition is provided: inflammasome downregulation→ decreased IL-1β secretion→decreased NF-κB activities→ decreased cell growth, which suggests inflammaomes and IL- 1β could be potential targets for future melanoma therapeutics.

TL;DR: Evidence is provided that angiogenic miRNAs might play an important role in the control of EPC function, and that their dysregulation might contribute to EPC dysfunction in patients suffering from coronary artery disease, and the development of novel therapeutic modalities for the prevention and treatment of CAD.

TL;DR: The studies show that B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes, thereby proving its potential as a possible anti-Parkinsonian agent.

TL;DR: This review presents an emerging concept of Nrf2 in diabetic neuropathy, a transcription factor modulating oxidative stress that may provide an enthralling avenue to optimize neuroprotection in diabetes and diabetic neuropathic pain.

TL;DR: It is concluded that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting TNFAIP3.