Showing papers in "Biochemical and Biophysical Research Communications in 2013"

TL;DR: The results suggest, for the first time, the CPC-exosomes can be used as a therapeutic vehicle for cardioprotection, and highlights a new perspective for using non-cell exosomes for cardiac disease.

TL;DR: This review elaborates on the response networks of heat stress in plants, including the Hsf and Hsp response pathways, the response of ROS and the network of the hormones, and the production ofheat stress response elements during particular physiological periods of the plant.

TL;DR: Examination of the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR indicates it enhanced the aggressive behavior of NSCLC cells.

TL;DR: Additional interactions with the S1', S2' or S2 extensive subsite may increase DPP-4 inhibition beyond the level afforded by the fundamental interactions withThe S1 and S2 subsites and are more effective than forming a covalent bond with Ser630.

TL;DR: Three aspects of cancer were chosen to be modeled based on their ability to resist anti-cancer drugs: 3D, multicellularity, and extracellular matrix (ECM) barrier, and it is demonstrated that the 3D heterospheroid model is more resistant to drug over 2D monolayer and homospheoid cultures.

TL;DR: It is found that the ANCR expression level is significantly decreased during hFOB1.19 cell differentiation and that ANCR is associated with enhancer of zeste homolog 2 (EZH2) and that this association results in the inhibition of both Runx2 expression and subsequent osteoblast differentiation.

TL;DR: It is shown that enChIP using the CRISPR system efficiently isolates specific genomic regions and would be a convenient and useful tool for dissecting chromatin structure of genomic regions of interest.

TL;DR: The results reveal a novel post-translational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation, which is important for the growth of lung tumor cells.

TL;DR: The antibacterial mechanism of ε-PL against E. coli O157:H7 may be attributed to disturbance on membrane integrity, oxidative stress by ROS, and effects on various gene expressions, such as regulation of oxidative stress, SOS response, and changes in virulence.

TL;DR: A direct role is presented for ACLY in macrophage inflammatory metabolism and ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators.

TL;DR: A positive link between vitamin D and GSH levels is demonstrated, and it is demonstrated that some beneficial effects of vitamin D supplementation may be mediated by an improvement in the cellular GSH Levels and a decrease in ROS and pro-inflammatory cytokines.

TL;DR: Data indicates that TNFα increased aggrecan degradation products and suggests increased β-galactosidase staining at 21 days without any recovery, suggesting that successful treatments must promote anabolism and cell proliferation in addition to limiting inflammation.

TL;DR: Clinical applications of MSCs are recommended to inhibit TF activity using anti-coagulant agents or genetic approaches to maximize clinical benefit to the patients.

TL;DR: Results indicate that LGG treatment improves insulin sensitivity and reduces lipid accumulation by stimulating adiponectin secretion and consequent activation of AMPK.

TL;DR: A role for RSV in cognition and a microRNA-CREB-BDNF mechanism by which RSV regulates these processes are demonstrated, demonstrating its value as a potential therapeutic target against CNS disorders in aging.

TL;DR: Findings demonstrated that miR-19a/b promote MDR in gastric cancer cells by targeting PTEN, an inhibitor of AKT phosphorylation, is the functional target of miR.

TL;DR: It is shown that CAFs in human breast and ovarian tumors express high levels of the pro- inflammatory factors IL-6, COX-2 and CXCL1, previously identified to be part of a CAF pro-inflammatory gene signature, and that NF-κB is up-regulated in breast and ovary CAFs.

TL;DR: The current knowledge of lncRNAs discoveries in plant is summarized, including their identification, functions and regulation pathways as well as production and mediators, with an emphasizing on the novel regulation mechanisms in plant development.

TL;DR: Immunohistochemistry, Western Blot, qRT-PCR, and ultrastructural analyses demonstrated that the overexpression of miR-21 in UC mucosa and Caco-2 cells impaired the integrity of the tight junctions, resulted in a decrease of the transepithelial electrical resistance and an increase of the inulin permeability.

TL;DR: It is demonstrated, for the first time, that miR-9 can modulate the expression of IFN-induced genes and MHC class I molecules in human cancer cells, suggesting a novel role of miR -9 in linking inflammation and cancer, which remains to be fully characterized.

TL;DR: It is shown that Lipasin is a novel but atypical member of theANGPTL family because it is within the same branch as ANGPTL3 and 4 by phylogenetic analysis and the mRNA levels of Lipasin are dramatically increased in the cold environment whereas those of Angiopoietin-like protein family members are suppressed.

TL;DR: Sl Slug and Snail are sufficient for the induction of single-cell invasion in an in vitro invasion assay and in an embryonic zebrafish xenograft model.

TL;DR: Lipasin, a novel but atypical ANGPTL family member, is emerging as a critical lipid regulator and a potential drug target.

TL;DR: It is suggested that TQ has neuroprotection potential against Aβ1-42 in rat hippocampal and cortical neurons and thus may be a promising candidate for Alzheimer disease treatment.

TL;DR: This study demonstrated that PMSCs improved the wound healing rate in diabetic rats, and placenta-derived mesenchymal stem cells are implicated as a potential angiogenesis cell therapy for repair-resistant chronic wounds in diabetic patients.

TL;DR: It is found that miR-187 was down-regulated in both tumor tissue and plasma of ccRCC patients and plays a tumor suppressor role inccRCC.

TL;DR: The results showed that the major components in Wnt-β-catenin pathway were consistently upregulated in human osteosarcoma cell line Saos2 cells compared to human fetal osteoblasts, whereas the changes in the expression levels of Notch and Hh signaling molecules were not consistent.

TL;DR: Findings indicate that miR-340 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression and metastasis of osteosarcoma through a mechanism involving ROCK1, suggesting mi R-340 as a potential new diagnostic and therapeutic target for the treatment of OS.

TL;DR: The results suggest that SIRT3 protects cardiomyocytes exposed to oxidative stress from apoptosis via a mechanism that may involve the NF-κB pathway.

TL;DR: It is suggested that a multiple-MSC infusion strategy offers a viable clinical option for T2D patients and the restoration of islet structure and number after multiple MSC treatments is suggested.