Showing papers in "Biochemical and Biophysical Research Communications in 2016"

TL;DR: This study demonstrates that whole genome shotgun sequencing has multiple advantages compared with the 16S amplicon method including enhanced detection of bacterial species, increased detection of diversity and increased prediction of genes.

TL;DR: It is shown that acyl-CoA synthetase long-chain family member 4 (ACSL4) is required for ferroptotic cancer cell death and Mechanically, ACSL4-mediated production of 5-hydroxyeicosatetraenoic acid (5-HETE) contributed to ferroPTosis.

TL;DR: It is shown that CDGSH iron sulfur domain 1 (CISD1), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death and stabilization of the iron sulfur cluster of CISD1 by pioglitazone inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroPTosis.

TL;DR: The results firstly reveal that TMAO induces inflammation and endothelial dysfunction via activating ROS-TXNIP-NLRP3 inflammasome, and suggest a likely mechanism for T MAO-dependent enhancement in atherosclerosis and cardiovascular risks.

TL;DR: It is found that X inactivate-specific transcript is over-expressed in NSCLC, and its increased level is associated with shorter survival and poorer prognosis, and oncogenic functions were partly depending on silencing KLF2 expression.

TL;DR: The results suggest that MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively.

TL;DR: It is shown that MEG3 expression level is significantly down-regulated in the retinas of STZ-induced diabetic mice, and endothelial cells upon high glucose and oxidative stress, and up-regulation may serve as a therapeutic strategy for treating diabetes-related microvascular complications.

TL;DR: It is found that baicalein is a potent inhibitor of erastin-induced ferroptosis in pancreatic cancer cells and could be a potential therapeutic agent for ferroptic tissue injury.

TL;DR: HOTAIR upregulation in cardiomyocytes of LPS-induced sepsis mice promoted TNF-α production in the circulation by activating NF-κB, involving the phosphorylation of NF-σB p65 subunit.

TL;DR: It is revealed that there is a HIF-2α-MALAT1-miR-216b axis regulating MDR of HCC cells via modulating autophagy and this study investigated the regulative effect of MALAT1 on multi-drug resistance (MDR), and the underlying mechanism.

TL;DR: Investigation of circRNA expression differences in HT22 cells with oxygen-glucose deprivation/reoxygenation versus normal controls suggests that the overlapping expression of mmu-circRNA-015947 might be involved in the process of cerebral IRI and presents a novel molecular target for clinical therapy.

TL;DR: This study developed a novel exosome surface display technology by exploiting mammalian cell secreted nano-vesicles and their trans-membrane protein tetraspanins and established the stable engineered cells to harness the ability of this robust system for continuous production, secretion, and uptake of displayed exosomes with minimal impact on human cell biology.

TL;DR: Intriguingly, several circRNAs were predicted to involved in chilling responsive process, such as redox reaction, cell wall degradation, Arginine and polyamine metabolism, heat and cold shock protein, energy metabolism, Jasmonic acid and abscisic acid metabolism, low temperature and salt responsive protein and low temperature-induced transcription factors(CBF and WRKY).

TL;DR: Findings indicate that Fanconi anemia complementation group D2 (FANCD2), a nuclear protein involved in DNA damage repair, protects against ferroptosis-mediated injury in bone marrow stromal cells (BMSCs) and could represent an amenable target for the development of novel anticancer therapies aiming to reduce the side effects of ferroPTosis inducers.

TL;DR: A novel aspect of the UPR is demonstrated by electron microscopy and immunostaining analyses, whereby multivesicular body (MVB) formation was enhanced after ER stress, whereby IRE1 and PERK-mediated pathways are involved in ER stress-dependent exosome release.

TL;DR: Findings reveal both mitochondrial, genotoxic, and inflammatory stresses are features of direct cell exposure to E-cig aerosols which are ensued by inflammatory duress, raising a concern on deleterious effect of vaping.

TL;DR: PVT1, a long non-coding RNA encoded by the human PVT1 gene, is located in the well-known cancer-related region 8q24, also known as the8q24 'gene desert.

TL;DR: It is shown that AQP9 facilitates the membrane transport of H2O2 in human and mice cells, and H 2O2-induced cytotoxicity was attenuated by AQP 9 deficiency in humanand mice cells.

TL;DR: This study demonstrates that ELAVL1 expression augmented with a concomitant increase in caspase-1 and IL-1 beta expression in human hearts and human ventricular cardiomyocytes under hyperglycemic condition and highlights the potential therapeutic implications of targeting miR-9/ELAVL 1 in preventing cardiomeocyte cell loss during HF in diabetics.

TL;DR: Upregulation of lncRNA MEG3 enhances hepatic insulin resistance via increasing foxO1expression, suggesting that MEG 3 may be a potential target and therapeutic strategy for diabetes.

TL;DR: HNF1A-AS1-miR-30b axis is identified as a key regulator in hepatocarcinogenesis, which may be promising biomarkers and therapeutic targets in the future.

TL;DR: It is demonstrated that miR-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6.

TL;DR: Results showed that LRG improved hepatocyte steatosis by inducing autophagy, and the AMPK/mTOR pathway is involved, and these findings suggest an important mechanism for the positive effects of LRG on hepatic Steatosis, and provide new evidence for clinical use ofLRG in NAFLD.

TL;DR: The results suggest that ADSC-exo modulates cellular phenotypes of ALS including SOD-1 aggregation and mitochondrial dysfunction, and can be a therapeutic candidate for ALS.

TL;DR: The results suggest that the exosomal protein and miRNA content reflects the physiological condition of its source and that exosomes induce phenotypic changes via autocrine signaling.

TL;DR: Current literature is reviewed to generate a specific hypothesis: that the accumulation of ET in vivo is an adaptive mechanism, involving the regulated uptake and concentration of an exogenous natural compound to minimize oxidative damage.

TL;DR: Western blot and immunofluorescence results indicated that caspase 3 activation was reduced, whereas bcl-2 level was significantly increased by metformin, which attenuated SCI by inhibiting apoptosis and inflammation and enhancing the autophagy via the mTOR/p70S6K signalling pathway.

TL;DR: It is shown that primarily human fibrillar alpha-synuclein increased the production and secretion of pro-inflammatory cytokines by microglial BV2 cells compared to monomeric and oligomeric alpha- synuclein.

TL;DR: MEG3 is downregulated in breast cancer tissues and affects breast cancer cells' malignant behaviors, which indicate MEG3 a potential therapeutic target for breast cancer.

TL;DR: A therapeutic potential of probiotics for ameliorating dyslipidemia and NAFLD is confirmed and shifts in the diversity of dominant gut bacteria were caused by HFD and restored by LGG treatment.