Showing papers in "Biochemical Pharmacology in 1961"

TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.

TL;DR: Amino-oxyacetic acid has been found to be a potent inhibitor of the enzyme γ-aminobutyric acid-α-ketoglutaric acid transaminase derived both from E. coli and mammalian brain.

TL;DR: In general, —SH enzymes were found to be more readily inhibited than enzymes not possessing —SH groups and to be protected by sulphydryl compounds, such as glutathione.

TL;DR: In anaesthetized cats poisoned with lethal doses of 37 S-N + plasma concentrations of about 2 × 10 −5 M (4 μg/ml) were needed to counteract neuromuscular block, bradycardia, hypotension and respiratory failure.

TL;DR: The anabolic action of male sex hormones appears to account for the increased enzyme activities in male rats.

TL;DR: Some novel methods for the micro-estimation and quantitative isolation of polysaccharide sulphates using 6:9-diamino-2-ethoxy-acridine lactate (Rivanol) are described.

TL;DR: The metabolism of twenty-five N:N-dimethyl carbamates and twenty-three related compounds was investigated and isolan metabolism was evident when followed both by the formation of formaldehyde-yielding material and reduction in the ability to inhibit cholinesterase in vitro.

TL;DR: The effect of antimalarial drugs upon the uptake of P 32 -labeled phosphate into ribonucleic acid (RNA) and deoxyribonuclear acid (DNA) of chick blood infected with Plasmodium gallinaceum was studied in vitro as mentioned in this paper.

TL;DR: It is concluded that the majority of the radioactivity excreted in the urine represents compounds formed from alkylation by the drug, rather than metabolites formed by enzymic action.

TL;DR: Two chemically different types of biologically active (radiomimetic) alkylating agents, i.e. nitrogen mustard and dimethyl myleran, are shown to produce very different patterns of response in leukaemia cells grown as isolated cells in tissue culture.

TL;DR: The rates of metabolism of hexobarbital and chlorpromazine, but not those of codeine or p -nitrobenzoic acid are affected, and the effects of sham-operation are significantly less than those of partial hepatectomy.

TL;DR: At the time of sacrifice, after the administration of MO-911 and l-DOPA, the mice were markedly hyperactive, but the relative contribution of the increases in DOPA, dopamine, norepinephrine or serotonin to this activity could not be determined.

TL;DR: These experiments indicate that possibly in the intact animal psilocybin is rapidly dephosphorylated and is pharmacologically active as psilocin, while the duration of the effect might be controlled by the oxidation of the latter compound to an o-quinone type of structure.

TL;DR: High-speed centrifugation of preparations of brain (rat) has permitted the separation of two forms of 5-hydroxytryptamine (5-HT; serotonin), “bound” and “free”, and the influence of drugs on these forms has been studied.

TL;DR: Administration of thyroxin to rats shortens the duration of action of zoxazolamine by accelerating its metabolism, and inhibits the metabolism of hexobarbital by inhibiting its metabolism.

TL;DR: In this article, the major reaction which Myleran undergoes in vivo is reaction with cysteine or a cysteinyl moiety to form a cyclic sulphonium ion which undergoes decomposition to tetrahydrothiophene.

TL;DR: Three lipid-soluble quaternary compounds were as effective on the axon as on other conducting membranes, indicating that a strong lipid barrier surrounds the squid axon.

TL;DR: Thiols should selectively protect normal cells against alkylating agents as a consequence of the higher concentration of the nucleophilic anionic form therein, and certain epoxides should be even more suitable for exploiting this tissue difference.

TL;DR: No parallelism could be traced between the locom motor stimulant effect of stereoisomers and their inhibition of monoamine oxidase, and only the threo derivatives display a locomotor stimulant action.

TL;DR: It is concluded that dithiazanine interferes with the transport of glucose in T. vulpis and, as a result, utilization of endogenous carbohydrate is increased and depletion of the carbohydrate stores and inability to utilize exogenous glucose brings about a decrease in the generation of energy-rich phosphate bonds.

TL;DR: It is suggested that nitrogen mustard halts the division process at a time after the replication of DNA that occurs in preparation for division, and inhibited cells nevertheless had up to twice the amount of DNA found in a normal, rapidly growing cell.