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Showing papers in "Biochemical Pharmacology in 1964"


Journal ArticleDOI
TL;DR: The duration of pentobarbital hypnosis, carisoprodol paralysis and strychnine toxicity was almost the same in immature (30 days old) and adult rats (60–150 days old), suggesting that the immature have a higher sensitivity to the drugs than the adult rats, but this is overshadowed by the higher metabolic activity in the immature rats.

241 citations


Journal ArticleDOI
TL;DR: The results of the present studies are of practical importance in the evaluation of the action of two compounds administered simultaneously or after short time intervals.

171 citations


Journal ArticleDOI
G. Hertting1
TL;DR: The delay of the urinary excretion of radioactivity following an injection of 3H-norepinephrine is caused by its binding in the tissues and slow release, and only negligible quantities of3H-iso-proterenol were found bound in tissues under similar conditions.

156 citations


Journal ArticleDOI
TL;DR: The data obtained from the use of specific amine oxidase inhibitors suggest that monoamine and diamine oxid enzyme of human plasma are separate enzymes.

153 citations


Journal ArticleDOI
TL;DR: Evidence is presented to show that certain of the observed inhibitions may be explained on a basis of interaction of alternative substrates and the close similarity of the Michaelis and inhibitor constants seen in the two systems argue strongly that a quantitative rather than a qualitative change is involved in the inductive process.

116 citations


Journal ArticleDOI
TL;DR: It was found, that the whole adrenergic neuron has the property to take up and concentrate noradrenaline and dopamine, and this suggests that monoamine oxidase is present in the neuron, and that the amines exist free or loosely bound in the cytoplasm, readily accessible to this enzyme.

105 citations



Journal ArticleDOI
TL;DR: The metabolism in vivo of several volatile anesthetics has been determined in the rat and their extent of conversion to 14 CO 2 and urinary metabolities labeled with 14 C or 36 Cl is presented.

100 citations


Journal ArticleDOI
TL;DR: The carboxypeptidase exists in the blood sera of mammals, birds, amphibia, and other animals, in lymph, and in human urine and thrombocytes, but not in erythrocytes, and the possible existence of several carboxypesptidases in blood is discussed.

95 citations


Journal ArticleDOI
TL;DR: It is concluded that the following anti-inflammatory drugs uncouple oxidative phosphorylation in the whole animal both in peripheral tissues such as cartilage and in those visceral tissuessuch as kidney and liver, which are concerned with the biosynthesis of sulphate esters.

92 citations



Journal ArticleDOI
TL;DR: Tolerance to barbital cannot be ascribed to decreased drug absorption, to increased excretion of the drug, or to a decreased permeability of the blood-brain barrier.

Journal ArticleDOI
TL;DR: The results suggest the two anions to be substrates to the same enzyme, theni trate reductase, and the effects of preincubation are interpreted as adaptive changes in a permeability controlling system for nitrate and perehlorate.

Journal ArticleDOI
TL;DR: The optic system of the chick can serve as a useful and subtle tool for neuropharmacological studies in general, and the data seem to support the view that this centrifugal system is inhibitory and may be associated with adaptation to the dark.

Journal ArticleDOI
TL;DR: The similarity of the effects of the erythrophleine and cassaine alkaloids and the digitalis glycosides on the Na-K ATPase system may explain the remarkable similarity between these two groups of compounds in pharmacological properties and in inhibitory effects on active cation transport.

Journal ArticleDOI
Glen R. Gale1
TL;DR: The antitumor agent, hydroxyurea, was shown to reduce the rate of incorporation of thymidine- 3 H into Ehrlich ascites tumor cells in vitro and this loss was not accompanied by gross cellular disorganization.

Journal ArticleDOI
TL;DR: The urine contained 13–14% of the isotope in the form of methionine, serine, and an adduct formed from cysteine and formaldehyde, which formed spontaneously by mixing normal urine and labeled formaldehyde.


Journal ArticleDOI
TL;DR: It is unlikely that these effects are causally involved in toxicity of these agents, but an exception may be the effect of HY in raising GABA levels, especially in mesencephalon-diencephalon.

Journal ArticleDOI
TL;DR: The results demonstrate the marked cross-resistance of houseflies selected only with dieldrin to other compounds having the hexachloronorbornene nucleus in common, and suggests that cyclodiene poisoning is at least partly reversible with the severity of the effect depending on the persistence of the poison in the tissues.

Journal ArticleDOI
TL;DR: Impaired seizures were accompanied by a decrease in γ-aminobutyric acid and increases in alanine, ammonia, lactic acid, and tyrosine, and in one instance by a generalized seizure (the excitatory effects being more prominent at higher dose levels).

Journal ArticleDOI
TL;DR: Physicochemical properties of phenylbutazone analogues were correlated with their physiological disposition, in particular with reference to species difference, while in man there exists a direct relationship between pKa and half-life, no such correlation was observed in dogs.

Journal ArticleDOI
John S. Evans1, Gordon D. Mengel1
TL;DR: Reversal of activity by deoxycytidine was demonstrated in mice in three tumor systems and preliminary studies showed that in certain tumor systems the availability of deoxyCytidine may be one of the limiting factors in tumor growth.

Journal ArticleDOI
TL;DR: A rapid and quantitative method for the assay of 5-hydroxytryptamine in whole blood based on the ability of carboxymethylcellulose to bind the free amine in lysed blood in the presence of protein is described.

Journal ArticleDOI
TL;DR: The results suggest that the inhibition takes place in the electron-transfer reactions chain between nicotinamide-adenine dinucleotide and cytochrome b, and papaverine and ethaverine show the greatest activity both in experiments with isolated gut and with rat liver mitochondria.

Journal ArticleDOI
TL;DR: It has been shown that the majority of the changes in the serum proteins are associated with inflammation, and those seen in human arthritis are discussed.


Journal ArticleDOI
TL;DR: 2,5-bis (1,1-dimethyl propyl) hydroquinone gave excellent protection against OHP toxicity in all tests, and several other antioxidants also protected against O HP toxicity but their potency and effectiveness varied for the different criteria of oxygen poisoning tested in the experiments.

Journal ArticleDOI
TL;DR: After pretreatment with reserpine, tetrabenazine, or tranylcypromine and after recovery from behavioral effects of these compounds, the response to ED 90 or threshold doses of LSD-25 was markedly enhanced and correlated with a change in levels of brain serotonin and norepinephrine.

Journal ArticleDOI
TL;DR: The stability of the drug metabolising enzymes of various preparations of rat liver microsomes has been investigated and the causes of the instability of these enzyme systems are discussed.