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Showing papers in "Biochemical Pharmacology in 1969"


Journal ArticleDOI
TL;DR: Evidence is presented concerning the nature of the substrate specificity of the monoamine oxidase (MAO) complex from rat liver and brain, utilising a nonhydrazine inhibitor, M & B 9302.

230 citations


Journal ArticleDOI
TL;DR: Soluble tryptophan hydroxylating enzymes have been obtained from both the beef pineal gland and rat brainstem and Tetrahydrobiopterin was more effective than 2-amino-4-hydroxy- 6,7-dimethyl-5,6,7,8 tetrahydropteridine as a cofactor for the enzymes.

208 citations


Journal ArticleDOI
TL;DR: Comparison of CCl 4 levels in the blood and liver of pretreated and control animals suggest that the toxic effects cannot be related to the action of unaltered C Cl 4, and strengthen the view that CCl 3 must be metabolised to cause cell damage.

202 citations


Journal ArticleDOI
TL;DR: While the temporal relationships of CCl 4 -induced hepatotoxicity are compatible with the lipid peroxidation hypothesis, the dosage relationship is weaker and the lack of qualitative similarity in the results obtained with chloroform is disturbing.

191 citations


Journal ArticleDOI
TL;DR: Experiments in ritro on six micro-organisms revealed that the alkaloids have pronounced antibacterial characteristics and from measurements of oxygen uptake by Staphylococcus aureus it has been deduced that the antibacterial activity of the alkAloids is bactericidal and not bacteriostatic.

180 citations


Journal ArticleDOI
TL;DR: The degree of binding over the entire range of therapeutic plasma drug concentration was relatively constant and the acetyl derivatives of DMI, NT and PT were much more bound than the parent compounds.

176 citations


Journal ArticleDOI
TL;DR: An extremely active microsomal epoxidasc has been obtained from larvae of the southern armyworm and optimal assay conditions in vitro have been established and maximum enzyme activity is associated primarily with the larval mid-gut.

163 citations


Journal ArticleDOI
TL;DR: In experiments in rats, the in vivo effect of pyrazole in doses of 0.07–8.82 m-mole/kg inhibited the elimination of ethanol by 20 to 90 per cent compared to the control experiments, and inhibition of ethanol metabolism was confirmed by studies with 14 C-1-ethanol, which showed a decrease in the excretion rate afterPyrazole.

158 citations


Journal ArticleDOI
TL;DR: In this article, the effect of fructose on adenine nucleotide metabolism was studied in rats in vivo by analyzing liver metabolite levels after intravenous fructose injections, and in vitro by measuring allantoin production by the isolated perfused liver after the addition of fructose to the perfusion medium.

146 citations



Journal ArticleDOI
TL;DR: A 0.1% solution of sodium phenobarbitone instead of normal drinking water causes maximal stimulation of enzyme activity and an increase in cytochrome P-450, of 7-fold over controls; there are also increases in liver weight and microsomal protein.


Journal ArticleDOI
TL;DR: Diet limitation which resulted in marked body weight loss in young rats had little influence on both the formation and the maintenance of the carrageenin granuloma.

Journal ArticleDOI
TL;DR: The carcinostatic and pharmacological properties of a new cytotoxic agent, 2,4-dinitro-5-ethyleneiminobenzamide (CB 1954), have been investigated and the effects on the haematopoietic system are not unduly severe and the pathological effects at the minimum toxic dose are manifest in the liver and urinary tract.

Journal ArticleDOI
TL;DR: It is suggested that ochratoxin A is hydrolyzed in vitro by carboxypeptidase A and a-chymotrypsin and possibly cathepsin C from lyosomes.

Journal ArticleDOI
TL;DR: The most likely interpretation for these findings is that CS2 causes a rapid alteration in the cytochrome P-450 leading to loss of its spectrum and of its activity in drug oxidation and that the altered Cytochrome (or its haem moiety) is lost from the damaged membranes at a slow rate.

Journal ArticleDOI
TL;DR: The findings suggest that the three responses to morphine may be closely related, and the concomitant daily administration of cycloheximide with morphine prevented the development of tolerance and physical dependence.

Journal ArticleDOI
TL;DR: The results suggest that carcinogenic aryldialkyltriazenes are dealkylated to form aryl-monoalkyltRIazenes as proximate carcinogens.

Journal ArticleDOI
TL;DR: Elevated calcium concentration prevents lithium-induced inhibition of norepinephrine-3 H release but has no effect on lithium inhibition of evoked release of serotonin- 3 H, and enhanced calcium levels did not reverse ouabain- induced inhibition of release of either monoamine.

Journal ArticleDOI
TL;DR: Sodium salicylate significantly reduced the synthesis of collagen in the granulomatous tissue without affecting non-collagen protein synthesis, and among the non-steroids tested, indomethacin and phenylbutazone failed to show any significant changes in the synthesis.

Journal ArticleDOI
TL;DR: Observations indicated that these hormones increased heart adenyl cyclase activity by different mechanisms and could be blocked by beta-adrenergic blocking agents.



Journal ArticleDOI
TL;DR: It was found that, although D 3 was the most active of the compounds tested in both systems, compounds having the side chain of D 3 and DHT 3 act preferentially in the ICA system, whereas compoundsHaving the side Chain of D 2 and D HT 2 act preferentialially inThe BCR system.


Journal ArticleDOI
TL;DR: In the convulsant rat, ultra-structural alterations of some nerve endings of the cerebral cortex were observed and altered nerve endings were preferentially found in the GAD-rich (nonaminergic) fraction of isolated nerve endings.

Journal ArticleDOI
TL;DR: Chromatography on Sephadex gel demonstrated that, although albumin has a high capacity for binding dexamethasone, the affinity constant of the steroid-protein complex is of a low order.

Journal ArticleDOI
TL;DR: Observations support the hypothesis that the adrenergic α-receptor may bear analogy to the “carboxyl” serine hydrolases.

Journal ArticleDOI
TL;DR: The enzymatic hydrolysis of the amide bond of phenacetin by rat liver, in vivo and in vitro, is inhibited considerably less by BNPP than the hydrolyses of acetanilide, monoethylglycine-2,6-xylidide and methyl butyrate, and another amidase may be involved in the deacetylation of phen acetin byRat liver.