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Showing papers in "Biochemical Pharmacology in 1985"


Journal ArticleDOI
TL;DR: It is suggested that the use of some or all of these homologous phenoxazone ethers will provide both a simple routine test for the characterization of several types of inducing agents and a powerful tool for investigating the biochemical basis for cyt.

1,280 citations


Journal ArticleDOI
TL;DR: The role of GSH in the expression of sensitivity to agents other than melphalan was examined and the patterns of both primary resistance and cross-resistance were compared following GSH depletion in these cell lines.

560 citations


Journal ArticleDOI
TL;DR: The results suggest that 3H-raclopride labels dopamine D-2 receptors with high specificity in the rat brain both in vitro and in vivo, and thus, that it should be a useful tool in studies of central dopamine D -2 receptors.

500 citations



Journal ArticleDOI
TL;DR: The dissimilar patterns of induction of the cytochrome P-450-dependent activities and the various conjugation activities may indicate that these xenobiotic metabolizing enzymes are differently regulated in the rainbow trout liver.

213 citations




Journal ArticleDOI
TL;DR: It is concluded that this slow reaction of Desferal with O2- is unlikely to influence the interpretation of experiments in which the chelator is used and the ability of desferal to react with hydroxyl radical is a far more likely source of error in the interpretations of results using this chelating agent.

185 citations


Journal ArticleDOI
TL;DR: PZ 51 (Ebselen) is capable of inhibiting ADP-Fe-induced lipid peroxidation in isolated hepatocytes, assessed by generation of low-level chemiluminescence, and the formation of alkanes and malondialdehyde.

157 citations


Journal ArticleDOI
TL;DR: In a comparative study the inhibition of microsomal lipid peroxidation induced by an Fe2+-ADP-complex and NADPH by naturally occurring isoflavones and their reduced derivatives has been examined and it is found that the isoflavanones are more active than the parent isofavones and the is oflavans are by far the most potent inhibitors.

151 citations


Journal ArticleDOI
TL;DR: It is found that NADH-dependent mitochondrial peroxidation--measured by the 2-thiobarbituric acid method--was stimulated by adriamycin as much as 4-fold, and that in submitochondrial particles freed of endogenous defenses against oxyradicals, lipidperoxidation was increased 7-fold by adRIamycin.

Journal ArticleDOI
TL;DR: Results suggest that diltiazem and verapamil may have the potential to cause drug interactions involving inhibition of drug biotransformation, as both drugs could prolong pentobarbital-induced sleeping times in mice at doses comparable to those used in man.



Journal ArticleDOI
TL;DR: Results strongly support direct interaction of miconazole with microsomal cytochrome P-450 in human placental microsomes with high affinity resulting in the inhibition of aromatase activity.

Journal ArticleDOI
TL;DR: Results suggest that [3H]nomifensine binds to a site on dopaminergic nerve terminals associated with the dopamine uptake pump in rat and rabbit striatal membranes.

Journal ArticleDOI
TL;DR: Phosphorylation of DHPG to mono-, di- and triphosphates by purified viral and cell enzymes was more rapid than that of acyclovir, yet acy Clovir triph phosphorylation was a much more potent inhibitor of herpes virus and cell DNA polymerases.

Journal ArticleDOI
TL;DR: It is concluded that the reported GSH peroxidase-like activity of ebselen, catalysing the reduction of 5-HPETE to 5-HETE, can not account for the findings and the lipoxygenase reaction itself apparently represents the site of inhibition of LTB4 formation by ebselsen.

Journal ArticleDOI
TL;DR: It is suggested that PL/Ca-PK, by virtue of the hydrophobic interactions required for the enzyme activation, may represent a potential site of action for the lipophilic antiestrogens, in addition to the commonly recognized intracellular estrogen receptors.

Journal ArticleDOI
TL;DR: No correlation was apparent between the intercalative mode of binding to DNA, regardless of base composition, and the pharmacological activity of these drugs and the possibility that this secondary type of binding may be responsible for the antitumor properties of the drugs is considered.

Journal ArticleDOI
TL;DR: In arteries, the endothelium becomes increasingiy difficult to remove as the vessel diameter decreases, and Dr. Furchgott and his colleagues coined the term “endothelium-delved relaxing factor” (EDRF) for the substance(s) which mediates the decrease in smooth muscle contraction.

Journal ArticleDOI
TL;DR: The mechanism by which the lipid peroxidation product 4-hydroxynonenal and several other homologous, yet non biogenic aldehydes inhibit proliferation of cultured Ehrlich ascites tumor cells has been studied.

Journal ArticleDOI
TL;DR: The data strongly support the hypothesis that the antitumor activity of epipodophyllotoxins is based on the ability to stimulate the formation of a cleavable complex between DNA topoisomerase and DNA.

Journal ArticleDOI
TL;DR: Findings show that CV-3988 is a specific antagonist of PAF at the receptor site(s) of platelets and, in these species, inhibits PAF-induced platelet aggregation by inhibiting the binding ofPAF to the "PAF receptor".

Journal ArticleDOI
TL;DR: Intravenously given N-acetylcysteine, methionine, GSH or GSSG restored liver glutathione levels of starved animals to the contents observed in the fed state, and the diurnal hepatic variation of GSH caused by the food intake habit of the animals may limit the capacity of the intracellular detoxication system.


Journal ArticleDOI
TL;DR: The inverse regulation of these activities, i.e. the depression of selenium-dependent glutathione peroxidase activity following sustained induction of glutathion transferases, may have direct implications for the toxicity of the polyhalogenated aromatic hydrocarbons.