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Showing papers in "Biochimica et Biophysica Acta in 1968"


Journal ArticleDOI
TL;DR: The cholesterol controls the fluidity of the hydrocarbon chains of the phospholipid by disruption of the crystalline chain lattice of the gel phase, and by inhibiting the flexing of chains in the dispersed liquid crystalline phase.

847 citations


Journal ArticleDOI
TL;DR: The liver membrane protein could not be detected in extracts of Morris hepatoma but was found to be present in a highly differentiated second generation hepatoma induced by diacetyl amino fluorene.

822 citations


Journal ArticleDOI
TL;DR: Comparisons of the permeability of the liposomes of phospholipids with asymmetric chains are much more permeable than those of lecithins with chains of equal length but with the same total number of paraffin carbon atoms suggests that, certainly at lower temperatures, the model structures are muchMore permeable.

591 citations


Journal ArticleDOI
TL;DR: The pancreatic enzyme shows a marked preference for anionic phospholipids such asosphatidic acid, cardiolipin and phosphatidyl glycerol, and acts stereospecifically on all common types of 3-sn-phosphoglycerides, regardless of chain length or degree of unsaturation.

522 citations


Journal ArticleDOI
TL;DR: The lecithins formed more expanded films than the phosphatidylethanolamines and this is interpreted in terms of differences in the size and orientation of the polar groups and this transition occuring in the bimolecular lamellae in water corresponds to the transition from condensed to expanded monolayer.

514 citations


Journal ArticleDOI
TL;DR: It is suggested that the potential may cause conformational changes in the membrane structure resulting in the observed loss of its semipermeable properties.

501 citations


Journal ArticleDOI
TL;DR: A model was proposed for the complex of the latter two phospholipids with Ca2+.

446 citations


Journal ArticleDOI
TL;DR: The results point to a great lability of the interactions of structural elements of the erythrocyte membrane responsible for the maintenance of biconcave shape to result from an equilibrium between opposite forces directed towards formation of crenated or cup cells, respectively.

433 citations


Journal ArticleDOI
TL;DR: Total phospholipid concentration in retina was relatively high, in vitreous body very low, and in iris, choroid, lens, cornea and sciera intermediate, and the concentrations of phosphatidyl glycerol, diphosphatidic acid, lysophosph atidyl choline and the unidentifiedospholipids were very low.

342 citations



Journal ArticleDOI
TL;DR: Results suggest that the Mg2+-dependent ATPase and the ( Na + + K + )-ATPase have the same molecular weight, and that it might be possible to estimate the molecular weight of enzymes in intact cells.



Journal ArticleDOI
TL;DR: When not fully saturated with iron, bovine, human and goat lactoferrins were bacteriostatic for Bacillus stearothermophilus and Bacillus subtilis in both the presence and absence of trace amounts of metals.

Journal ArticleDOI
TL;DR: It has been demonstrated that lignin is responsible for this adsorbed by a constituent of vegetable fibrous tissue and it is postulated that the binding has a “hydrophobic” character.

Journal ArticleDOI
TL;DR: Results suggest that digoxin binds with the phosphorylated conformation of the enzyme, and the mechanism of digoxin inhibition of the ATPase is explained by the stability of the digoxin-intermediate complex.

Journal ArticleDOI
TL;DR: The mitochondria were found to have maximal rates of amino acid incorporation in an ATP-supported system similar to those currently used with cytoplasmic ribosomes, and the antibiotics chloramphenicol, lincomycin, erythromycin, spiramycin, carbomycin and oleandomycin have been shown to inhibit specifically amino acid incorporated by the mitochondrial system.

Journal ArticleDOI
TL;DR: The results are consistent with the view that, despite their diverse origin and function and their chemical differences, plant and bacterial ferredoxins have similar characteristics as electron carriers.


Journal ArticleDOI
TL;DR: It is suggested that the extremely rapid enzymic reaction of GSH with lipid hydroperoxides breaks the autocatalytic chain reactions of lipid peroxidation and thus protects the vital cellular compounds from the effect of lipidPeroxides.

Journal ArticleDOI
TL;DR: Tl + has been found to replace K + in activation of the (Na + -K + )-sensitive ATPase of rabbit kidney and is unique in that it has an affinity approx.

Journal ArticleDOI
TL;DR: The chemical reactions between DNA and H2O2 or NH2OH, which at low concentration and in the presence of oxygen produces H2 O2, have been investigated using DNA and oligodeoxyadenylic acid.

Journal ArticleDOI
TL;DR: Cerebroside 3-sulfate was found to inhibit sulfatase activity with 2-hydroxy-5-nitrophenyl sulfate as substrate and vice versa; a result which indicates a common enzyme for both substrates.


Journal ArticleDOI
TL;DR: There is a corresponding decrease in lysine and hydroxylysine recoverable on hydrolysis, suggesting that the bond formed is relatively stable, and the implication of the results with respect to the natural cross-links in collagen is briefly discussed.

Journal ArticleDOI
TL;DR: An hypothesis is suggested whereby the selective transport of ions (X=) through bimolecular phospholipid membranes is performed by charged (C ± ) or uncharged (C) carriers.

Journal ArticleDOI
TL;DR: It has been suggested that a conformational change of the choline moiety from a co-planar to aCo-axial arrangement occurs during compression of saturated choline phospholipids and may contribute to the surface pressure and surface potential characteristics of monolayers of such substances and of lung extracts.

Journal ArticleDOI
TL;DR: Human skin collagenase also acts on collagen in the native fibrillar form at 37° with a pH optimum of 7 to 8.0, and is inhibited by low concentrations of EDTA, cysteine and human serum but not by soybean trypsin inhibitor.

Journal ArticleDOI
TL;DR: A technique that allows the direct quantitative estimation of H2O2 in polymorphonuclear leukocytes has been developed and indicates the presence of a non-dialyzable catalase-limiting component(s) in the polymorphon Nuclear Leukocytes.

Journal ArticleDOI
TL;DR: Chromatography of a number of water-soluble homo- and heteropolypeptides on hydroxyapatite columns has shown that only those containing carboxyl groups (poly- l -aspartate, poly-L -glutamate and their copolymers) are adsorbed by hydroxyAPatite.