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Showing papers in "Biochimica et Biophysica Acta in 1987"


Journal ArticleDOI
TL;DR: It is demonstrated that the phase behaviour of phosphatidylcholine-cholesterol mixtures can be rationalized using only a few basic assumptions, suggesting that the occurrence of specific phosphatido-ch cholesterol complexes is not implied by the experimental thermodynamic data.

1,004 citations


Journal ArticleDOI
TL;DR: The changes in concentrations of the plasma antioxidants during peroxyl radical attack show that the first line of defense is provided by the plasma sulfhydryl groups, even urate being spared during the initial stages of the reaction.

882 citations



Journal ArticleDOI
TL;DR: The tendency of certain lipids to self-associate, their asymmetric distribution in SUVs, their preferential association with cholesterol in non-cocrystallizing mixtures, their temperature-induced transitions to the hexagonal phase and their inhibitory effect on penetration of hydrophobic residues of proteins partway into the bilayer can all be explained by their participation in intermolecular hydrogen bonding interactions.

723 citations


Journal ArticleDOI
TL;DR: Primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro and it was found that lipoproteins contained in these cells may function to redistribute lipid and regulate cholesterol homeostasis within the brain.

669 citations


Journal ArticleDOI
TL;DR: In this article, the balance between light-dependent reactions and electron consuming reactions in intact sunflower leaves was varied by changing the incident light-flux at constant intercellular CO2 concentration.

633 citations


Journal ArticleDOI
TL;DR: The influence of enzymes such as lecithin-cholesterol acyltransferase and hepatic lipase on the direction of net transfer of free cholesterol between lipoproteins and cells can be understood in terms of their effects on the pool sizes and the rate constants for influx and efflux.

536 citations



Journal ArticleDOI
TL;DR: It is proposed that prior interaction between the toxin and cell-specific plasma membrane recpetors is necessary before these toxins can insert into, or interact with, the membrane.

463 citations


Journal ArticleDOI
TL;DR: The behavior of carotenoids in photosynthetic bacterial reaction centers and light-harvesting complexes is correlated with data from experiments carried out on carOTenoids and model systems in vitro.

439 citations


Journal ArticleDOI
TL;DR: Respiratory parameters of cardiac mitochondria were determined in the bundles of cardiac fibers skinned by using saponin that specifically removed sarcolemma, but left intracellular structures intact.


Journal ArticleDOI
TL;DR: The cellular localization of the glycosylation reactions is summarized and the problem of transmembrane translocation of the sugar precursors at the ER and the Golgi is discussed.


Journal ArticleDOI
TL;DR: In this article, the minimal turnover time for in vivo electron transport from water to CO 2 was calculated from oxygen flash yields and steady-state light-saturated photosynthetic rates in the marine chlorophyte, Dunaliella tertiolecta, cultured at different growth irradiance levels.

Journal ArticleDOI
TL;DR: Zinc alone affords no protection, but a high degree of stabilization is achieved when zinc is added to a sugar solution, even when the sugar is at a concentration at which, by itself, it is totally ineffective.

Journal ArticleDOI
TL;DR: It is suggested that the haptoglobins play an important antioxidant role in vivo by preventing iron-stimulated formation of oxygen radicals.



Journal ArticleDOI
Anna Seelig1
TL;DR: It is suggested from this analogy that the binding of dibucaine does not change the internal pressure in the bilayer phase, at least not in the concentration range of physiological interest (0-2 mM dibukaine) but induces a lateral expansion.

Journal ArticleDOI
TL;DR: Compared with previously published data on the cytosolic levels of phosphate and metabolic intermediates, it is shown that the reactions catalysed by pyrophosphate: fructose-6-phosphate phosphotransferase and UDP-glucose pyroph phosphorylase are close to the thermodynamic equilibrium and, thus, freely reversible in vivo.

Journal ArticleDOI
TL;DR: It is suggested that thiols react with redox metal, generating thiol- and oxygen-derived free radicals that promote modification of LDL in media lacking in redox metals.

Journal ArticleDOI
TL;DR: The phenomenological similarity of the cell and lipid membrane breakdown indicates that pores developed during the electrical breakdown of biological membranes arise in their lipid matrices.

Journal ArticleDOI
TL;DR: An oxygen-evolving Photosystem II reaction center complex was characterized by using both biophysical and biochemical techniques and revealed that cytochrome b-559 has been converted to its low-potential form and that Ca 2+ and Cl-, not the 17 and 23 kDa proteins, are the cofactors required for the generation of the multiline signal which is associated with the S 2 state.

Journal ArticleDOI
TL;DR: Good agreement was also found between the experimental and calculated values of K'Ca for the temperature and ionic strength dependence of BAPTA and dibromo-BAPTA, which agree well with those in the literature and with the calculated values.

Journal ArticleDOI
TL;DR: A consensus L1 is described; that is, those attributes that are thought to be characteristic of all known Lls, which appear to belong to a subclass of retrotransposons and to amplify by a process that includes an RNA intermediate.


Journal ArticleDOI
TL;DR: It is shown that the inhibitory effect of intracellular calcium on spin-labeled aminophospholipid translocation is partly due to the ATP depletion, which follows the increased consumption by the calcium pump.

Journal ArticleDOI
TL;DR: This is the first demonstration that superoxide dismutase is glucosylated in erythrocytes and that the glucOSylation leads to the inactivation of the enzyme.

Journal ArticleDOI
TL;DR: Results indicate that ubiquinone is synthesized not only in mitochondria, but also on the endoplasmic reticulum of rat liver, and the spectral and chromatographic properties of microsomal ubiquin one were identical to those of its mitochondrial counterpart.