Showing papers in "Biochimica et Biophysica Acta in 1995"

TL;DR: A brief review of current knowledge concerning some biochemical, physiological and medical aspects of the function of ubiquinone (coenzyme Q) in mammalian organisms can be found in this article.

TL;DR: An endocytosis model of DNA delivery by cationic liposomes is proposed in which the principal function of the chase liposome is to destabilize the endosome membrane and allow the release of DNA into the cytosol.

TL;DR: It is suggested that folate targeting constitutes a possible mechanism for improving the specificity of PEG-coated liposomes for cancer cells.

TL;DR: It is concluded that ROS and NO are important physiological reactants in mitochondria and become toxic only when present in excessive amounts.

TL;DR: Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging.

TL;DR: This review summarizes recent advances in the molecular characterization of prostanoid receptors and identifies multiple isoforms of PGE receptor EP3 subtype that differ in the efficiency of G protein activation, in the specificity of coupling to G proteins or in sensitivity to desensitization.

TL;DR: It is demonstrated that the presence of collagen results in the appearance of a series of characteristic absorptions which may be mis-assigned as DNA phosphate absorptions, with implications for the diagnosis of disease states by IR spectroscopic methods.

TL;DR: In this paper, 2.5-dibromo-3-methyl-6-isopropyl-p-benzoquinone was used for reductase.

TL;DR: It is demonstrated that binding to the cell surface is insufficient for cationic liposome-cell fusion and that uptake into the endocytic pathway is required for fusion to occur.

TL;DR: A flocculating protein from the seeds of Moringa oleifera Lam was isolated by extraction with phosphate buffer followed by cation exchange chromatography and Amino acid analysis and sequencing showed high contents of glutamine, arginine and proline, and a total of 60 residues.

TL;DR: Candida antarctica lipase A and B expressed interfacial activation, but the activation was not as prominent as for Humicola lanuginosa lipase (HLL), and the structural basis for the activation of CALA is unknown.

TL;DR: Efficient remote-loading of doxorubicin was found for immunoliposomes in which Ab was attached at the PEG terminus, and these immunolIPosomes achieved good specific binding to their target cells.

TL;DR: A new methodology for attaching monoclonal antibodies to the terminus of PEG on S-liposomes is developed and the resulting S-immunoliposomes showed efficient drug remote loading, slow drug release rates and increased survival times in circulation compared to liposomes lacking PEG.

TL;DR: The effects of cholesterol on the thermotropic phase behavior of annealed and unannealed aqueous dispersions of dipalmitoylphosphatidylcholine (DPPC) using high-sensitivity differential scanning calorimetry (DSC), concentrating particularly on the cholesterol concentration range from 0 to 20 mol%.

TL;DR: Experimental evidence suggests that multiple forms of thymocyte apoptosis can be inhibited by free radical spin traps, spin probes and thiol reductants, and that this inhibition correlates with a lower oxidative burden within the treated cells.

TL;DR: Transduction of growth signals by G protein-coupled receptors such as those for thrombin or bombesin also requires PtdIns(4,5)P2 hydrolysis, which, in this instance, is mediated by PLC-beta isozymes.

TL;DR: MUC1 has a highly varied structure because of its polymorphism, qualitative and quantitative variations in its glycosylation between tissues, individuals and species, and differences due to divergence in the nucleotide sequences among species.

TL;DR: Characterization of putative DREs in various constructs with either a native or TK promoter suggests that both VDREs are required for the optimal induction of 24-hydroxylase expression by 1,25-(OH)2D3.

TL;DR: Signaling by cell adhesion receptors may involve aspects that impinge on previously known signaling pathways including the RTK/Ras pathway and serpentine receptor/G protein pathways, however, novel aspects of signal transduction involving cytoskeletal assemblies may also be critical.

TL;DR: The cryo-TEM analysis suggests that an excess of lipid in terms of charge, leads to entrapment of the DNA molecules between the lamellas in clusters of aggregated multilamellar structures.

TL;DR: The approach provides a simple means of conjugating antibodies directly to the distal end of PEG which is already bound to the liposome membrane, and should contribute to the development of superior targetable drug delivery vehicles for use in diagnostics and therapy.