Showing papers in "Biochimica et Biophysica Acta in 1996"

TL;DR: A great deal of research effort is now concentrated on two aspects of ferritin: its functional mechanisms and its regulation and the apparent links between iron and citrate metabolism through a single molecule with dual function are described.

TL;DR: Reports on the presence of HPV infections in cancers of the oral cavity, the larynx, and the esophagus further emphasize the importance of this virus group as proven and suspected human carcinogens.

TL;DR: This review focuses on developments in the last 6-7 years, and cites data resulting from the isolation and characterization of SRC mutants, crystallographic studies of the structures of SH2, SH3 and tyrosine kinase domains, biochemical studies of Src kinase activity and binding properties, and the biology of transgenic and knockout mouse strains.

TL;DR: In rodents, a PPAR alpha-mediated change in the expression of genes involved in fatty acid metabolism lies at the basis of the phenomenon of peroxisome proliferation, a pleiotropic cellular response, mainly limited to liver and kidney and which can lead to hepatocarcinogenesis.

TL;DR: It is speculated that structural differences in the substrate-activation site (a 'blue', type 1 copper center) control the redox potential range as well as substrate specificity, and the cystine content contributes to stability.

TL;DR: The results indicated that the ability of those compounds to protect synaptosomes from the damage of lipid peroxidation initiated by Fe2+/Fe3+ was dependent not only on their iron-chelating activity and free-radical scavenging activity, but also on the stability of their semiquinone free radicals.

TL;DR: Ser/Thr and Tyr specific protein kinases and positive and negative specificity determinants: much ado about nothing?

TL;DR: The key features of pore regulation are reviewed, the recent demonstrations that the MTP is controlled by the membrane potential, and how MTP regulation by cellular pathophysiological effectors (such as cytosolic [Ca2+] transients, oxidative stress, and changes in the concentration of polyamines, nitric oxide, and metabolites of both the sphingomyelin and phospholipase A2 pathways) might take place in vivo are elaborate.

TL;DR: The antioxidants, N-acetyl-L-cysteine (NAC), L-ascorbic acid, alpha-tocopherol, catalase and superoxide dismutase, all effectively prevented curcumin-induced apoptosis, suggesting that curcuming-induced cell death was mediated by reactive oxygen species.

TL;DR: It is proposed that the main route of entry of cationic liposome-DNA complexes into cells is by endocytosis, and occasionally, liposomes may enter the nucleus by fusion with the nuclear envelope, creating vesicular and reticular intranuclear membranes.

TL;DR: Fine tuning of the acute phase response appears to be regulated at all stages: primary signals, kinase cascades, transcription factors, mRNA stability and translation, cytokine precursor processing, secretion and bioavailability, which makes possible designing of specific inhibitors of cytokine synthesis as potential therapeutic drugs.

TL;DR: It is demonstrated that ultraviolet B (UVB) radiation stimulates increased expression of the proopiomelanocortin (POMC) gene which is accompanied by production and release of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropin (ACTH) by both normal and malignant human melanocytes and keratinocytes.

TL;DR: The application of the supported bilayers to study ion transport through channel-forming peptides is used for the reconstitution of gramicidin D channels and it is verified that the peptide is in its channel conformation.

TL;DR: The ability of caffeine to inhibit oxidative damage induced by these reactive species in membranes suggest one more positive attribute of caffeine, whose daily intake as coffee may be considerable in most populations.

TL;DR: This work examines how the chemistry of its key reactants toward biologically important molecules relate to DNA damage and cytotoxicity in the inflammatory process and suggests that NO may play an important role in currently accepted models of multistage carcinogenesis.

TL;DR: It is demonstrated that rat hearts have a high AMPK activity, comparable to that found in liver, which could be stimulated up to 3-fold by 5'AMP, and low ACC activity could be reversed if ACC was extracted from hearts in the absence of phosphatase inhibitors, suggesting that phosphorylation of ACC decreased enzyme activity.

TL;DR: It is shown that internalization of folate-macromolecule conjugates by receptor-bearing KB cells can be blocked by agents that specifically inhibit caveolae assembly or internalization such as nystatin and phorbol-12-myristate acetate (PMA).

TL;DR: The SM pathway represents a potentially valuable focal point for therapeutic control of immune responses, perhaps for either enhancement of the activity of T cells in the elimination of tumors, or the down-regulation of lymphocyte function in instances of autoimmune disease.