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Showing papers in "Biochimica et Biophysica Acta in 1998"


Journal ArticleDOI
TL;DR: In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death.

1,392 citations


Journal ArticleDOI
TL;DR: A review of the data subset referring to phosphatidylcholine phase behavior reflecting changes in lipid chain length, unsaturation, asymmetry and branching, type of chain-glycerol linkage (ester, ether, amide), and position of chain attachment to the glycerol backbone are presented.

1,040 citations




Journal ArticleDOI
TL;DR: The implication of mitochondria in apoptosis has important consequences for the understanding of the normal physiology of apoptosis, its deregulation in cancer and degenerative diseases, and the development of novel cytotoxic and cytoprotective drugs.

834 citations


Journal ArticleDOI
TL;DR: Platelet-derived growth factor exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors, and a number of different signaling pathways are initiated leading to cell growth, actin reorganization migration and differentiation.

767 citations


Journal ArticleDOI
TL;DR: Fast repetition rate (FRR) fluorescence as mentioned in this paper applies a sequence of subsaturating excitation pulses ('flashlets') at microsecond intervals to induce fluorescence transients, which can be extremely flexible and allow the generation of both single-turnover (ST) and multiple-transover (MT) flashes.

763 citations


Journal ArticleDOI
TL;DR: Anti-apoptotic Bcl-2 family proteins function as gatekeepers to prevent the release of both cyt c and AIF and may also be involved in the direct binding of Apaf molecules as regulatory elements further downstream from the mitochondrial apoptotic signals.

717 citations


Journal ArticleDOI
TL;DR: It is concluded that, in spite of much effort, the authors still do not understand the basic molecular mechanisms underlying surfactant's rapid adsorption to the air-water interface.

700 citations


Journal ArticleDOI
TL;DR: The lipid composition of mammalian surfactant and the techniques that have been utilized to study the involvement of these lipids in reducing the surface tension at an air-liquid interface, the main function of pulmonary surfactants are described.

688 citations


Journal ArticleDOI
TL;DR: The structure-function relationships delineating the activation process of class I PI3Ks involving various domains of adapter subunits, Ras, and interacting proteins are summarized and the role ofPI3K signaling in multicellular organisms is elucidated.

Journal ArticleDOI
TL;DR: Experimental evidence of respiratory chain defects and of accumulation of multiple mtDNA deletions with ageing is in accordance with the mitochondrial theory, although some other experimental findings are not directly ascribable to its postulates.

Journal ArticleDOI
M. Flint Beal1
TL;DR: A potential pivotal role for mitochondrial dysfunction in neurodegenerative diseases is gaining increasing acceptance and therapeutic approaches include methods to buffer intracellular ATP and to scavenge free radicals.

Journal ArticleDOI
TL;DR: It is concluded that hydrophobic mismatch can strongly affect protein and lipid organization, but that the precise consequences depend on the individual properties of the proteins and lipids.

Journal ArticleDOI
TL;DR: A novel mode of action is discussed in detail, i.e., the formation of a dynamic peptide-lipid supramolecular pore, which allows the mutually coupled transbilayer transport of ions, lipids, and peptides per se.

Journal ArticleDOI
TL;DR: The high-conductance state of the PTP, which was shown to play a pivotal role in the course of excitotoxic and thapsigargin-induced cell death, might result from a Ca2+-dependent conformational shift of the low- conductance state, normally participating in the regulation of cellularCa2+ homeostasis as a pH-operated channel.

Journal ArticleDOI
TL;DR: The present review describes the topoisomerase I catalytic mechanisms with particular emphasis on the cleavage complex that represents the enzyme's catalytic intermediate and the site of action for camptothecins.

Journal ArticleDOI
TL;DR: The present study shows the existence of a microcystin-LR glutathione conjugate formed enzymatically via soluble glutATHione S-transferase in various aquatic organisms and appears to be the first step in the detoxication of a cyanobacterial toxin in aquatic organisms.

Journal ArticleDOI
TL;DR: The structural properties of lipids in a cell biological context is discussed, including those associated to rafts, which can act as organizers and can modulate raft size and function.

Journal ArticleDOI
TL;DR: This work develops a general framework for thinking about the thermodynamics of membrane protein stability that centers on interfacial interactions and describes an experimentally determined whole-residue interfacial hydrophobicity scale that reveals the central role of the peptide bond in partitioning and folding.

Journal ArticleDOI
TL;DR: The mechanism of action of eukaryotic topoisomerase II and topoisomersase II-targeted drugs is discussed.

Journal ArticleDOI
TL;DR: The quaternary structures of these proteins form the basis of a higher level of specificity, where the spacing between individual epitopes of multivalent carbohydrates becomes important, and is of relevance for their effects on the biological activities of cells such as mitogenic responses.

Journal ArticleDOI
TL;DR: Roles of individual desaturases in temperature acclimation and principles of regulation of the desaturase genes are discussed.

Journal ArticleDOI
TL;DR: The carrier-mediated transcutaneous insulin delivery is unlikely to involve shunts, lesions or other types of skin damage, and is inferred to be transported into the body between the intact skin cells with a bio-efficiency of at least 50% of the s.c. dose action.

Journal ArticleDOI
TL;DR: Evidence that multiple, probably non-endocytic mechanisms are involved in the uptake into mammalian cells of the alpha-helical amphipathic model peptide FLUOS-KLALKLALKALKAALKLA-NH2 (I) is presented.

Journal ArticleDOI
TL;DR: The evidence for the MPT being a major factor in the transition from reversible to irreversible injury during reperfusion of a heart following a period of ischaemia is summarised and the evidence for whether cell death occurs by necrosis or apoptosis is discussed.

Journal ArticleDOI
TL;DR: The compounds that inhibit the NADH–ubiquinone reductase activity of complex I are classified according to three fundamental types of action on the basis of available evidence and recent insights.

Journal ArticleDOI
TL;DR: The elastic (reversible) properties, thermal expansion, compressibility and heat capacity, are correlated with the entropy, volume, and the coupling between entropy and volume fluctuations respectively and the experimental approaches that can be used to measure these quantities are reviewed.

Journal ArticleDOI
TL;DR: Electrochemical properties and reactivities of the two mediators 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) and 1-hydroxybenzotriazole (HBT) were studied and their intermediates responsible for lignin oxidation were characterized.

Journal ArticleDOI
TL;DR: J. Morre, Ž .