Showing papers in "Biochimica et Biophysica Acta in 2001"

TL;DR: The emphasis of this article is primarily on the deleterious actions of radicals generated on proteins, and their mechanisms of action, rather than on enzymatic systems where radicals are deliberately formed as transient intermediates.

TL;DR: The properties of the hLAT1/h4F2hc complex would support the roles of this transporter in providing cells with essential amino acids for cell growth and cellular responses, and in distributing amino acid-related compounds.

TL;DR: The sequence- Specificity and structure-specificity relationships described may provide useful pointers for rational protein engineering.

TL;DR: The NO inhibition of cytochrome oxidase may be involved in the physiological and/or pathological regulation of respiration rate, and its affinity for oxygen.

TL;DR: This review will focus upon recent findings providing insight into the mechanisms by which FAK transmits biochemical signals and elicits biological effects.

TL;DR: It is concluded that UCP1 is unique amongst the uncoupling proteins and is the only protein able to mediate adaptive non-shivering thermogenesis and the ensuing metabolic inefficiency.

TL;DR: It is found that the molecular forms of apelin differ among respective tissues: apelin molecules with sizes close to apelin-36 were major components in the lung, testis, and uterus, but both long and short forms were detected in the mammary gland.

TL;DR: In this paper, the X-ray structure of photosystem I at a resolution of 2.5 A O shows the location of the individual subunits and cofactors and provides new information on the protein-cofactor interactions.

TL;DR: It is proposed that the Archaea domain acquired terminal oxidases by gene transfer from the Gram-positive bacteria, implying that these enzymes were not present in the last common ancestor before the divergence between Archaea and Bacteria.

TL;DR: A novel formulation process that utilizes an ionizable aminolipid and an ethanol-containing buffer system for encapsulating large quantities of polyanionic ODN in lipid vesicles and forms 'stabilized antisense-lipid particles' (SALP), which is believed to represent a viable candidate for systemic applications involving nucleic acid therapeutics.

TL;DR: HTLR10 mRNA is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil, and Expression analysis of cell lines indicates a predominance in a variety of immune cell types, and is preferentially expressed in tissues and cells involved in immune responses.

TL;DR: In this review aspects of filamin structure, its splice variants, binding partners and biological function will be discussed.

TL;DR: The kinetic and chemical mechanisms of the carnitine acyltransferases are discussed in relation to the different inhibitors under study for their potential to control diseases of lipid metabolism.

TL;DR: Detailed comparison between alpha-helical and beta-barrel proteins showed many qualitative differences in residue distributions, suggesting that there may be subtle differences in the factors stabilising beta- barrels in bacterial outer membranes andalpha-helix bundles in all other membranes.

TL;DR: Diclofenac association with ultradeformable carriers permits it to have a longer effect and to reach 10-times higher concentrations in the tissues under the skin in comparison with the drug from a commercial hydrogel, suggesting that dicl ofenac in Transfersomes has the potential to replace combined oral/topical dic lofenacs administration in humans.

TL;DR: This review focuses on the factors controlling the transition from G(2) phase to mitosis and the pathways contributing to the DNA damage checkpoints in these phases of the cell cycle.

TL;DR: A direct comparison of the energy transfer and trapping properties of the PS I core complexes of cyanobacteria bear a large resemblance to the core complex of plants, and this results in a transmembrane electrochemical gradient that can be used to produce ATP.

TL;DR: It may well be that the inherent flexibility of the HMGI/Y proteins, combined with their ability to undergo reversible disordered-to-ordered structural transitions, has been a significant factor in the evolutionary selection of these proteins for their functional role(s) in cells.

TL;DR: This mini-review focuses on recent experimental results and questions, which came up since the last more comprehensive reviews on the subject of electron transfer in photosystem I (PS I), and relates the kinetic results to new structural data of the PS I reaction centre.

TL;DR: The transfection mechanism was investigated, and it was found that plasmid/chitosan complexes most likely condense to form large aggregates (5-8 microm), which absorb to the cell surface, which absorbs to thecell surface.

TL;DR: The applicability of molecular imprinting, a method that allows the preparation of biomimetic compounds (artificial receptors and antibodies), is extended by the epitope approach, and it is demonstrated that although other parts of peptides can influence the process of molecular recognition, the polymers imprinted with a short peptide efficiently recognize both the template and larger peptides that possess the same C-terminal part of the structure.

TL;DR: The osteopontin receptor integrin αVβ3 contributes not only to tumor cell dissemination, but also to angiogenesis and osteolysis in bone metastases as mentioned in this paper.

TL;DR: In this paper, the NhaA 2D crystals were analyzed by cryoelectron microscopy and a density map at 4 A resolution was obtained and a 3D map was reconstructed.

TL;DR: The influence of CPPs on cellular 2-[(3)H]deoxyglucose-6-phosphate leakage is characterized and the membrane-disturbing potential appears to be correlated with the hydrophobic moment of the peptides.

TL;DR: The effects of the carotenoids beta-carotene and astaxanthin on the peroxidation of liposomes induced by ADP and Fe(2+) were examined, and the efficient antioxidant activity of astxanthin is suggested to be due to the unique structure of the terminal ring moiety.

TL;DR: Although the alternative components are non-energy conserving, their organisation within the fungal electron transfer chain ensures that the transfer of electrons from NADH to molecular oxygen is generally coupled to proton translocation through at least one site.

TL;DR: It is suggested that LEA proteins may play a role together with sugars in the formation of a tight hydrogen bonding network in the dehydrating cytoplasm, thus conferring long-term stability.

TL;DR: Through regulating actin cytoskeleton organization and membrane trafficking, phosphoinositides play crucial roles in a variety of cell functions such as growth, polarity, movement, and pattern formation.

TL;DR: A new amphiphilic PEG derivative, pNP-PEG-DOPE, which readily incorporates into liposomes via its PE residue, and easily binds primary amino group-containing ligands via its water-exposed pNP groups, forming stable and non-toxic urethane (carbamate) bonds could serve as a very convenient tool for protein attachment to the distal ends of liposome-grafted PEG chains.