Showing papers in "Biochimica et Biophysica Acta in 2007"

TL;DR: This review discusses the application of infrared spectroscopy to the study of proteins by focusing on the mid-infrared spectral region and theStudy of protein reactions by reaction-induced infrared difference spectroscopic.

TL;DR: The Raf/MEK/ERK pathway has different effects on growth, prevention of apoptosis, cell cycle arrest and induction of drug resistance in cells of various lineages which may be due to the presence of functional p53 and PTEN and the expression of lineage specific factors.

TL;DR: The p38MAPK pathway is a key regulator of pro-inflammatory cytokines biosynthesis at the transcriptional and translational levels, which makes different components of this pathway potential targets for the treatment of autoimmune and inflammatory diseases.

TL;DR: It is postulate that most types of environmental stress inhibit the fixation of CO(2) with the resultant generation of ROS, which, in turn, inhibit protein synthesis, which is required for the repair of PSII.

TL;DR: Recent progress on molecular mechanisms of formation of invasive protrusions used by tumor cells, such as lamellipodia and invadopodia, with regard to the functions of key regulatory proteins of the actin cytoskeleton; WASP family proteins, Arp2/3 complex, LIM-kinase, cofilin, and cortactin are summarized.

TL;DR: Under conditions commonly used for cholesterol extraction, cyclodextrins may remove cholesterol from both raft and non-raft domains of the membrane as well as alter the distribution of cholesterol between plasma and intracellular membranes.

TL;DR: Mechanisms that cooperate to direct MEK-ERK signals to their appropriate downstream destinations are described and shed light not only on the regulation of normal cell proliferation, but also on mechanisms of oncogenic transformation.

TL;DR: In the past few years many experiments showed that tumor-associated alterations can be detected at the DNA and RNA level, and laid the foundation for the development of assays for an early detection of cancer as well as for other clinical means.

TL;DR: How global demethylation of repeat sequences including transposable elements and the site-specific hypomethylation of certain genes might contribute to the deleterious effects that ultimately result in the initiation and progression of cancer and other diseases is considered.

TL;DR: The classical as well as the recently discovered P450 redox systems are compiled in this paper and classified according to their composition.

TL;DR: This review focuses on the spatio-temporal control of ERK signaling, on the key cellular components linking extracellular signals to the induction and activation of cell cycle events controlling G1 to S-phase transition and on the role of ERk in the growth factor-independent G2/M phase of the cell cycle.

TL;DR: This review highlights recent developments aimed at deciphering the molecular interplay between cell death pathways as well as their possible therapeutic exploitation in photosensitized cells.

TL;DR: What is known about the structure and mechanism of activation of GPCRs is reviewed focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor.

TL;DR: Recent advances and new insights about MAPK-based signaling that have been made through studies in yeast are highlighted, which provide lessons directly applicable to, and that enhance the understanding of,MAPK-mediated signaling in mammalian cells.

TL;DR: The involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling, which contributes to disease progression.

TL;DR: It is suggested that drugs that target the oxidative pathways in AD could have genuine therapeutic efficacy and current therapeutic strategies using metal chelators such as clioquinol and desferrioxamine have had some success in altering the progression of AD symptoms.

TL;DR: In conclusion, TGF-beta signaling is intimately implicated in tumor development and contributes to all cardinal features of tumor cell biology.

TL;DR: Identifying the mechanism of action of peroxisome proliferator-activated receptors should help promote the understanding of the physiologic roles that PPARs play in immunity and contribute to the development of new therapeutic agents.

TL;DR: Fluorescence markers effective for identification of coexisting macroscopic membrane phases in ternary lipid systems composed of phospholipids and cholesterol are found.

TL;DR: This review presents the current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease and describes JNK/SAPK involvement in proliferation, apoptosis, motility, metabolism and DNA repair.

TL;DR: The biochemical properties of RAS proteins are summarized, the evolution of Ras signaling is traced down, and an overview of the spatio-temporal activation of major RAS isoforms is presented.

TL;DR: In this review, what is currently known about enzymes involved in cellular fatty acid synthesis and elongation is summarized, potential links between fatty acid metabolism, physiology and cellular regulation are discussed, and multiple levels of control may exist to ensure proper fatty acid composition and homeostasis.

TL;DR: Two cellular outcomes of growth factor action, namely proliferation and migration, are critically regulated by MAPKs and the underlying molecular mechanisms are described and detailed.

TL;DR: The antimicrobial action of the ceragenins correlates better with the content of phosphatidylethanolamine in the bacterial membrane than whether or not the bacteria has an outer membrane, suggesting that the bacterial lipid composition can be an important factor in determining the sensitivity of bacteria to antimicrobial agents.

TL;DR: The review will summarize the known PPAR kinases that directly act on these receptors, the sites affected and the result of this modification on receptor activity.

TL;DR: A number of more complex P450 reactions also occur, and these can be understood largely in the context of the basic chemical mechanisms and subsequent rearrangements.

TL;DR: Issues as well as a variety of therapeutic options envisioned to influence tumour cell growth, metastasis and resistance, including kinase inhibitors, anti-integrin antibodies or RNA interference, will be summarized and discussed in this review.

TL;DR: The ever increasing map of functional interactions for GRK proteins is described as a basis to better understand its contribution to cellular processes.

TL;DR: Some of the major proposed functions for PrP(C), including protection against apoptotic and oxidative stress, cellular uptake or binding of copper ions, transmembrane signaling, formation and maintenance of synapses, and adhesion to the extracellular matrix are summarized.

TL;DR: Channelopathias for which mutations in TRP channels that induce "loss-" or "gain-of-function" of the channel and can be considered "disease-causing" have been identified are identified and the role of TRPs will be further elucidated in complex diseases of the intestinal, renal, urogenital, respiratory, and cardiovascular systems.