Showing papers in "Biochimica et Biophysica Acta in 2008"

TL;DR: The binding interactions of the most studied proteins that occur within each junctional complexes and possible modes of regulation of these interactions are discussed, and the different mechanisms that connect and regulate interactions with the actin cytoskeleton are discussed.

TL;DR: Various studies on different cationic antimicrobial peptides that exhibit cytotoxic activity against cancer cells are reviewed and the suitability of cancer cell-targeting AMPs as cancer therapeutics is discussed.

TL;DR: Recent advances in nucleotide-releasing and purine-converting pathways in the vasculature are summarized, with particular emphasis on the nucleotidases of ecto-nucleoside triphosphate diphosphatase/phosphodiesterase family.

TL;DR: The Wood-Ljungdahl pathway of CO(2) fixation involves this type of stepwise process and has intrigued chemists, biochemists, and microbiologists for many decades.

TL;DR: The concepts evolved from these findings and first tentative molecular models for homophilic interactions may explain the different functional contribution of the two extracellular loops at tight junctions.

TL;DR: This review analyzes how the crosstalk of protein kinase C,protein kinase A, myosin light chain kinase, mitogen-activated protein kinases, phosphoinositide 3-kinase and Rho signaling pathways is involved in TJ regulation triggered by diverse stimuli.

TL;DR: Ongoing studies will enable targeting of TGF-beta superfamily signaling pathways for the chemoprevention and treatment of human disease.

TL;DR: Pairs of fusion and fission allow for the reorganization and sequestration of damaged mitochondrial components into daughter mitochondria that are segregated from the networking pool and then becoming eliminated by autophagy.

TL;DR: The current disease-relevant knowledge for isoform-specific PI3K function in the above mentioned diseases is reviewed, and the progress of >400 recent patents covering pharmaceutical targeting ofPI3K is reviewed.

TL;DR: In this paper, the redox control networks of eukaryotic cells have been investigated and further elucidation of these networks within compartments will improve the mechanistic understanding of cell functions and their disruption in disease.

TL;DR: NF-kappaB p65 subunit repressed the Nrf2-antioxidant response element (ARE) pathway at transcriptional level and might provide a new insight into a possible role of NF- kappaB in suppressing the expression of anti-inflammatory or anti-tumor genes.

TL;DR: Different from some more specialised short reviews, here a general although not encyclopaedic survey of the function, metabolic role, structure and mechanism of the ADP/ATP transport in mitochondria is presented.

TL;DR: The structure, composition and function of desmosomes are considered, and their role in embryonic development and disease is considered.

TL;DR: Overexpression of the drug efflux pump MDR-1/P-gp, altered expression of microtubule-associated proteins (MAPs) including tau, stathmin and MAP4 may help to identify those patients who are most at risk of recurrence and those patients most likely to benefit from taxane treatment.

TL;DR: In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane: the general Secretion route and the Twin-arginine translocation pathway, which catalyses the translocation of secretory proteins in their folded state.

TL;DR: It is found that peptide aggregation, either prior or after binding to the membrane surface, is a prerequisite to pore formation, and transmembrane pores spontaneously form above a critical peptide to lipid ratio.

TL;DR: Examination of the current three-dimensional structures of the outer membrane receptors, PBPs, and ABC transporters provides an overview of the structural biology of iron uptake in bacteria.

TL;DR: An overview of recent progress in studies on transmembrane proteins of tight junctions, claudins, junctional adhesion molecules, occludin and tricellulin is provided to highlight their roles and regulation, as well as their functional significance in human diseases.

TL;DR: A better understanding of the biophysical properties of functional and dysfunctional PS is important for the further development of surfactant therapy, especially for its potential application in ARDS.

TL;DR: This review focuses on redox control of cell function by MAP kinase signaling, and provides the advanced mechanism of redox-regulated ASK1 activation and physiological roles of theASK1-MAP kinase pathway in stress signaling.

TL;DR: This review focuses on apical polarity complexes, namely the PAR3/PAR6/aPKC complex and the CRUMBS/PALS1/PATJ complex, which are crucial to the formation of apical junctions such as tight junctions in mammalian epithelial cells.

TL;DR: The background to the development of mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death and also to develop probes of mitochondrial function are outlined.

TL;DR: The limitations in structural complexity and biophysical performance of surfactant preparations reconstituted in vitro will be highlighted in particular, to allow for a proper evaluation of the significance of the experimental model systems used so far to study structure-function relationships in surfactants.

TL;DR: In this paper, the authors show that the activity of Yap1 is itself controlled depending on the redox state of some of its cysteine residues, which determines the nucleocytoplasmic location of the Yap 1 molecules.

TL;DR: A model in which morphogenesis of the rod-shaped E. coli is driven by cytoskeleton elements competing for the control over the murein synthesis multi-enzyme complexes is presented.

TL;DR: This review of junctional complexes related to those found at epithelial junctions but with notable changes in terms of specific molecules and organization is reviewed.

TL;DR: This review will focus on the present understanding of the different roles played by these kinases, their regulation throughout cell division, their deregulation in human cancers and on the progress that is made in targeting these important regulators in the treatment of cancer.

TL;DR: The main strategies that are currently in use or likely to be employed in the near future to associate both targeting and delivery properties are described.

TL;DR: It is revealed that one PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a novel LPA receptor called P2Y5.

TL;DR: The diversity of cellular functions described for the human PDIs is explored, which emphasizes as much their differences as their similarities, and underlines the versatility of the thioredoxin fold.