Showing papers in "Biochimica et Biophysica Acta in 2011"

TL;DR: It turns out that regenerative or anti-inflammatory activities of interleukin-6 are mediated by classic signaling whereas pro-inflammatory responses of interLEukin -6 are rather mediated by trans-signaling.

TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.

TL;DR: The structural parameters of fluid phase bilayers composed of phosphatidylcholines with fully saturated, mixed, and branched fatty acid chains, at several temperatures, have been determined by simultaneously analyzing small-angle neutron and X-ray scattering data to assess the effect of temperature and hydrocarbon chain composition on bilayer structure.

TL;DR: Current understanding of mechanisms by which Akt and FoxOs regulate cell growth and survival that in turn offers opportunities for development of novel strategies to combat cancer is summarized.

TL;DR: The nuclear translocation of signaling components may emerge as an important regulatory layer in the induction of cellular processes, and therefore, may serve as targets for therapeutic intervention in signaling-related diseases such as cancer and diabetes.

TL;DR: Understanding is summarized on how transcription factors/receptors connect lipid metabolism to inflammation and some of the novel regulatory mechanisms by which they contribute to homeostasis and certain pathological conditions.

TL;DR: The present review summarizes the current knowledge of FoxO regulation by AKT and 14-3-3 proteins, focusing on its mechanistic and structural aspects and discusses its crosstalk with the other FoxO regulatory mechanisms.

TL;DR: This review updates structural information of chlorophyll catabolites and the biochemical reactions involved in their formation, and discusses the significance ofchlorophyll breakdown.

TL;DR: This work discusses the different strategies that are used to prevent cell death and illustrates that although anti-apoptosis and cellular survival serve to counteract PCD, they are nevertheless mechanistically distinct from the processes that regulate cell death.

TL;DR: These issues emphasise the amazing power of surfactants to both extend the protein conformational landscape and at the same time provide convenient and reversible short-cuts between the native and denatured state for otherwise obdurate membrane proteins.

TL;DR: An overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells are provided.

TL;DR: An introduction to NMR-based approaches for studying protein dynamics is provided, highlighting eight distinct methods with recent examples, contextualized within a common experimental and analytical framework.

TL;DR: How Bax and Bak change conformation and oligomerize, as well as how oligomers might form a pore is reviewed, which indicates that they first form symmetric BH3:groove dimers which can be linked via an interface between the α6-helices to form high order oligomers.

TL;DR: This remarkable account of Peter Mitchell's ideas originally published in 1966 is a landmark and must-read publication for any scientist in the field of bioenergetics.

TL;DR: Understanding the unique characteristics of engineered nanomaterials and their interactions with biological systems is key to the safe implementation of these materials in novel biomedical diagnostics and therapeutics.

TL;DR: This review article puts emphasis on the description of various bioenergetic types of tumors, from exclusively glycolytic to mainly OXPHOS, and the modulation of both the metabolic apparatus and the modalities of energy substrate utilization according to tumor stage, serial oncogene activation and associated or not fluctuating microenvironmental substrate conditions.

TL;DR: This paper will review common metabolic properties of the fermenting yeast Saccharomyces cerevisiae and tumor cells as well as the possible origins of the Crabtree and Warburg effects.

TL;DR: A number of recent developments by the LIPID MAPS bioinformatics core in pursuit of the detection, quantitation and pathway reconstruction of lipids and related genes and proteins at a systems-biology level are discussed.

TL;DR: Current knowledge on the physiological functions, genetics, structural and catalytic properties of cytochromes bd, a respiratory quinol: O₂ oxidoreductase found in many prokaryotes, is summarized.

TL;DR: This review deals with the events that enable cell death in type II cells, i.e., the signals that lead from death receptor stimulation to permeabilisation of the outer mitochondrial membrane, and discusses the determinants of the type I-type II cell distinction.

TL;DR: HIF-1-dependent regulation of mitochondrial metabolism may also contribute to the protective effects of ischemic preconditioning.

TL;DR: It is reported that human glioblastoma SF188 cells oxidize fatty acids and that inhibition of fatty acid β-oxidation by etomoxir, a carnitine palmitoyltransferase 1 inhibitor, markedly reduces cellular ATP levels and viability, providing evidence that mitochondrial fatty acid oxidation may provide NADPH for defense against oxidative stress and prevent ATP loss and cell death.

TL;DR: It seems evident that targeting adenosine receptors might indeed constitute a novel strategy to control the demise of different neurological and psychiatric disorders.

TL;DR: The concepts of coupling in secondary transport are summarized and discussed in the context of the available evidence for ion binding to specific sites and the impact of the ions on the conformational state of the carrier protein, which together lead to mechanistic models for coupling.

TL;DR: In this paper, the authors review the current understanding of the molecular determinants of the specificity of nuclear import, focusing on the importin-α•cargo recognition, as well as the currently available databases and predictive tools relevant to nuclear localization.

TL;DR: Medicinal chemical approaches have been applied to all four of the adenosine receptor (AR) subtypes to create selective agonists and antagonists for each to facilitate research on therapeutic applications of modulating the ARs and in some cases has provided clinical candidates.

TL;DR: The control of cell proliferation by microRNAs (miRNAs) is well established and the alteration of these small, non-coding RNAs may contribute to tumor development by perturbing critical cell cycle regulators.

TL;DR: This review will describe the mechanistic bases and rationale for the use of pharmacological agents that modify energy substrate metabolism to improve cardiac function in the ischemic and failing heart.

TL;DR: Emerging evidence indicates that the interaction of BH3-only proteins with membranes regulates binding to other Bcl-2 family members, thereby specifying function.

TL;DR: An overview of genetics, clinical and molecular progress recently performed in understanding the basis of HPGL/PCC tumorigenesis is reported.