Showing papers in "Biochimica et Biophysica Acta in 2013"

TL;DR: This review traces natural products drug discovery, outlining important drugs from natural sources that revolutionized treatment of serious diseases and effective drug development depends on multidisciplinary collaborations.

TL;DR: Recent advances in understanding the diversity of molecular mechanisms that govern ER stress signaling in health and disease are summarized.

TL;DR: The recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy is reviewed, focusing on the relevance and impact of this crosstalk in normal development and in pathology.

TL;DR: Cancer cells develop anoikis resistance due to several mechanisms, including change in integrins' repertoire allowing them to grow in different niches, activation of a plethora of inside-out pro-survival signals as well as leading to metabolic deregulations of cancer cells.

TL;DR: This comprehensive review summarizes fundamental principles of glutathione catalysis and compares the structures and mechanisms ofglutathione-dependent enzymes, including glutathion reductase, glutaredoxins, glutATHione peroxidases, peroxiredoxinases, glyoxalases 1 and 2, glutthione transferases and MAPEG.

TL;DR: The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications will be discussed.

TL;DR: Four flavin-containing cytoplasmatic multienzyme complexes from anaerobic bacteria and archaea that catalyze the reduction of the low potential ferredoxin by electron donors with higher potentials at ≤ 100 kPa are described.

TL;DR: The present review is focused on the chemistry of NAC and its interactions and functions at the organ, tissue and cellular levels in an attempt to bridge the gap between its recognized biological activities and chemistry.

TL;DR: Given that adipocytes are a major source of adipokines and energy for the cancer cell, understanding the mechanisms of metabolic symbiosis between cancer cells and adipocytes, should reveal new therapeutic possibilities.

TL;DR: The detailed lipid composition provided in this study may be useful to understand the mechanism of exosome formation, release and function, and several of the lipids enriched in exosomes could potentially be used as cancer biomarkers.

TL;DR: This article summarizes the current knowledge of the N-glycosylation pathway in the ER that results in the covalent attachment of an oligosaccharide to asparagine residues of polypeptide chains and focuses on the model organism Saccharomyces cerevisiae.

TL;DR: Targeted disruption of each PS synthase individually in mice demonstrated that neither enzyme is required for viability whereas elimination of both synthases was embryonic lethal, indicating that mammalian cells require a threshold amount of PS.

TL;DR: In this review, some key biophysical features of IDPs are covered and it is proposed that the heterogeneous spatiotemporal structure of IDP/IDPRs can be described as a set of foldons, inducible foldon, semi-foldons, non-foldon, and unfoldons.

TL;DR: Current knowledge regarding the regulation and physiologic relevance of Drp1-dependent mitochondrial fission is reviewed: the initial recruitment and assembly ofDrp1 on the mitochondria fission foci, regulation of Dr p1 activity by post-translational modifications, and the role of mitochondrial fissions in cell pathophysiology are reviewed.

TL;DR: These exciting findings demonstrate that the physiological interactions between the ER and mitochondria are so bilateral that the relationship is tempted to compare their relationship to the one of a married couple: distinct, but inseparable and certainly dependent on each other.

TL;DR: This review will focus on the common organizing principles underlying the many MCSs found between the ER and virtually all compartments of the cell, and on how the ER establishes a network of M CSs for the trafficking of vital metabolites and information.

TL;DR: Novel insights into the molecular basis of ROS-induced pulmonary diseases and, in particular, lung epithelial cell death may promote the development of unique therapeutic targets for managing pulmonary fibrosis as well as fibrosis in other organs and tumors, and in aging.

TL;DR: A global and integrated overview of the signaling networks that may determine the elimination of a cell under chronic ER stress is provided and the participation of the BCL-2 family of proteins and ER calcium release is highlighted.

TL;DR: This work focuses on recent advances in the study of enzymatic regulatory pathways for CS biosynthesis including successive modification/degradation, distinct CS functions, and disease phenotypes that have been revealed by perturbation of the respective enzymes in vitro and in vivo.

TL;DR: The manipulation of the albumin-FcRn interaction will facilitate the modulation of the circulatory half-life ofalbumin-enabled drugs, leading to superior pharmacokinetics tailored to the disease state and increased patient compliance.

TL;DR: It was found that GLUT1 overexpression is associated with poor overall survival in various malignant tumors and has been found to be associated with tumor progression.

TL;DR: The thorough understanding of metal binding properties of serum albumin, including the competition of various metal ions for specific binding sites is important for biomedical issues, such as new disease markers and design of metal-based drugs.

TL;DR: An overview of the current concept of cornification as a mode of programmed cell death and the anti-cell death mechanisms in the epidermis that secure epidermal homeostasis is given.

TL;DR: Together, macrophages contribute to tissue fibrosis because the changing tissue environments prime them to assist and orchestrate all phases of tissue injury and repair.

TL;DR: This review focuses on one of the best characterized ARE binding proteins, tristetraprolin (TTP), the founding member of a small family of CCCH tandem zinc finger proteins, and discusses emerging evidence for TTP operating as a translational regulator.

TL;DR: The present review discusses recent findings regarding the nature of drug binding sites, drug-albumin binding in certain diseased states or in the presence of co administered drugs, and the potential of utilizing albumin-drug interactions in clinical applications.

TL;DR: Given the potential for one pannexin to compensate for another it seems imperative to generate single and double knockout mouse models involving all three pannexins and evaluate their interplay in normal differentiation and development as well as in malignant transformation and disease.

TL;DR: Rab7 is an effective multifunctional regulator of autophagy and endocytosis, and might hold potential as a therapeutic target against age-related macular degeneration of the eye and Alzheimer's disease.

TL;DR: Human cytosolic GSTs have emerged as significant regulators of pathways determining cell proliferation and survival and as regulators of ryanodine receptors that are essential for muscle function.

TL;DR: The present status of DFT studies on water oxidation in photosystem II is described and it is argued that a full understanding of all steps is close.