Showing papers in "Biochimica et Biophysica Acta in 2020"

TL;DR: The analysis suggests a minimal variation in the genome sequence of SARS-CoV-2, may be responsible for a drastic change in the structures of target proteins, makes available drugs ineffective.

TL;DR: This review presents some of the problems and current treatment options contributing to the poor outcomes for patients with liver cancer and suggests use of natural compounds and/or nanotechnology may provide patients with better outcomes with lower systemic toxicity and fewer side effects.

TL;DR: This review discusses the reciprocal interplay between tumor cells, cancer associated fibroblasts (CAF), immune cells and ECM stiffness in malignant transformation and cancer aggression, and discusses emerging anti-fibrotic strategies aimed at treating cancer.

TL;DR: The risk factors associated with isChemic stroke, changes in cell morphology and signaling in the brain after stroke, and the advantages and disadvantages of in vivo and in vitro ischemic stroke models are examined.

TL;DR: An overview of public repositories where non-coding RNA-regulatory interactions are collected and annotated is presented, unresolved questions for data integration are discussed and existing resources to build and analyse networks are recalled.

TL;DR: The challenges, as well as the emergence of new technologies that will continue to move this field forward and provide greater insight into the biological importance of this class of genes are discussed.

TL;DR: The present review summarizes the current understanding of the GSK3-β neurobiology with particular emphasis on its effects on specific signaling pathways associated with AD pathophysiology and provides a summary of the current research effort to develop GSK 3-β inhibitors in preclinical and clinical studies.

TL;DR: Both sources and consequences of mitochondrial ROS during IR and in the chronic setting following MI are discussed, thereby emphasizing the potential therapeutic value of attenuating mitochondrial ROS to improve outcome and prognosis for patients suffering MI.

TL;DR: This review highlights the exercise-induced anti-inflammatory effect on the prevention or treatment of common chronic clinical and experimental settings and suggests the use of pterins in biological fluids as sensitive biomarkers to follow the anti- inflammatory effect of physical exercise.

TL;DR: The roles of caspases as safeguards against cancer in the context of the advantages and potential limitations of targeting apoptotic caspasing for the treatment of cancer are discussed.

TL;DR: This review focuses on the mechanism of oxidative stress in pregnancy as well as its involvement and consequences on the human pregnancy-specific clinical syndrome preeclampsia.

TL;DR: The roles of cholesterol and its metabolites, and the latest advances in cancer therapy targeting cholesterol metabolism are reviewed.

TL;DR: The S100 target protein interactions that underpin the mechanistic basis to their function are detailed, and potential intervention strategies targeting S100 proteins in both preclinical and clinical situations are discussed.

TL;DR: Overall, blue light may promote the accumulation of phenylpropanoid-based compounds without substantially affecting plant morpho-anatomical traits compared to the effects of white light, while red light, conversely, strongly alters plant morphology and physiology compared to that under white light without showing a consistent positive effect on secondary metabolism.

TL;DR: The current review discusses the potential role and molecular mechanism of lncRNA in regulating the prominent hallmarks of cancer including abnormal growth, survival, metastasis, and drug-resistance in PDAC and highlights the possible application of various therapeutic strategies.

TL;DR: Role of mitochondria in the pathogenesis of metabolic syndrome is intriguing but far from completely understood; a better understanding will be very rewarding as it may lead to novel approaches to control these major public health problems.

TL;DR: This review focuses on the molecular mechanism of GSK-3β in DNA repair, special in base excision repair and double-strands break repair, the roles of G SK-3 β in inhibition of apoptosis through activation of NF-κB, and the effects of Gsk- 3β inhibitors on radio- and chemosensitization of various types of cancers.

TL;DR: Recent data demonstrating the role of cell cycle regulators in the metabolic control especially in studies performed in cancer models are described to provide an overview of the relevance of targeting metabolism using inhibitors of the cell cycle regulation.

TL;DR: The present narrative review will describe the current view of mitochondria in regulation of immune responses, and discuss the current knowledge on disturbed mitochondrial function in immune cells in various immunological diseases.

TL;DR: Current knowledge of metabolism and functions of fucoxanthin with its potential health benefits is reviewed, which shows a strong antioxidant capacity by scavenging singlet molecular oxygen and free radicals.

TL;DR: An up-to-date overview on the main biochemical features and biotechnological applications of those reported enzymes which are able to degrade polyester-based plastics, including different microbial polyester depolymerases, esterases, cutinase-like enzymes and lipases.

TL;DR: Current literature interrogating the mechanisms by which diets high in fat, or fat and sugar lead to cognitive impairment, focusing on changes to gut microbiome composition, inflammatory signalling and blood-brain barrier integrity suggests weight gain is not necessary for diet-induced cognitive impairment.

TL;DR: Data from these studies suggest that several carotenoids might provide a beneficial impact on reducing carcinogenesis, and further studies are needed to determine the causal relationships between individual carOTenoids and cancer incidence and progression.

TL;DR: This review integrates findings of cathepsin B regulation in clinical biomarker studies, animal model genetic and inhibitor evaluations, structural studies, and lysosomal cell biological mechanisms in AD, TBI, and related brain disorders to implicate cathePSin B as a major contributor to these neuropathological changes and behavioral deficits.

TL;DR: This review article summarizes possible targets of cancer cell stemness for the complete treatment of cancer.

TL;DR: This review provides some details about using AuNPs in sensing and catalysis applications as well as promising theranostic nanoplatforms for cancer imaging and diagnosis, and sensitive, non-invasive, and synergistic methods for cancer treatment in an almost comprehensive manner.

TL;DR: The notion that the non-apoptotic functions of Caspase-8 offer growth advantage in these cancer types and have, therefore, gained renewed interest in the recent years supports the notion that pro-Casp enzyme expression is maintained and sometimes elevated, while it's apoptotic activity is regulated through different mechanisms.

TL;DR: A comprehensive benchmark study exploiting two state-of-the-art footprint methods, DoRothEA and an extended version of PROGENy, shows that both can recover mouse perturbations, confirming the hypothesis that footprints are conserved between mice and humans.

TL;DR: This review revisit the recent mechanistic insights into the contributions of TME to the development, progression, prognosis prediction and therapeutic efficacy of ovarian cancer via modulating cancer hallmarks and explored potentially promising predictive and prognostic biomarkers for ovarian cancer patients.

TL;DR: There is a rising interest in octamer-binding transcription factor 4 (OCT4), one of the stem cell factors that are essential in embryogenesis and pluripotency, which is also overexpressed in CSCs of various cancers.