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Showing papers in "Biological Psychiatry in 2022"


Journal ArticleDOI
TL;DR: In this article , the authors conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC).

75 citations


Journal ArticleDOI
TL;DR: A review of the evidence for TBI as a risk factor for neurodegenerative disorders, including Alzheimer's dementia and Parkinson's disease, in clinical and neuropathological studies is presented in this paper .

53 citations


Journal ArticleDOI
TL;DR: In this paper, the impact of sex chromosomes and sex hormones on Alzheimer's disease (AD) and the interplay between sex and a major AD genetic risk factor, the APOE e4 genotype, through the multiomics landscape.

40 citations


Journal ArticleDOI
iPSYCH1
TL;DR: In this article, a genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10-8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability.

36 citations


Journal ArticleDOI
TL;DR: In this paper , the impact of sex chromosomes and sex hormones on Alzheimer's disease was discussed, and the interplay between sex and a major AD genetic risk factor, the APOE ε4 genotype, through the multiomics landscape.

34 citations


Journal ArticleDOI
TL;DR: In this paper , the authors report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation.

33 citations


Journal ArticleDOI
TL;DR: In this article , the authors conducted the largest-to-date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH.

33 citations


Journal ArticleDOI
TL;DR: In this paper , the authors used dynamic causal modeling to quantify synaptic connectivity in cortical microcircuits and found that pyramidal cells or interneurons are affected, or how these deficits relate to symptoms.

30 citations


Journal ArticleDOI
TL;DR: In this paper, a review of the well-known sex difference in incidence of major depressive disorder is presented, with women being twice as likely to be diagnosed as men, and briefly summarize how the impact of MDD varies between men and women, with sex differences in symptoms, severity, and antidepressant drug response.

28 citations


Journal ArticleDOI
TL;DR: In this article , the authors reviewed the well-known sex difference in incidence of major depressive disorder, with women being twice as likely to be diagnosed as men, and briefly summarized how the impact of MDD varies between men and women, with sex differences in symptoms, severity, and antidepressant drug response.

27 citations


Journal ArticleDOI
TL;DR: In this article , the authors investigated the efficacy and safety of lysergic acid diethylamide (LSD)-assisted therapy in patients who experienced anxiety with or without association with a life-threatening illness.

Journal ArticleDOI
TL;DR: The integrated neurodevelopmental and dopamine hypothesis suggests that overpruning of synapses, potentially including glutamatergic inputs onto frontal cortical interneurons, disrupts the cortical excitation-inhibition (E/I) balance and thus underlies cognitive and negative symptoms as discussed by the authors .

Journal ArticleDOI
TL;DR: A review of the epidemiology of psychiatric and neurobehavioral problems after traumatic brain injury in military, civilian, and athletic contexts can be found in this paper , with a focus on the cognitive, affective, and behavioral sequelae.

Journal ArticleDOI
TL;DR: Sex differences in nociceptor-enriched translatomes are demonstrated and unexpected sex differences in one of the oldest known nocICEptive signaling molecule families, the prostaglandins are revealed.

Journal ArticleDOI
TL;DR: In this paper , a large-scale transcriptome analysis of RNA sequencing data from 437 controls and 341 cases from two distinct cohorts from the CommonMind Consortium was performed to identify a reproducible gene expression signature of schizophrenia that was highly concordant with previous work.

Journal ArticleDOI
TL;DR: In this paper , the cellular and neural circuit mechanisms underlying ATP deficiency-induced depressive-like behavior were investigated using ex vivo slice electrophysiology, chemogenetic manipulations, RNA interference, gene knockout, behavioral testing, and two depression mouse models, one induced by chronic social defeat stress and one caused by a IP3R2-null mutation.

Journal ArticleDOI
TL;DR: For example, this paper found that male rodents subjected to adolescent social isolation (SI) stress form stronger preferences for drugs of abuse in adulthood, and that SI has region-specific effects on sex-specific transcriptional responses to cocaine and reduces sex differences in gene expression across all three brain regions.

Journal ArticleDOI
TL;DR: The endocannabinoid (eCB) system is one of the most ubiquitous signaling systems of the brain and offers a rich pharmacology including multiple druggable targets as mentioned in this paper .

Journal ArticleDOI
TL;DR: Recently, growing evidence supports significant involvement of immune dysfunction in the etiology of neurodegenerative diseases, several of which also display prominent sex differences across prevalence, pathology, and symptomology as discussed by the authors.

Journal ArticleDOI
TL;DR: In this article , the authors used translating ribosome affinity purification sequencing and behavioral pharmacology to test the hypothesis that in Nav1.8-positive neurons, most of which are nociceptors, translatomes would differ by sex.

Journal ArticleDOI
TL;DR: In this article , the authors developed and tested a novel system for quantifying six brain circuits reproducibly and at the individual patient level, implemented standardized circuit definitions relative to a healthy reference sample and algorithms to generate circuit clinical scores for the overall circuit and its constituent regions.

Journal ArticleDOI
TL;DR: Tyr mice model ADNP syndrome pathology as mentioned in this paper , a paralog of the most common ADNP mutation, and are treated with microtubule/autophagy-protective ADNP fragment NAPVSIPQ (NAP).

Journal ArticleDOI
TL;DR: In this article , the authors used deep repetitive transcranial magnetic stimulation (dTMS) to target circuitry associated with the pathophysiology of alcohol addiction, including the medial prefrontal and anterior cingulate cortices.

Journal ArticleDOI
TL;DR: In this paper , the authors analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in bipolar disorder and highlighted the importance of mania prevention in BD treatment.

Journal ArticleDOI
TL;DR: In this article , the authors found that increased heartbeat evoked potential (rsHEP) modulation in patients with frontotemporal dementia (bvFTD) was associated with decreased brain volume and connectivity of the allostatic-interoceptive network.

Journal ArticleDOI
TL;DR: In this paper , the role of circadian astrocyte function in the nucleus accumbens (NAc), a hub for reward regulation, or determined the importance of these rhythms for reward-related behavior was identified.

Journal ArticleDOI
Irene Kato1
TL;DR: Recently, growing evidence supports significant involvement of immune dysfunction in the etiology of neurodegenerative diseases, several of which also display prominent sex differences across prevalence, pathology, and symptomology as mentioned in this paper .

Journal ArticleDOI
TL;DR: In this paper , a simple solution that incorporates cohort-specific ascertainment using the summation of effective sample sizes across cohorts is proposed to recover liability-scale heritability in the population.

Journal ArticleDOI
noyogi79221
TL;DR: In this paper , the effect of allopregnanolone on the basolateral amygdala (BLA) was investigated and it was shown that allop-regnanoline enhances the BLA high theta oscillations through δ-containing GABAA receptors.

Journal ArticleDOI
TL;DR: The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the central nervous system and is involved intensively in modulating pain and stress-related disorders as mentioned in this paper .