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Showing papers in "Biomacromolecules in 2003"


Journal ArticleDOI
TL;DR: The current review of 129 references describes the biological activity of several chitosan derivatives and the modes of action that have been postulated in the literature.

2,615 citations


Journal ArticleDOI
TL;DR: This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field.

1,441 citations


Journal ArticleDOI
TL;DR: The quartz crystal microbalance technique is a simple, cost effective, high-resolution mass sensing technique, based upon the piezoelectric effect, which has witnessed an explosive growth in the application of the QCM technique to the study of a wide range of molecular systems at the solution-surface interface, in particular, biopolymer and biochemical systems.

1,077 citations


Journal ArticleDOI
TL;DR: The synthesis of novel hybrid hydrogels by stepwise copolymerization of multiarm vinyl sulfone-terminated poly(ethylene glycol) macromers and alpha-omega cysteine oligopeptides via Michael-type additions is described, and structure and properties are very sensitive to the preparation state including stoichiometry and precursor concentration and lesssensitive to the pH during cross-linking.

721 citations


Journal ArticleDOI
TL;DR: A strong similarity is seen between the behavior of this system and a colloidal gas-liquid phase separation, and a "metastable" region delimited by a percolation line is seen.

552 citations


Journal ArticleDOI
TL;DR: By manipulating the multilayer pH or ionic strength assembly conditions or both, which in turn dictate the molecular architecture of the thin films, one may powerfully direct a single multilayers combination to be either cell adhesive or cell resistant.

491 citations


Journal ArticleDOI
TL;DR: Comparatively, better resistance of evaporated samples than hot-pressed ones against swelling in an organic solvent medium is good resistance for the existence of a rigid chitin network, and the values of diffusion coefficient, bound rubber content, and relative weight loss supported the presence of a three-dimensional chit in network within the evaporate samples.

478 citations


Journal ArticleDOI
TL;DR: The aim of this paper is to define optimal conditions for the extraction of chitin from shrimp shells with kinetics of both demineralization and deproteinization with, in the latter case, the role of temperature studied.

404 citations


Journal ArticleDOI
TL;DR: Modelling of protein electrostatics via Delphi is used to visualize this effect for BSA, lysozyme, insulin, and beta-lactoglobulin, which appears to be a general effect caused by electrostatic repulsions that can coexist simultaneously with hydrophobic interactions.

398 citations


Journal ArticleDOI
TL;DR: The enhanced thromboresistance of the self-assembled multilayer together with the antiinflammatory and wound healing properties of hyaluronan and chitosan are expected to reduce the neointimal hyperplasia associated with stent implantation.

354 citations


Journal ArticleDOI
TL;DR: Various cellulose samples converted into cellulose III by two different ammonia treatments were reacted with catalytic amounts of 2,2,6,6-tetramethylpiperidine-1-oxyl radical, sodium hypochlorite, and sodium bromide in water and a relationship between oxidation conditions and cellulose primary hydroxyl groups accessibility was directly established.

Journal ArticleDOI
TL;DR: Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer, finding values of the refractive index increment, radius of gyration, second viral coefficient, and intrinsic viscosity are increasing.

Journal ArticleDOI
TL;DR: Results suggest that peptide-cross-linked P(NIPAAm-co-AAc) hydrogels can be tailored to create environmentally-responsive artificial extracellular matrixes that are degraded by proteases.

Journal ArticleDOI
TL;DR: Novel glucose-responsive polymers that operate under physiological conditions are developed, aiming for future use in a self-regulated insulin delivery system to treat diabetes mellitus, indicating that spacing of the phenylborate moiety from the polymer backbone is a feasible way to minimize the microenvironment effect caused by a temperature-induced change in the hydration state of the polymer strands.

Journal ArticleDOI
TL;DR: The cellulose fibers modified by reacting the hydroxyl groups on the fiber surface with 2-bromoisobutyryl bromide, followed by grafting using ATRP conditions go to show that the hydrophilic/hydrophobic behavior of a cellulose surface can be tailored by the use of "living"/controlled radical polymerization methods such as ATRP.

Journal ArticleDOI
TL;DR: Despite a variety of shapes, characteristic geometrical features of the nanocrystalsa were recognized, such as marked 60-65 degrees acute angles and constituting parallelepipedal blocks with a length of 20-40 nm and a width of 15-30 nm.

Journal ArticleDOI
TL;DR: In this paper, degradable hydrogels were used to tune the degradation profiles of polymer cell carriers to match cell and tissue growth, which is an important design parameter for (cartilage) tissue engineering.

Journal ArticleDOI
TL;DR: It is concluded that this loss of performance is due to the partial destruction of the three-dimensional network of chitin whiskers assumed to be present in the unmodified composites.

Journal ArticleDOI
TL;DR: It appears that in the case of the graft copolymer the improvement in the properties comes from suppression of the crystallinity of each component and not from component interactions, and blending may be a more efficient way to improve ductility of chitosan.

Journal ArticleDOI
TL;DR: Electrospun poly(glycolide-co-lactide) biodegradable nanofiber membranes possessed very high surface area to volume ratios and were completely noncrystalline with a relatively lowered glass transition temperature, which led to very different structure, morphology, and property changes during in vitro degradation, which were examined systematically.

Journal ArticleDOI
TL;DR: Swelling experiments indicate hydrogel mass decreases by 80-90% gradually over an approximate 50 degrees C temperature range, and changes in gel stiffness and loss angle with cross-linking formulation suggest a low-temperature gel structure that is nearly completely elastic, and a high-tem temperature gel structure, where ELP chains are contracted and force is transmitted through chemical cross-links as well as frictional contact between polypeptide chains.

Journal ArticleDOI
TL;DR: Kinetic studies indicate that the copolymerization is well controlled with molecular weights increasing linearly with conversion and the thermosensitivity and aggregation properties of the random, gradient, and block copolymers significantly depended on the architecture of theCopolymers.

Journal ArticleDOI
TL;DR: It is demonstrated that these options permit control of the physicochemical constraints for bioactive molecules immobilized at interfaces to influence important performance characteristics of biofunctionalized materials for medical devices and molecular diagnostics.

Journal ArticleDOI
TL;DR: It is demonstrated that knowledge of the acid-base dissociation behavior in multilayer films is key to understanding and controlling the physical properties of the films, particularly surface friction and wettability, which are fundamentally important factors for many biomaterials applications.

Journal ArticleDOI
TL;DR: Stability of the immobilized enzyme has been found to be much higher using the new support than in preparations using the conventional ones in many cases, and immobilization is much more rapid using amino-epoxy supports than employing conventional epoxy supports.

Journal ArticleDOI
TL;DR: The facile preparation of a range of novel, well-defined cyclic sugar methacrylate-based polymers without recourse to protecting group chemistry is reported.

Journal ArticleDOI
TL;DR: Although the PVA/lignin blend system is immiscible in the bulk, the results herein show the existence of some specific intermolecular interaction between PVA and lignin.

Journal ArticleDOI
TL;DR: The experimental results show that the nanostructures formed by the peptides are dependent on the amino acid sequence and the pH of the solution, indicating that the formation of globular assemblies is related to the molecular hydrophobicity.

Journal ArticleDOI
TL;DR: Methacrylate-mediated photo-cross-linking is a facile route to improve mechanical properties of collagen gels in the presence of cells while maintaining high cell viability, which enhances the potential for type I collagen gelt to be used as scaffolds for tissue engineering.

Journal ArticleDOI
TL;DR: The results emanating from the successive tensile test experiments give clear evidence for the presence of a three-dimensional chitin network within the evaporated samples, and cross-linking of the matrix was found to interfere with the formation of this network.