scispace - formally typeset
Search or ask a question

Showing papers in "Biomaterials in 1993"


Journal ArticleDOI
TL;DR: Recent discoveries that organs and tissues can be regenerated and reconstructed, using cells cultured on synthetic biodegradable polymers, renders this method useful in creating polymer-cell graft for use in cell transplantation.

694 citations


Journal ArticleDOI
TL;DR: The tetrazolium-based colorimetric assay (MTT test) was confirmed to be feasible, rapid and reproducible and showed a good correlation with other in vitro proliferation assays, such as the 3H-thymidine uptake assay.

407 citations


Journal ArticleDOI
TL;DR: Cl clotting times and haemolytic index values were intermediate between the values observed for Teflon and Silastic controls, indicating that polyimide materials are good candidates for further testing as encapsulants for implantable biosensors.

304 citations


Journal ArticleDOI
TL;DR: It is shown that, similar to natural macromolecules of the extracellular matrix, the synthetic polymers are able to participate in the control of cell function.

275 citations


Journal ArticleDOI
TL;DR: The pore size and the in vivo behaviour of four poly(2-hydroxyethyl methacrylate) sponges were investigated and it was showed that the cut polymer surfaces allowed a greater cellular invasion than the moulded ones.

251 citations


Journal ArticleDOI
TL;DR: Hydrogels were created by electron beam irradiation of aqueous solutions of poly(ethylene oxide) (PEO) having a nominal molecular weight of 35,000 and related to the hydrogel parameters Mc and v2,s and to the solute effective radius rE (Einstein radius).

246 citations


Journal ArticleDOI
TL;DR: Three poly(L-lactides) with different molecular weights were synthesized and implanted into the dorsal muscle of rats, forming a collagenous fibrous layer that seems to meet the requirements for an absorbable material for osteosynthesis.

218 citations


Journal ArticleDOI
TL;DR: Both of the functional groups introduced onto the polyethylene surface were found to be utilizable for covalent immobilization of protein using carbodiimide for the carboxylic group or mediators such as glutaraldehyde and ethylene glycol diglycidyl ether for the amino group.

212 citations


Journal ArticleDOI
TL;DR: In the present study both the biocompatibility and biodegradation of some water-insoluble HL esters have been evaluated, either as raw material or as manufactured devices after subcutaneous and intraperitoneal implantation in male rats.

211 citations


Journal ArticleDOI
TL;DR: Three poly(L-lactides) with different molecular weights were synthesized as solid blocks from the melt, and implanted as small rods into the dorsal muscle of rats, showing differences depending on the solid state of the polymer.

194 citations


Journal ArticleDOI
TL;DR: The contraction measurements were carried out with a linometer, a simple device to determine true linear polymerization contraction of liquid monomers at ambient temperature and the estimated conversion of the BisGMA-TEGDMA, calculated using the contraction, is consistent with literature values.

Journal ArticleDOI
TL;DR: The biodegradation and tissue reaction of the copolymer poly(D,L-lactide-co-glycolide) microspheres prepared by the solvent evaporation method, radiosterilized and stereotactically implanted in the rat brain were studied and may be considered biocompatible to the brain tissue.

Journal ArticleDOI
TL;DR: The results suggest that nanoparticles designed for use as injectable drugs or drug carriers should display similar surface characteristics provided by such amphiphilic surface modifiers.

Journal ArticleDOI
TL;DR: Careful choice of technique and polymerization conditions enables macroporous hydrogels with a wide range of morphologies to be fabricated, which are potentially valuable in a variety of biomedical applications.

Journal ArticleDOI
TL;DR: The data indicate that hydroxyl radical is likely to be a major factor in the degradation of this polymer, and this semicrystalline physiologically absorbable polymer was used as the control in a study of the effects ofhydroxyl radicals in aqueous solutions.

Journal ArticleDOI
TL;DR: To measure the effect of the calcium phosphate content of the ceramic on its osseointegration, macroporous ceramics, differing in their chemical composition, were implanted into sheep femurs and showed significant differences in the amount of bone formed at the contact of the different Ceramics.

Journal ArticleDOI
TL;DR: A previous study of coralline hydroxyapatite as a bone-graft substitute was extended from 4 to 12 months to determine better the relationships between implantation time, bone ingrowth and mechanical properties.

Journal ArticleDOI
TL;DR: Surgical wounds from wisdom tooth avulsions were medicated with freeze-dried methylpyrrolidinone chitosan, a gel-forming resorbable biopolymer obtained from crab chitOSan by chemical modification, which promoted osteoconduction and the space left after avulsion was filled with newly formed bone tissue, which conferred desirable mechanical and physiological characteristics to the healed would site.

Journal ArticleDOI
TL;DR: An interpretation of the drug release from monolithic water-swellable and soluble polymer tablets is presented, and a convenient parameter, alpha, which compares the drug-diffusive conductance in the gel layer with the swelling and dissolving characteristics of the unpenetrated polymer was used to describe the release behaviour.

Journal ArticleDOI
TL;DR: The biocompatibility of microcapsules made by the co-acervation of alginate and poly(l-lysine) (PLL) was enhanced by coating the surface of these micro Capsules with a PEG-based hydrogel, which was found to be less inflammatory and to elicit a fibrotic response.

Journal ArticleDOI
TL;DR: The results clearly demonstrate that not only are osteoclasts capable of resorbing sintered hydroxyapatite but that the rugosity of the hydroxyAPatite influences the fusion of osteoclast mononuclear precursors.

Journal ArticleDOI
TL;DR: This review describes the synthesis and physico-chemical properties of reactive and labelled microspheres useful for biomedical applications.

Journal ArticleDOI
TL;DR: From scanning electron microscopic studies, it appears that the drug forms a crystal structure within the chitosan beads, which dissolves out slowly to the dissolution medium through the micropores of the ch itosan matrix.

Journal ArticleDOI
TL;DR: It is shown that the apparent insignificance of strict calcium:phosphorus ratio with respect to the biological results greatly simplifies processing of calcium phosphate ceramics for clinical application.

Journal ArticleDOI
TL;DR: The interaction between bovine atelocollagen and a high molecular weight fully deacetylated chitosan has been studied, and although the interaction is weak and hindered by gel formation in collagen solutions, a polyanion-polycation complex is obtained.

Journal ArticleDOI
TL;DR: The ultrastructural examination evidenced that bone osteoid was followed by mineralization of the tissue and the cationic nature and the chelating ability of the methylpyrrolidinone chitosan apparently favoured mineralization.

Journal ArticleDOI
TL;DR: The water contact angle of the PMMA film was markedly decreased by oxygen plasma treatment, AA grafting or protein immobilization, indicating the increase of hydrophilicity of the surface-modified PMMA films.

Journal ArticleDOI
TL;DR: An osteogenic cell line was used to study the potential of bioerodible polymers and ceramics to support osteoblast growth for a proposed bone-polymer composite for skeletal tissue repair, and high alkaline phosphatase activity for the cells grown on poly(lactide-co-glycolide) and hydroxyapatite/poly(lactoride- co-gly colide) confirmed retention of the osteoblost phenotype.

Journal ArticleDOI
TL;DR: It is concluded that sol-gel prepared silica is an efficient apatite inducer and the morphology of the hydroxyapatite deposit is determined by factors of the fluid such as pH, Ca/P molar ratio, Mg and F concentrations.

Journal ArticleDOI
TL;DR: Three factors were suggested to explain why the microcracks seem to prefer to grow in the interbead matrix: the presence of BaSO4, shrinkage during the curing process, and the different polymerization processes of the bead and the interBead polymers.