Showing papers in "Biomaterials in 2005"

TL;DR: This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications.

TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.

TL;DR: There is a strong rationale that in this research model, high magnesium ion concentration could lead to bone cell activation, and metallic implants made of magnesium alloys degrade in vivo depending on the composition of the alloying elements.

TL;DR: The aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering after being evaluated in vitro using neural stem cells as a model cell line.

TL;DR: The ability to manipulate and reconstitute tissue structure and function using chitosan has tremendous clinical implications and is likely to play a key role in cell and gene therapies in coming years.

TL;DR: The integration of scaffold computational design and free-form fabrication techniques presented here could prove highly useful for the construction of scaffolds that have anatomy specific exterior architecture derived from patient CT or MRI data and an interior porous architecturederived from computational design optimization.

TL;DR: It is highly feasible for nanoparticles of biodegradable polymers to be applied to promote oral chemotherapy by using Caco-2 cells, showing that surface modification of PLGA nanoparticles with vitamin E TPGS notably improved the cellular uptake.

TL;DR: The PHA prospective will look very bright in the near future, according to this paper's review of what have been achieved in the PHA tissue engineering area and the changing PHA compositions.

TL;DR: The strong correlation between the scaffoldspecific surface area and cell attachment indicates that cell attachment and viability are primarily influenced by scaffold specific surface area over this range (95.9-150.5 microm) of pore sizes for MC3T3 cells.

TL;DR: The computer-aided inkjet printing of viable mammalian cells holds potential for creating living tissue analogs, and may eventually lead to the construction of engineered human organs.

TL;DR: The results indicate that unmodified BC supports chondrocyte proliferation at levels of approximately 50% of the collagen type II substrate while providing significant advantages in terms of mechanical properties, and suggest the potential for this biomaterial as a scaffold for tissue engineering of cartilage.

TL;DR: The findings reported here suggest that the PCL NFS is a practical carrier for MSC transplantation, and represents a candidate scaffold for cell-based tissue engineering approaches to cartilage repair.

TL;DR: Coacervation of chitosan and alginate combined with liquid-solid separation provides a scaffold with high porosity, and mechanical and biological properties suitable for rapid advancement into clinical trials.

TL;DR: These new silk-based three-dimensional matrices provide useful properties as biomaterial matrices due to the all-aqueous mode of preparation, control of pore size, connectivity of pores, degradability and useful mechanical features.

TL;DR: Experimental results from cell stain assay and SEM imaging showed that the nanofibrous structure promoted the attachment of human osteoblasts and chondrocytes and maintained characteristic cell morphology and viability throughout the period of study.

TL;DR: Only chitosan of a molecular weight of 106,000 g/mol produced bead-free chitOSan nanofibers, while low- or high-molecular-weight ch itosans of 30,000 and 398,000g/mol did not.

TL;DR: The hydrogel was found to have a fluid uptake of 90% of its weight which would prevent the wound bed from accumulation of exudates and can maintain a moist environment over wound bed in moderate to heavily exuding wound which would enhance epithelial cell migration during the healing process.

TL;DR: The photoinitiator Irgacure 2959 is well tolerated by many cell types over a range of mammalian species and cell photoencapsulation strategies may be optimized to improve cell survival by manipulating proliferation rate.

TL;DR: Cell culture studies confirmed that the electrospun engineered protein scaffolds support attachment and growth of human embryonic palatal mesenchymal (HEPM) cells.

TL;DR: To investigate the metal release of each base and alloying elements in vitro, SUS316L stainless steel, Co-Cr-Mo casting alloy, commercially pure Ti grade 2, and Ti-6Al-4V, V-free Ti- 6Al-7Nb and Ti

TL;DR: Biocompatibility studies of silk films (with or without covalently bound RGD) that were seeded with bone-marrow derived mesenchymal stem cells and cultured in vitro with human MSC suggest that purified degradable silk is biocompatible and the in vitro cell culture model gave inflammatory responses that were comparable to those observed in vivo.

TL;DR: In this paper, a model system of proteolytic degradation of silk fibroin yarns was created to create an in vitro model system for degradable biomaterials which can slowly and predictably transfer a loadbearing burden to developing biological tissue.

TL;DR: The composites are found to release Ag(+) at a concentration level capable of rendering an antimicrobial efficacy, found to be influenced by the SSA of the silver powder, changes in the physical state of the composite specimen as a result of the water diffusion and the composite morphology.

TL;DR: Smooth muscle cells were filtration seeded in the scaffolds and it was shown that both scaffolds supported cell adhesion and growth, with smooth muscle cells growing more extensively in the PEUU scaffold.

TL;DR: The current review will briefly survey the literature, which initially identified the problem of PU degradation in vivo and the subsequent studies that have led to the field's further understanding of the biological processes mediating the breakdown.

TL;DR: With the addition of an antioxidant, L-ascorbic acid, the oxidative damage and resultant toxicity of nano-C60 was completely prevented and damage to cell membranes was observed both with chemical assays, and confirmed physically by visualizing membrane permeability with high molecular weight dyes.

TL;DR: The aligned nanofiber scaffold used in this study constitutes a promising base material for tissue-engineered ligament in that it provides more preferable biomimetic structure, along with proper mechanical environment.

TL;DR: The polarization of microtubule organizing centers (MTOC) of SMC cultured on nanopatterned surfaces showed a preference towards the axis of cell alignment in an in vitro wound healing assay, which is proposed to provide a valuable platform for studies in cell-substrate interactions and for development of medical devices with nanoscale features.

TL;DR: The present results indicate that 2-4 mM Ca2+ is suitable for proliferation and survival of osteoblasts, whereas slightly higher concentrations (6-8 mM) favor osteoblast differentiation and matrix mineralization in both 2- and 3-dimensional cultures.

TL;DR: The preliminary experiments demonstrated the potential of the as-synthesized magnetite material in functional molecular imaging for biomedical research and clinical diagnosis by combining the advantage of MRI signal contrast, the non-polymer-coated surface chemistry for distinct bioconjugation and the homogenous nanometer size for better controlled biodistribution.