Showing papers in "Biomaterials in 2008"

TL;DR: This review summarizes the most recent and state of the art work in electrospinning and its uses in tissue engineering and drug delivery and its ability to fabricate fibers with diameters on the nanometer size scale.

TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.

TL;DR: It is demonstrated that tissue distribution of gold nanoparticles is size-dependent with the smallest 10nm nanoparticles showing the most widespread organ distribution.

TL;DR: The results of tensile tests and in vitro corrosion tests indicated that Mg-1Ca alloy had the acceptable biocompatibility as a new kind of biodegradable implant material and a solid alloy/liquid solution interface model was proposed to interpret the biocorrosion process and the associated hydroxyapatite mineralization.

TL;DR: PCL/gelatin 70:30 nanofiber was found to exhibit the most balanced properties to meet all the required specifications for nerve tissue and was used for in vitro culture of nerve stem cells and proved to be a promising biomaterial suitable for nerve regeneration.

TL;DR: Polyethyleneimine coated NaYF(4):Yb,Er nanoparticles were synthesized, which produce very strong upconversion fluorescence when excited at 980 nm by a NIR laser, and were shown to be stable in physiologic buffered saline (PBS), non-toxic to bone marrow stem cells, and resistant to photo-bleaching.

TL;DR: The goal of this review is to consider the role of nanoscale topographic modification of titanium substrates for the purpose of improving osseointegration and dental implant therapy.

TL;DR: X-ray photoelectron spectroscopy and UV-visible analyses of nanoceria treated with hydrogen peroxide demonstrate that a decrease in the Ce 3(+)/4(+) ratio correlates directly with a loss of SOD mimetic activity.

TL;DR: Accumulation of iron oxide nanoparticles in gliosarcomas can be significantly enhanced by magnetic targeting and successfully quantified by MR imaging, and these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery.

TL;DR: The aim of this review is to describe the "perfect vector" for systemic gene therapy against cancer based on the advantages and disadvantages of existing vectors and on the hurdles encountered with these carriers.

TL;DR: It is concluded that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery and leave behind no biohazardous sharp medical waste.

TL;DR: This study demonstrated for the first time, the application of polyphosphate as a hemostatic adjuvant, and developed a new chitosan-based composite with potent he mostatic and antimicrobial properties.

TL;DR: The results demonstrate that the in vivo behavior of the three-dimensional silk fibroin scaffolds is related to the morphological and structural features that resulted from different scaffold preparation processes.

TL;DR: Biological in vitro cell culture with human fetal osteoblast cells for up to 15 days demonstrated that the incorporation of HAp nanoparticles into chitosan nanofibrous scaffolds led to significant bone formation oriented outcomes compared to that of the pure electrospun CTS scaffolds.

TL;DR: It is indicated that cell infiltration can be expedited in dense fibrous assemblies with the removal of sacrificial fibers, and this strategy may enhance in vitro and in vivo formation and maturation of functional constructs for fibrous tissue engineering.

TL;DR: Metal electrode materials used in active implantable devices are often associated with poor long-term stimulation and recording performance and modification of these materials with conducting polymer coatings has been suggested as an approach for improving the neural tissue-electrode interface and increasing the effective lifetime of these implants.

TL;DR: Sonication provides a useful new tool with which to initiate rapid sol-gel transitions, such as for cell encapsulation, with high ionic strength and temperature and low pH responsible for increasing gelation kinetics.

TL;DR: The results show that unidirectionally oriented nan ofibers significantly induced muscle cell alignment and myotube formation as compared to randomly oriented nanofibers, suggesting that aligned composite nanofiber scaffolds seeded with skeletal muscle cells may provide implantable functional muscle tissues for patients with large muscle defects.

TL;DR: In this article, the authors show that the very properties that have established collagen as the leading natural biomaterial are lost when it is electro-spun into nano-fibres out of fluoroalcohols such as 1, 1,1,3, 3,3-hexafluoro-2-propanol or 2,2,2-trifluoroethanol.

TL;DR: Based on the need, the proposed fiber skin substitutes can be successfully fabricated and optimized for skin fibroblast attachment and growth and evaluated the efficacy of these biodegradable fiber matrices as skin substitutes.

TL;DR: In vitro, mesoporous silicates showed a significant degree of toxicity at high concentrations with mesothelial cells, and following subcutaneous injection of silicates in rats, the amount of residual material decreased progressively over 3 months, with good biocompatibility on histology at all time points.

TL;DR: Compared to covalent immobilization and physical adsorption, blended electrospinning of laminin and synthetic polymer is a facile and efficient method to modify nanofibers for the fabrication of a biomimetic scaffold.

TL;DR: The in vitro study suggests that calcium-containing magnesium alloys to be a promising candidate for their applications in degradable orthopaedic implants, and it is worthwhile to further investigate the in vivo corrosion behaviour of these alloys.

TL;DR: EGF-conjugated nanofiber could potentially be employed as a novel wound healing material by increasing proliferation and phenotypic expression of keratinocytes by exerting superior in vivo wound healing activities compared to control groups or EGF solutions.

TL;DR: Aligned electrospun poly(epsilon-caprolactone) (PCL) fibers were fabricated to test their potential to provide contact guidance to human Schwann cells and confirmed the propensity of aligned fibers in promoting Schwann cell maturation.

TL;DR: The matching of physical characteristics to those of the heart, the ability to fine tune degradation rates in biologically relevant media and initial data showing biocompatibility indicate that this material has promise for cardiac tissue engineering applications.

TL;DR: The synthesis of uniform silica coated hexagonal-phase NaYF(4) nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model revealed good in vitro and in vivo biocompatibility.

TL;DR: It is shown that the amplitude of the pulse has a small influence on cell survivability with regression analysis showing cell survival rates falling from 98% with a 40 V pulse (indistinguishable from control measurements) to approximately 94% with an 80 V pulse.

TL;DR: An intact form of UBM can be successfully solubilized without purification steps and induced to repolymerize into a gel form of the UBM biologic scaffold material, which supported the adhesion and growth of rat aortic smooth muscle cells when cultured under static in vitro conditions.

TL;DR: This present study aims to improve biocompatibility and confer long-lasting antibacterial properties on Ti via polyelectrolyte multilayers (PEMs) of hyaluronic acid and chitosan, coupled with surface-immobilized cell-adhesive arginine-glycine-aspartic acid (RGD) peptide.