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Showing papers in "Biomaterials in 2012"


Journal ArticleDOI
TL;DR: Progress towards controlled synthesis of alginate derivatives, and the properties and applications of these derivatives are reviewed.

1,182 citations


Journal ArticleDOI
TL;DR: An overview on the different rapid prototyping techniques suitable for the processing of hydrogel materials, and a primary distinction will be made between (i) laser-based, (ii) nozzle- based, and (iii) printer-based systems.

1,050 citations


Journal ArticleDOI
TL;DR: Advances in scientific knowledge on structural molecules, proteins, teichoic acids, and the most recently described extracellular DNA, on the synthesis and genetics of staphylococcal biofilms, and on the complex network of signal factors that intervene in their control are presented are presented, also reporting on the emerging strategies to disrupt or inhibit them.

870 citations


Journal ArticleDOI
TL;DR: The diverse roles played by macrophages in these processes are discussed in addition to the potential manipulation of macrophage effector mechanisms as a strategy for promoting site-appropriate and constructive tissue remodeling as opposed to deleterious persistent inflammation and scar tissue formation.

733 citations


Journal ArticleDOI
Kai Yang1, Jianmei Wan1, Shuai Zhang1, Bo Tian1, Youjiu Zhang1, Zhuang Liu1 
TL;DR: The results highlight that both surface chemistry and sizes are critical to the in vivo performance of graphene, and show the promise of using optimized nano-graphene for ultra-effective photothermal treatment, which may potentially be combined with other therapeutic approaches to assist the fight against cancer.

674 citations


Journal ArticleDOI
TL;DR: CD-PEI obtained at an appropriate pyrolysis time exhibited lower toxicity, higher or comparable gene expression of plasmid DNA in COS-7 cells and HepG2 cells relative to control PEI25k, suggesting the potential application of PEI in gene delivery and bioimaging.

641 citations


Journal ArticleDOI
Yan Cui1, Yuyun Zhao, Yue Tian, Wei Zhang, Xiaoying Lü1, Xingyu Jiang 
TL;DR: This investigation would allow the development of antibacterial agents that target the energy-metabolism and transcription of bacteria without triggering the ROS reaction, which may be at the same time harmful for the host when killing bacteria.

630 citations


Journal ArticleDOI
TL;DR: The results present essential knowledge for more efficient and innocuous applications of graphene sheets and particularly nanoplatelets in upcoming nanotechnology-based tissue engineering as, e.g., drug transporter and scaffolds.

629 citations


Journal ArticleDOI
TL;DR: Recent progress on mechanistic studies of cytotoxicity of II-IV QDs are summarized to suggest that the cytot toxicity of CdTe QDs not only comes from the release of C d(2+) ions but also intracellular distribution of QD nanoparticles in cells and the associated nanoscale effects.

612 citations


Journal ArticleDOI
TL;DR: Recent advances made in biophysical signals have been highlighted and how they have been utilized for neural, cardiac, and musculoskeletal tissue engineering application are highlighted.

598 citations


Journal ArticleDOI
TL;DR: Results demonstrated that the interconnectivity of pores allowed for uniform human umbilical vein endothelial cells (HUVECs) distribution and proliferation in the scaffolds, leading to high cell density and confluency at the end of the culture period.

Journal ArticleDOI
TL;DR: A clear association between macrophage phenotype and remodeling outcome exists and effective decellularization remains an important component in the processing of ECM-based scaffolds.

Journal ArticleDOI
TL;DR: TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles.

Journal ArticleDOI
TL;DR: The importance of this subject in biomaterials surface science is emphasized by reducing the "protein-adsorption problem" to three core questions that require quantitative answer, and several changes to the fundamental biophysical chemistry of protein adsorption are proposed.

Journal ArticleDOI
TL;DR: The use of enzymaticCrosslinking for the preparation of hydrogels as an innovative alternative to other crosslinking methods, such as the commonly used UV-mediated photo-crosslinking or physical crossl linking, will be discussed.

Journal ArticleDOI
TL;DR: Results suggest that redox-sensitive HA-ss-DOCA micelles hold great potential as targeted intracellular delivery carriers of lipophilic anticancer drugs.

Journal ArticleDOI
TL;DR: It is encouraging to conclude that iron oxide NPs bear the potential of its applications in biomedicine, such as tumor therapy specifically by inducing autophagy mediated cell death of cancer cells.

Journal ArticleDOI
TL;DR: The pathology, immune response, and blood biochemistry indicate that the PEG-coated gold nanoparticles have not caused spleen and kidney damages, but give rise to liver damage and gold accumulation, and these results have an important indication for possible radiotherapy and drug delivery.

Journal ArticleDOI
TL;DR: It is found that the pristine graphene can induce cytotoxicity through the depletion of the mitochondrial membrane potential (MMP) and the increase of intracellular reactive oxygen species (ROS), then trigger apoptosis by activation of the mitochondria pathway.

Journal ArticleDOI
TL;DR: It is reported on that G and GO can support the mouse iPSCs culture and allow for spontaneous differentiation, and implicate the potentials of graphene-based materials as a platform for iPSC culture and diverse applications.

Journal ArticleDOI
TL;DR: The as-designed nanoprobes showed strong emissions ranging from the visible (Vis) to near infrared (NIR) for fluorescent imaging, and enhanced HU value as a CT contrast agent and the potential of trimodal imaging for cancerous cells and lesions was further demonstrated both in vitro and in vivo.

Journal ArticleDOI
TL;DR: Results show that ECM hydrogel properties can be varied and partially controlled by the scaffold tissue source, and that these properties can markedly affect cell behavior.

Journal ArticleDOI
Xiaodong Zhang1, Di Wu1, Xiu Shen1, Pei-Xun Liu1, Feiyue Fan1, Saijun Fan1 
TL;DR: Findings show that the GSH-protected gold nanoclusters have small size and can be metabolized by renal clearance and thus the toxicity can be significantly decreased.

Journal ArticleDOI
TL;DR: The designed PEGylated Au DENPs can be used as a promising contrast agent with enhanced biocompatibility for CT imaging of various biological systems, especially in cancer diagnosis.

Journal ArticleDOI
TL;DR: The results showed that low amounts of Co (<5%) incorporated into MBG scaffolds had no significant cytotoxicity and that their incorporation significantly enhanced VEGF protein secretion, HIF-1α expression, and bone-related gene expression in BMSCs, and also that the Co-MBG scaffolding support BMSC attachment and proliferation.

Journal ArticleDOI
TL;DR: Electrochemically produced GQD irradiated with blue light generates reactive oxygen species, including singlet oxygen, and kill U251 human glioma cells by causing oxidative stress and a genetic inactivation of autophagy-essential LC3B protein partly abrogated the photodynamic cytotoxicity of G QD.

Journal ArticleDOI
TL;DR: It is demonstrated that hMSC osteogenesis can be induced via extracellular Ca(2+), a simple and economic way of priming hMSCs for bone tissue engineering applications.

Journal ArticleDOI
TL;DR: The results support that iCMBA technology is highly translational and could have broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.

Journal ArticleDOI
TL;DR: The results suggest that crosslinking electrospun hydroxyapatite-containing chitosan with genipin yields bio-composite scaffolds, which combine non-weight-bearing bone mechanical properties with a periosteum-like environment, which might be useful for the repair and regeneration of maxillofacial defects and injuries.

Journal ArticleDOI
TL;DR: Wounds treated with MSC-seeded hydrogels demonstrated significantly enhanced angiogenesis, which was associated with increased levels of VEGF and other angiogenic cytokines within the wounds.