Showing papers in "Biomaterials in 2016"

TL;DR: The state-of-the-art of topological design and manufacturing processes of various types of porous metals, in particular for titanium alloys, biodegradable metals and shape memory alloys are reviewed.

TL;DR: This paper, presenting a first-time comprehensive review of EBB, discusses the current advancements in EBB technology and highlights future directions to transform the technology to generate viable end products for tissue engineering and regenerative medicine.

TL;DR: P pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release, helping to design more efficient drug delivery systems.

TL;DR: A versatile 3D bioprinting strategy that employs biomimetic biomaterials and an advanced extrusion system to deposit perfusable vascular structures with highly ordered arrangements in a single-step process, superior to conventional microfabrication or sacrificial templating approaches for fabrication of the perfusable vasculature.

TL;DR: It is demonstrated that the method for generation of endothelialized organoids fabricated through an innovative 3D bioprinting technology may find widespread applications in regenerative medicine, drug screening, and potentially disease modeling.

TL;DR: A first-time review of DBB is presented and comprehensively covers the existing DBB modalities including inkjet, electrohydrodynamic, acoustic, and micro-valve bioprinting.

TL;DR: Recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration are discussed.

TL;DR: This review highlights the current research in bone biofabrication, the necessary factors for success, in addition to the current limitations affecting biofabricsation, some of which are a consequence of the limitations of the additive manufacturing technology itself.

TL;DR: GDNPs 2, nanoparticles derived from edible ginger, represent a novel, natural delivery mechanism for improving IBD prevention and treatment with an added benefit of overcoming limitations such as potential toxicity and limited production scale that are common with synthetic nanoparticles.

TL;DR: Water-soluble and biocompatible PEGylated BP nanoparticles with a high yield were prepared by one-pot solventless high energy mechanical milling technique and exhibit excellent photostability, which makes them suitable as a novel nanotheranostic agent for photoacoustic (PA) imaging and photothermal therapy of cancer.

TL;DR: The main variations discussed herein encompass aspects of donor selection, preparation of the starting material, the possibility for pooling in plasma or additive solution, the implementation of pathogen inactivation and consideration of ABO blood groups, all of which can influence applicability.

TL;DR: The rational design of a NMOF composed by hafnium (Hf(4+)) and tetrakis (4-carboxyphenyl) porphyrin (TCPP) is reported, which shows efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity.

TL;DR: In vitro and in vivo studies demonstrated that PDA-PEG-mediated PT-CT showed synergetic effect for cancer therapy and showed great stability and drug-retaining capability in physiological condition.

TL;DR: Current ECM-derived biomaterials characterization methods including relationships between ECM material compositions from different sources, properties and host tissue response as implants are discussed.

TL;DR: By understanding the design and production processes of these emerging technologies, one can gain tremendous insight into how to best use them and also how to design the next generation of tissue engineered cartilage products.

TL;DR: The review begins with a discussion of superhydrophobicity, and then explores biomedical applications that are utilizingsuperhydrophobic biomaterials for medical applications in depth including material selection characteristics, in vitro performance, and in vivo performance.

TL;DR: This review provides a summary on the current development of electroconductive natural polymer-based hydrogels (ENPHs) and introduced various types of ENPHs, with a brief description of their advantages and shortcomings.

TL;DR: This paper presents a strategy for hierarchical TiO2/Ag coating, in an attempt to endow medical titanium (Ti) with anticorrosion and antibacterial properties whilst maintaining normal biological functions, and shows good degree of flexibility towards three-dimensional sophisticated objects.

TL;DR: The Scavenger Receptor Class A family (SR-A) is identified as a novel monocyte/macrophage uptake receptor for EV and blockade of SR-A with dextran sulfate dramatically decreased EV liver clearance in mice, while enhancing tumor accumulation.

TL;DR: A highly tunable conductive biodegradable flexible polyurethane by polycondensation of poly(glycerol sebacate) and aniline pentamer is presented, to significantly enhance SCs' myelin gene expression and neurotrophin secretion for peripheral nerve tissue engineering.

TL;DR: Interestingly, HA-dOG-PTX-PM could effectively treat mice bearing MCF-7 human breast tumor xenografts with little side effects, resulting in complete inhibition of tumor growth and a 100% survival rate over an experimental period of 55 days, indicating that hyaluronic acid-shelled acid-activatable PTX prodrug micelles have a great potential for targeted chemotherapy of CD44-positive cancers.

TL;DR: The necessity to further study OsteoMacs and MNGCs to understand their function in bone biomaterial tissue integration including dental/orthopedic implants and bone grafting materials is expressed.

TL;DR: The feasibility of directing corona composition to promote targeted NP uptake by specific types of cells is investigated, and it is demonstrated that pre-coating silica NPs with gamma-globulins produced a protein corona that was enriched with opsonins, such as immunoglobulin.

TL;DR: Genetically engineered CpG-SAV-exo is an effective exosome-based tumor antigens-adjuvant co-delivery system that will be useful for cancer immunotherapy.

TL;DR: A cell-mediated delivery and therapy system by employing macrophage vehicles to transport 7 nm diameter Au nanorods (sAuNRs) provides a desirable approach to improve the photothermal therapy efficiency by optimizing the intratumoral distribution of the agents, but also expedite clinical application of nanotechnology to cancer treatment.

TL;DR: An overview of the primary clinical treatment strategies and emerging biodegradable materials that may be employed for management of implant-related osteomyelitis is provided and a systematic review of experimental biomaterials systems that have been evaluated for treating established S. aureus osteomyeliitis in an animal model is performed.

TL;DR: The in vivo results demonstrated that drug loaded HMSNs significantly inhibited tumor growth while only with minimal toxic side effects, providing new insight into the development of new generation of drug delivery carriers triggering by tumor microenvironment.

TL;DR: The distinctive multimodal imaging capability, excellent synergistic therapy effect through the combined chemo-photothermal therapy together with the low toxicity of both d-MOFs and artemisinin endow the theranostic nanoagent a promising next generation of nanomedicine for efficient and safe cancer therapy.

TL;DR: A "Trojan Horse" strategy of neutralizing CTCs to attenuate metastasis is demonstrated and a unique "microenvironment" was confirmed upon introduction of cancer cells of different types into circulation where activated platelets and fibrin were physically associated with blood-borne cancer cells.

TL;DR: A facile supramolecular approach for preparing gelatin hydrogels with a wide array of desirable properties that are capable of sustaining excessive compressive and tensile strain and capable of quick self healing after mechanical disruption is described.