Biomedical sciences instrumentation 

About: Biomedical sciences instrumentation is an academic journal. The journal publishes majorly in the area(s): Poison control & Thymoquinone. It has an ISSN identifier of 0067-8856. Over the lifetime, 1669 publications have been published receiving 12722 citations.

A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier.

Abstract: In the recent decade, the most useful drug for the therapy of colon cancer is 5-Fluorouracil(5-FU). It has been reported to have considerable toxicity administered by intravenous injections or via alimentary treat. Though many materials have developed for drug carrier of 5-FU, there was no clinically acceptable carrier for 5-FU till now. Montmorillonite, one of clay minerals, consists of hydrated aluminum silicates that are fined grained and usually have a large space between the layers. Isomorphous substitution of cations is common. We try to intercalate 5-FU into interlayer of montmorillonite through ion-exchange. Montmorillonite with 5-FU intercalation is expected to achieve in-situ release for colon cancer therapy. In the study, 5-FU was dissolved in 100 ml distilled water as 5-FU solution. Purified montmorillonite powder will soak in 5-FU solution for a period of time ad different pH value and temperature. The intercalated amount of 5-FU in montmorillonite is measured by scanning differential thermal (SDT) analysis and UV analysis. The results showed that 4 g purified montmorillonite soaked in 0.6% 5-FU solution for 2 hours had an optimum condition for intercalation. The total amount of 5-FU in montmorillonite is about 9.13 wt%.

Patient monitoring using personal area networks of wireless intelligent sensors.

Abstract: A wearable device for monitoring multiple physiological signals (polysomnograph) usually includes multiple wires connecting sensors and the monitoring device. In order to integrate information from intelligent sensors, all devices must be connected to a Personal Area Network (PAN). This system organization is unsuitable for longer and continuous monitoring, particularly during the normal activity. For instance, monitoring of athletes and computer assisted rehabilitation commonly involve unwieldy wires to arms and legs that restrain normal activity. We propose a wireless PAN of intelligent sensors as a system architecture of choice, and present a new design of wireless personal area network with physiological sensors for medical applications. Intelligent wireless sensors perform data acquisition and limited processing. Individual sensors monitor specific physiological signals (such as EEG, ECG, GSR, etc.) and communicate with each other and the personal server. Personal server integrates information from different sensors and communicates with the rest of telemedical system as a standard mobile unit. We present our prototype implementation of Wireless Intelligent SEnsor (WISE) based on a very low power consumption microcontroller and a DSP-based personal server. In future we expect all components of WISE integrated in a single chip for use in a variety of new medical applications and sophisticated human computer interfaces. Existing growth of wireless infrastructure will allow a range of new telemedical applications that will significantly improve the quality of health care.

Are all measures created equal? Heart rate variability and respiration - biomed 2009.

Abstract: There is considerable controversy with regards to which index of heart rate variability (HRV) is the most reliable across multiple situations. Recent evidence from Pentilla and colleagues (2001) suggests that certain indices of HRV appear to be less affected by fluctuations in respiration, and may thus be a more robust indicator of parasympathetic (vagal) influence. In the present investigation, we sought to replicate and extend this report by exploring the relations between, impedance cardiography-derived respiration parameters (rate and amplitude) and time and frequency domain indices of heart rate variability in a multiethnic sample of healthy men and women (n=39; mean age = 20.33 +/- 3.47yrs). Preliminary results support Pentilla et al.'s finding that rMSSD is relatively free of respiratory influences (r = -.06 to .21; ns), and extends this work to a multiethnic sample. In conclusion, some measures of HRV appear to be relatively free of respiratory influences while others appear less so, independent of the subjects' ethnicity.

Head acceleration is less than 10 percent of helmet acceleration in football impacts.

Abstract: Sports-related concussions constitute 20 percent of brain injuries each year in the United States. Concussion research has included a variety of instrumentation and techniques to measure head accelerations. Most recently, the Head Impact Telemetry (HIT) System (Simbex, Lebanon, NH), a wireless system that provides real-time data from impacts, is used to measure in-situ head accelerations in collegiate football. The purpose of this study is to compare helmet shell acceleration to head center of gravity acceleration using two measures of linear head acceleration. A study of 50 helmet to helmet impact tests using a pendulum provided a range of head accelerations from 5 g to 50 g. The primary measure of head acceleration is accelerometers mounted at the center of gravity of the Hybrid III head. A secondary measure is the in-helmet HIT System. The series of 50 pendulum impacts included three impact velocities of 2.0 m/s, 3.5 m/s and 5.0 m/s at four different impact locations. The impact locations were on the side, back, top and just above the facemask on the front. By comparing these two measured head accelerations and the helmet acceleration during a pendulum impact, it is shown that the response of the head and the helmet vary greatly and the in-helmet system matches the head and not helmet acceleration. Specifically, head acceleration is less than 10 percent of helmet acceleration in football impacts; moreover, the HIT System is able to accurately measure the head acceleration.