Showing papers in "Biomedicine & Pharmacotherapy in 2016"

TL;DR: Results of the present study suggest that curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.

TL;DR: Curcumin treatment attenuates LPS-induced PI3K/AKT and CYP2E/Nrf2/ROS signaling and liver injury and strategies to inhibit inflammation and apoptosis signaling may provide alternatives to the current clinical approaches to improve oxidative responses of endotoxemia.

TL;DR: The cytotoxicity studies revealed that Ln-ZnO NPs showed no effect on normal murine RAW264 cells and were effective in inhibiting the viability of human A549 lung cancer cells at higher concentrations of 80μgmL-1.

TL;DR: The association between the development of oral cancer in potentially malignant oral lesions with chronic periodontitis, chronic Porphyromonas gingivalis, Fusobacterium nucleatum, candida, other microbes and described mechanisms which may be involved in these carcinoma are discussed.

TL;DR: LGG have a potential protection effect against colon carcinogenesis; inducing apoptosis and ameliorating inflammation, and may hold a promise as bio-therapeutic dietary agent.

TL;DR: The current review focuses on summarizing the recent findings on the neuroprotective effect of quercetin, its mechanism of action and its possible roles in the prevention of neurological disorders.

TL;DR: Investigation of the clinical significance and functions of lncRNA-small nucleolar RNA host gene 1 (SNHG1) in Hepatocellular carcinoma found it was upregulated in HCC tissues in comparison with adjacent liver tissues in both publicly available microarray data and the own cohort.

TL;DR: This review article presents the most important studies connected with the influence of free radicals on development of AD and antioxidants as potential drugs toward AD.

TL;DR: Photodynamic therapy can be considered as promising treatment with comparable effectiveness but without side effects characteristic for chemotherapy.

TL;DR: This review summarizes Al induced events likewise oxidative stress, cell mediated toxicity, apoptosis, inflammatory events in the brain, glutamate toxicity, effects on calcium homeostasis, gene expression and Al induced Neurofibrillary tangle (NFT) formation.

TL;DR: The central focus of this review is to provide an overview of the role that the major tea polyphenol, EGCG plays in preventing cancer, cardiovascular and neurodegenerative diseases.

TL;DR: The potential roles of microRNAs as potential biomarkers for CRC diagnosis, and treatment are summarized.

TL;DR: The present review discusses about some of the most successful drugs in RA therapy and their side effects and also focuses on key design parameters of RA-targeted nanotechnology-based strategies for improving RA therapies.

TL;DR: The green AgNPs are effective and safer to the milieu as they show less toxic effect to normal cells and can be extensively applied in biomedical sciences particularly in cancer field.

TL;DR: Results showed that P.g AgNPs exhibited anti-cancer activity in A549 and the regulation of EGFR/p38 MAPK/p53 pathway might be the possible mechanism of its anti-activity.

TL;DR: Spirulina supplementation could overcome DLM-induced hepatotoxicty, nephroprotective, neuroprotective and neurotoxicity by abolishing oxidative tissue injuries in a dose-dependent manner.

TL;DR: In this article, the effect of miR-21 inhibition on the function of autophagy and apoptosis of breast cancer cells was investigated. And the authors found that miR21 inhibition significantly increased the TAM or FUL-induced apoptosis in ER(+) breast cells.

TL;DR: Findings indicate that rutin, a natural molecule, might have potential as anticancer agent against lung and colorectal carcinogenesis.

TL;DR: The role of Nps in the treatment of GBM is discussed and different types of nanoparticles (Nps) which can be manipulated for clinical applications as a treatment for CNS-related disorders are discussed.

TL;DR: Gensitein possesses cancer related enzyme-inhibitory effect and substantially inhibits skin carcinogenesis and cutaneous aging induced by ultraviolet (UV) light in mice and photodamage in humans.

TL;DR: It is suggested that resveratrol protects against LPS-induced lung injury by NLRP3 inflammasome inhibition, and may be of great value in the treatment of ALI and a potential and an effective pharmacological agent for inflamMASome-relevant diseases.

TL;DR: Results indicated that quercetin nanoparticle could induce autophagy and apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partly, through activation LC3/ERK/Caspase-3 and suppression AKT/mTOR signaling.

TL;DR: Investigation indicated that astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor κB (NLRP3/NF-κB), which presented a renal protective role by suppression oxidative stress.

TL;DR: This review presents a concise account of the key findings in recent years with adequate elaboration of the mechanisms of cardiac glycosides as peruvoside, expected to contribute towards management of cardiac, cancer, even viral ailments.

TL;DR: Results suggest that p-CA modulates glucose and lipid metabolism via GLUT 2 activation in the pancreatic and has potentially beneficial effects in improving or treating metabolic disorders.

TL;DR: The results support the involvement of miR-138 in breast tumorigenesis, especially lymph node metastasis, and propose that mi R-138 might be used as therapeutic agent for breast cancer.

TL;DR: It is found that AFAP1-AS1 was aberrantly over-expressed in CRC tissues and closely correlated with tumor size, TNM stage and distant metastasis and significantly up-regulated in CRC, which may act as an oncogene and correlate with tumor malignant progression and poor prognosis of CRC.

TL;DR: The combination of RSV and lower dose of SF at 6μM showed enhanced apoptotic activity than SF alone and RSV can be considered as a neo-adjuvant to improve SF efficacy in breast cancer treatment.

TL;DR: Novel urinary exosomal miRNA biomarkers of DN were identified which were altered not only in micro and macroalbuminuric groups but also in some normoalbuminuria cases prior to albuminuria.

TL;DR: It is suggested that miR-221/222 enhance breast cancer growth, migration and invasion, meanwhile propagate the self-renewal of BCSCs through targeting PTEN/Akt pathway.