Showing papers in "Biomedicine & Pharmacotherapy in 2017"

TL;DR: This is an update article (between 2013 and 2016) on the recent progress, characteristics and synthesis methods of CQDs and different advantages in varieties of applications.

TL;DR: The efficacy and safety of curcumin phytosomes have been shown against several human diseases including cancer, osteoarthritis, diabetic microangiopathy and retinopathy, and inflammatory diseases.

TL;DR: Important facets of RAAS are discussed, its crosstalk with other crucial factors like estrogen, thyroid, cortisol, kallikrein-kinin system, Wnt/β-catenin signaling, and sodium-potassium pump, which can contribute to better management of an array of pathologies plaguing mankind.

TL;DR: Copper oxide nanoparticles synthesized by green method exhibited high antioxidant and cytotoxicity than that synthesised by chemical method, and was evaluated against four cancer cell lines.

TL;DR: The results of current experimental studies support the potential of rutin to prevent or treat pathologies associated with diabetes, and well-designed clinical studies are suggested to evaluate advantages and limits of r Rutin for managing diabetes.

TL;DR: Inhibition of PI3K/AKT/mTOR signaling pathway could promote the autophagy of articular chondrocytes and attenuate inflammation response in rats with OA.

TL;DR: The data suggest that tumor-infiltrating immune cells in lung cancer are likely to be important determinants of both prognosis and response to immunotherapies.

TL;DR: New agents need to be explored, whether from synthetic or natural source, to find the answers for unresolved etiology of autoimmune diseases and to provide a quality of life to the patients suffering from these diseases specifically RA.

TL;DR: This work confirmed the cardiac tolerability profile of LD and PLD versus DOX, while hematological and skin toxicities were more common, and shows that the full clinical potentiality of DOX-NPs remains to be addressed to move the field forward.

TL;DR: The aim of this review is to present features of a frequently used model of type-2 diabetes in rat, induced by a high fat diet and streptozotocin, taking into account its advantages/disadvantages and presenting a practical guide.

TL;DR: In conclusion, anticancer effects of phytosterols have strongly been suggested and support their dietary inclusion to prevent and treat cancers.

TL;DR: CUR can prevent restraint stress-induced oxidative damage in the brain, liver and kidney of rats and it is proposed that CUR may be useful agents against oxidative stress in the tissues.

TL;DR: Inter and intra- tumor heterogeneity of GMB is described, recent chemotherapeutic agents, with their mechanism of action have been defined and FDA-approved drugs also been focused on.

TL;DR: Human circRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUV ECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis.

TL;DR: This review presents an overview of the current findings related to TP toxicity with an emphasis on biological targets and the molecular mechanisms that may be involved, thus providing a systematic understanding of the mechanisms by which TP affects cells and tissues in vitro and in vivo.

TL;DR: This work summarises current predictive and prognostic biomarkers with their potential for diagnostic and therapeutic applications, and describes current limitations, future perspectives and challenges associated with the progression of CRC.

TL;DR: The present review is aimed to extend the current knowledge by highlighting the importance and beneficial applications of green tea in humans for safeguarding various health issues by extensively reviewed, analyzed, and compiled salient information on green tea from the authentic published literature available in PubMed and other scientific databases.

TL;DR: The research indicated that MEG3 regulated the expression of miR-133a-3p, and inhibited the osteogenic differentiation of BMSCs induced PMOP.

TL;DR: The notion that iNOS is a detrimental enzyme in disease is addressed and its potentially beneficial roles are discussed and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD).

TL;DR: This review focuses on the ability of the green tea constituents to suppress angiogenesis signaling and it summarizes the mechanisms by which EGCG might inhibit the VEGF family.

TL;DR: This review focuses on the advances made in the field in recent years using a representative set of studies to highlight the challenges encountered such as the need to increase mechanical strength as well as medication dose while ensuring fast release of the active ingredient.

TL;DR: It is demonstrated that dysregulated circ-BANP appears to have an important role in CRC cells and could serve as a prognostic and therapeutic marker for CRC.

TL;DR: Investigations show that flavonoids may have health-promoting and disease-preventing dietary compounds with important benefits in modern life styles and chrysin by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries.

TL;DR: The hepatoprotective effects of UMB appear to depend on co-activation of PPARγ and Nrf2, and subsequent suppression of oxidative stress and inflammation.

TL;DR: This mini-review provides a critical overview of currently available clinical studies examining the effects of resveratrol in DM last decade and suggests that the use of the compound alone or in combination with current anti-diabetic therapies, might be a conventional approach to effectively manage DM or its complications.

TL;DR: This study demonstrated that baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT and attenuating apoptosis via PI3K/Akt/NF-κB pathway.

TL;DR: The data support the traditional use of R. officinalis as an effective remedy for pain relief and inflammatory disorders and suggests that the ethanolic extract ofR.

TL;DR: Taken together, baicalein may be developed as a potential, novel anticancer drug for HCC treatment and their underlying molecular mechanisms based on in vitro and in vivo experimental evidences discovered so far are summarized.

TL;DR: It is determined that quercetin, which was non-toxic, produced better results than methotrexate for the protection of joints from arthritic inflammation in mice.

TL;DR: BBR attenuated MTX-induced oxidative stress and apoptosis, possibly through up-regulating Nrf2/HO-1 pathway and PPARγ, therefore, BBR can protect against methotrexate (MTX)-induced liver injury.