Showing papers in "Bioorganic & Medicinal Chemistry Letters in 2007"

TL;DR: Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera.

TL;DR: The identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described and the leading compound, 17 (AZD6140), is currently in a large phase III clinical trial for the treatment of acute coronary syndromes and prevention of thromboembolic clinical sequelae.

TL;DR: New HDAC inhibitors designed to exploit a unique sub-pocket in the HDAC8 active site that is unusually malleable and can accommodate inhibitor structures that are distinct from the canonical 'zinc binding group-linker-cap group' structures of SAHA, TSA, and similarHDAC inhibitors.

TL;DR: The quantification with real-time PCR after conventional bisulfite treatment for methylcytosine-selective hydrolysis showed a large decrease in the amount of full-length DNA.

TL;DR: In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. a Aureus, Escherichia coli, Candida albicans, and Candida krusei.

TL;DR: These nanoparticles formed in water by emulsion polymerization of an acrylated antibiotic pre-dissolved in a liquid acrylate monomer have potent in vitro antibacterial properties against methicillin-resistant Staphylococcus aureus and have improved bioactivity relative to the non-polymerized form of the antibiotic.

TL;DR: A simple 'fit quality' metric is proposed that removes dependence on size for ligand efficiency and shows conclusively that the average ligand binding affinities are not linear with molecular size.

TL;DR: The dual inhibition of alpha- and/or beta-class CAs of H. pylori might represent a useful alternative for the management of gastritis/gastric ulcers, as well as gastric cancer.

TL;DR: A hydrogen bond matrix involving the Pim-1 inhibitor, two water molecules, and the catalytic core, together with a potential weak hydrogen bond between an aromatic hydrogen on the R(1) phenyl ring and a main-chain carbonyl of Pim -1 accounts for the overall potency of this inhibitor.

TL;DR: The identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage is reported.

TL;DR: A novel hybrid molecule that was reduced to dihydroartemisinin and coupled to a carboxylic acid derivative of quinine via an ester linkage had potent activity against the 3D7 and (drug-resistant) FcB1 strains of Plasmodium falciparum in culture.

TL;DR: The results suggest that phthalazine-5,8-diones would be potent antifungal agents.

TL;DR: A simple, clean and environmentally benign route to the synthesis of 2-amino-4H-chromenes is described using Preyssler type heteropolyacid, H(14)[NaP(5)W(30)O(110)], as a green and reusable catalyst in water.

TL;DR: Evaluation of isoform selectivity showed that 10e is a potent inhibitor of p110beta, and 10e showed anti-proliferative activity in various cell lines, including multi-drug resistant MCF7/ADR-res cells, and was effective against HeLa human cervical tumor xenografts in nude mice.

TL;DR: Molecular iodine efficiently catalyzes the reaction of beta-naphthol and araldehydes on a preheated hot plate at 90-95 degrees C to give biologically active aryl-14H-dibenzo[a, j]xanthenes under solvent-free condition.

TL;DR: This work identified the potent and selective A2A antagonist 11h, orally active in the rat haloperidol-induced catalepsy model, and optimized this lead to the methoxyethoxyethyl ether 12a (SCH 420814), which shows broad selectivity, good pharmacokinetic properties, and excellent in vivo activity.

TL;DR: In this investigation for free radical scavengers from the methanolic extract of this mushroom, inonoblins A, B, and C were isolated along with the known compounds, phelligridins D, E, and G, and showed moderate activity against the superoxide radical anion.

TL;DR: Phenanthrene imidazole 3 (MF63) has been identified as a novel potent, selective, and orally active mPGES-1 inhibitor and exhibited a significant analgesic effect in a guinea pig hyperalgesia model when orally dosed at 30 and 100mg/kg.

TL;DR: The anticipated differences between acidic, basic and neutral compounds are apparent in the data but lipophilicity is shown to be a stronger driver for hERG potency than might have been expected.

TL;DR: A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies.

TL;DR: Molecular modeling studies showed that these compounds possess a twisted conformation similar to CA-4 (1), and a similar compound with an acetyl group at N1 of the pyrazoline ring showed poor activity in the cell lines studied.

TL;DR: The synthesis, anti-inflammatory and antioxidant activities of novel ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues are reported.

TL;DR: The preparation of antibacterially active emulsified polyacrylate nanoparticles in which a penicillin antibiotic is covalently conjugated onto the polymeric framework have equipotent in vitro antibacterial properties against methicillin-susceptible and methiillin-resistant forms of Staphylococcus aureus and indefinite stability toward beta-lactamase.

TL;DR: The reasonable mapping of compound 2 to validated pharmacophoric hypothesis and 3D QSAR model with an estimated activity suggest that the compound 2 might be a beta(3)-AR agonist.

TL;DR: Two atom efficient, green protocol for the synthesis of fifteen 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles and isoniazid was found to be the most potent compound against MTB and MDR-TB.

TL;DR: A computational approach was used to calculate the theoretical reactivities of diverse nitriles and this was found to correlate with their extent of reactivity with free cysteine, suggesting a tentative link between high reactivity of nitrile-containing inhibitors and the potential to lead to irreversible covalent binding to proteins.

TL;DR: The first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acids binding protein and epidermal fatty acidbinding protein is reported.

TL;DR: Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay.

TL;DR: Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.

TL;DR: These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity and were evaluated for their ability to inhibit TNFalpha production in U937 cells and in vivo.