Showing papers in "Bioorganic & Medicinal Chemistry in 2012"

TL;DR: In the present review, various derivatives of benzimidazole with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimdazole derived compounds for each activity.

TL;DR: This review addresses the areas such as the underlying mechanisms, eight different targets such as ergosterol synthesis, chitin synthesis, ergosterols disruptors, glucan synthesis, squalene epoxidase, nucleic acid synthesis, protein synthesis, microtubules synthesis, and the current research work going on worldwide on different heterocycles.

TL;DR: The present review describes these differently synthesized coumarin derivatives as AChE inhibitors for management of AD.

TL;DR: This review aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011 and presents data for active compounds, some of which have passed the preclinical testing stage.

TL;DR: This review summarizes recent advances in the use of diazirines in photoaffinity labeling to study ligand-receptor,ligand-enzyme and protein-protein interactions, and in the isolation and identification of unknown proteins.

TL;DR: This review will present an overview of the cleavable linkers used in chemical biology classified according to their cleavage conditions by enzymes, nucleophilic/basic reagents, reducing agents, photo-irradiation, electrophilic/acidic reagent, organometallic and metal re agents, oxidizing reagents.

TL;DR: It is identified that all of the isolated tanshinones are good inhibitors of both cysteine proteases and these findings provide potential inhibitors for SARS-CoV viral infection and replication.

TL;DR: Synthesized compounds were tested in vitro for antibacterial and antifungal activity and some analogues exhibited very promising results especially as antIFungal agents.

TL;DR: This work optimized the side-chains and identified highly selective, orally active and potent ALK inhibitor CH5424802 (18a) as the clinical candidate.

TL;DR: Overall, 3f showed promising antioxidant and anti-inflammatory activities and may be used as the lead compound in a future study.

TL;DR: A number of triazolo-benzodiazepines including drugs such as alprazolam have been developed as protein interaction inhibitors that target bromodomains of the BET family.

TL;DR: A highly potent, selective, long-lasting and orally active DPP-4 inhibitor, 3-[(2S,4S)-4]-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin- 1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine (8 g), which has a unique structure characterized by five consecutive rings.

TL;DR: New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was evaluated using in vitro cyclooxygenase (COX) inhibition assay, and the anti-inflammatory activity of selected compounds was investigated in vivo using carrageenan-induced rat paw edema model.

TL;DR: A novel benzothiophene derivative was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-A(y) mice and STZ rats.

TL;DR: The arachidonoyl amides were positively tested for cannabis receptor binding and cyclooxygenase inhibition and suggest that the endogenous cannabinoid system may play a role in the effects of dipyrone against pain.

TL;DR: Different multi-substituted chalcones for their BCRP inhibition were investigated and Substituents at position 2' and 4' on chalcone ring A were found to be essential for activity; additionally there was a great influence of substituents on ring B.

TL;DR: A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinease (BuChE).

TL;DR: The structure-activity relationship for these classes of less investigated CA inhibitors are delineated, with the potential of using them as leads to obtain isoform-selective inhibitors with excellent affinity for CA IX and XII (validated antitumor targets) which do not significantly inhibit the cytosolic offtarget isoforms hCA I and II.

TL;DR: The findings suggest that novel potent and specific AMPK activators can be discovered from natural and synthetic sources that have potential to be used for anti-cancer therapy in the clinic.

TL;DR: This review aims to highlight tandem photoaffinity labeling-bioorthogonal conjugation as a chemical approach in medicinal chemistry and chemical biology and recent examples of using this strategy for affinity-based protein profiling, drug target identification, binding ensemble profiling, studying endogenous biological molecules, and imaging applications will be presented.

TL;DR: A comparison of minimum inhibitory concentrations (MICs) of known bacteriostatic agents in wild-type and resistant strains indicates a novel mechanism of action of this new chemotype.

TL;DR: The aromatic MBHA is highlighted, which have shown diverse biological activities as anti-Leishmania chagasi and Leishmania amazonensis, anti-Trypanosoma cruzi, lethal against Biomphalaria glabrata, antibacterial, antifungal, herbicide and actives against some human tumor cell lines.

TL;DR: Overall, the imidazo[1,2-a]pyridine class was determined to be most promising, with potency similar to isoniazid and PA-824 against replicating Mtb H(37)Rv, clinically relevant drug sensitive, multi- and extensively resistant Mtb strains as well as having good in vitro metabolic stability.

TL;DR: A correlation between the membrane toxicity and the reduction in surface tension was revealed and a variety of saponins with distinct structures were tested.

TL;DR: This review describes experimental strategies in currentchemical proteomics research, discusses recent examples of successful applications, and highlights areas in drug discovery where chemical proteomics-based assays using native endogenous proteins are expected to have substantial impact.

TL;DR: Results of this study put forward compound 6 as a potential novel antitumor agent (IMPDH inhibitor) for treating leukaemia because of its significant biological activity and low toxicity in human diploid fibroblasts, encourage further development of this compound as a lead.

TL;DR: It is reported that methotrexate is released by the photochemical mechanism in an actively controlled manner and varies in response to multiple control parameters, including linker design, light wavelength, exposure time, and the pH of the medium where the drug release occurs.

TL;DR: The first multi-target (mt) approach for the virtual screening and rational in silico discovery of anti-CRC agents against ten cell lines is developed, which correctly classified more than 90% of active and inactive compounds in training and prediction sets.

TL;DR: An alternative approach based on the use of utility functions, within the framework of the analytic hierarchy process (AHP), are employed to 'soften' the sharp boundaries inherent in classical sets, providing a more realistic assessment of compounds in terms of their potential suitability in drug-discovery research programs.

TL;DR: Based on the preliminary results, compound 10e with potent inhibitory activity in tumor growth may be a potential anticancer agent.