Showing papers in "Bioorganic & Medicinal Chemistry in 2013"

TL;DR: An extensive analysis of all 16 mammalian CAs for its structure and function is performed in order to establish a structure-function relationship, and the role of CA in carbon capture, carbon sensor and metabolon is discussed.

TL;DR: Several small molecule compounds that specifically bind to the Keap1 Kelch-DC domain are identified as measured by NMR, native mass spectrometry and X-ray crystallography and one compound upregulates Nrf2 response genes measured by a luciferase cell reporter assay.

TL;DR: The current understanding of diversity and function of carbonic anhydrases in corals is reviewed and the perspective of theses enzymes as a key to understanding impacts of environmental changes on coral reefs is discussed.

TL;DR: Structural analysis of new compounds produced by the MeOH extracts of the fruits of the Paulownia tree showed that they all contain a 3,4-dihydro-2H-pyran moiety, a very rare chemotype derived from cyclization of a geranyl group with a phenol functionality.

TL;DR: The current review highlights the design and synthetic methods of coumarin derivatives as well as coumarins obtained from plant source as MAO inhibitors for treatment of depression and Alzheimer disease with salient finding related to structure-activity relationship.

TL;DR: Results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment and have a great potential and significance for further investigations.

TL;DR: Phlorotannins have been isolated and are the first of their type showing competitively inhibitory activity toward SARS-CoV 3CLpro, and Dieckol showed the most potent SARsCoV3CLpro trans/cis-cleavage inhibitory effects with high association rate.

TL;DR: The discovery of the ubiquitin-proteasome system resolved the enigma and it is recognized that degradation of intracellular proteins is involved in regulation of a broad array of cellular processes, such as cell cycle and division, regulation of transcription factors and assurance of the cellular quality control.

TL;DR: This work has focussed its attention on the collected synthetic simple Schiff bases of aldimine- and ketIMine-types revealing anticancer activities in vitro, that have been described in the scientific literature during the last decade, and on structural variations whose affect the antiproliferative activity in sets of the designed molecules.

TL;DR: Pyrazolealdehydes, Knoevenagel's condensates, and Schiff's bases of curcumin-I were synthesized, purified and characterized and it was observed that DNA-compound adducts were stabilized by three governing forces (Van der Wall's, H-bonding and electrostatic attractions).

TL;DR: The human (h) isozymes hCA I and hCA II have been investigated in this study by using an esterase assay with 4-nitrophenyl acetate as substrate, and the new sulfamides showed inhibition constants in the micro-submicromolar range.

TL;DR: In the present review, various derivatives of thiazolidine-2,4-diones with different pharmacological activities are described on the basis of substitution pattern around the nucleus combined with the docking studies performed in the active site of the corresponding receptors with an aim to help medicinal chemists for developing an SAR for each activity.

TL;DR: The present manuscript to the best of the authors' knowledge is the first compilation on synthesis and medicinal aspects including structure-activity relationships of pyrazolo[3,4-d]pyrimidines reported to date.

TL;DR: A series of novel sulfamides incorporating the dopamine scaffold may lead to inhibitors targeting medicinally relevant CA isoforms with potential applications as antiepileptic, antiobesity antitumor agents or anti-infective.

TL;DR: The results clearly indicate that Fmoc-FF based hydrogel nanoparticles have the potential to be used as encapsulation and delivery system of various drugs and bioactive molecules.

TL;DR: The biochemical properties, thermostability and inhibition of SazCA were compared with those of the thermophilic and mesophilic counterparts, demonstrating the special features of this unique enzyme.

TL;DR: This article focuses on CA IX inhibition and two different structural approaches to CA isoform specific drug designing: tail approach and fragment addition approach.

TL;DR: This review makes an attempt to summarise the work carried out in the period from 2006 until mid-2012 on chemical modifications of oxazolidinones, a new and potent class of antimicrobial agents with activity mainly against Gram-positive strains.

TL;DR: Molecular docking and 3D-QSAR study supported that compound 18 can be selected as dual antitumor/antibacterial candidate in the future study.

TL;DR: This paper examines the role of mitochondrial carbonic anhydrase (CA) isozymes in the metabolism of pyruvate, acetate, and succinate when specific isozyme inhibitors are present and found that certain sulfonamide analogues displayed broad spectrum inhibition of metabolism, where others only had significant effect on some metabolic pathways.

TL;DR: This study is the first to more widely investigate NP coumarins for CA inhibition following the recent discovery of aNP coumarin CA inhibitor, and provides a platform to support further evaluation of NPs for the discovery of new chemotypes that inhibit disease relevant CA enzymes.

TL;DR: The direct C-H-bond arylation of the complex spirocyclic lactones 13, 14, and 18 allows the introduction of diverse aryl moieties in the last step of the synthesis and shows increased σ1 affinity compared to the non-arylated parent compounds.

TL;DR: Three-component reaction of a series of 1-acryloyl-3,5-bisbenzylidenepiperidin-4-ones with isatin and L-proline in 1:1:1 and 1:2:2 molar ratios in methanol afforded the piperidone-grafted novel mono- and bisspiro heterocyclic hybrids in good yields.

TL;DR: Among the isolates, (S)-(+)-sydonol did not only potentiate insulin-stimulated glucose consumption but also prevented lipid accumulation in 3T3-L1 adipocytes, and exhibited significant anti-inflammatory activity through inhibiting superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils.

TL;DR: The structures show that the tail end of the sulfonamide inhibitor is critical in forming stabilizing interactions that influence tight binding; therefore, for future drug design it is the tail moiety that will ultimately determine isoform specificity.

TL;DR: These multi-targeted hybrid compounds appear as promising lead compounds for the treatment of Alzheimer's disease and show that compounds 7d and 7e improved cell viability in cells treated with Aβ₄₂ peptide.

TL;DR: From the study of all target compounds, compound 20 was the most prominent compound having inhibitory potency even higher than Ko143, the most potent BCRP inhibitor known.

TL;DR: It is found that the replacement of the conserved C-terminal glycine with propargylamine converts SUMO and ubiquitin to highly efficient covalent inhibitors of their cognate cysteine proteases.

TL;DR: Novel fluorescent micelles are able to serve as a highly sensitive pH probe in water and to internalize successfully HeLa and HEK cells and showed cell specificity and significantly higher photostability than that of a pure organic dye label such as BODIPY.

TL;DR: Baylis-Hillman-derived 3-(benzylaminomethyl)coumarins have been treated, sequentially, with chloroacetyl chloride and propargylamine to afford alkynylated coumarins as substrates for Click Chemistry reactions with azidothymidine in the presence of a Cu(I) catalyst.