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Showing papers in "Biorheology in 1991"


Journal ArticleDOI
TL;DR: The origin of the non-Newtonian viscosity of blood was discussed in relation to the viscoelasticity and yield stress of blood.

686 citations


Journal ArticleDOI
TL;DR: It is demonstrated that the cytoplasmic apparent viscosity and elasticity vary continuously, depending on the degree of deformation, due to the inhomogeneous nature of the neutrophil internal structure.

142 citations


Journal ArticleDOI
TL;DR: It is concluded that a direct correlation exists between an increase in deformability and progression of the transformed phenotype from a nontumorigenic cell line into a tumorigenic, metastatic cell line.

140 citations


Journal ArticleDOI
TL;DR: Several non-Newtonian fluids were studied to determine how closely they simulate the flow behavior of human blood and showed large differences in velocity profiles compared to Newtonian fluids.

70 citations


Journal ArticleDOI
TL;DR: Transient deformations of leukocytes (WBCs) were studied during their saltation along post-capillary venous endothelium (EC) in mesentery of the rat to find colchicine treated cells appear to be twice as deformable as cells treated with cytochalesin.

47 citations


Journal ArticleDOI
TL;DR: A semi-empirical model to describe the dependence of apparent viscosity of blood on vessel diameter and vessel discharge hematocrit correlates well with several sets of experimental data and behaves according to the Fahraeus-Lindqvist effect.

44 citations


Journal ArticleDOI
TL;DR: Platelets exposed to elongational stress demonstrated a dose dependent decrease in added ADP-induced aggregation rate and extent of aggregation, and the total platelet volume histogram shifted toward larger particle sizes, suggesting the formation of large aggregates as a result of elongations stress exposure.

28 citations


Journal ArticleDOI
TL;DR: The results suggest that simple Newtonian fluids may be sufficient for in vitro determination of the first order effects to be expected of human blood flow in large vessels having complex geometries and shear rates in or above the range of the present study.

24 citations



Journal ArticleDOI
TL;DR: The present experimental system would be useful in examining the mechanism of blood coagulation based on the interaction between blood and endothelial cells as well as in evaluating endothelial cell functions.

23 citations


Journal ArticleDOI
TL;DR: The geometric features of red blood cells in narrow channels in vivo and in vitro were studied by electron microscopy and an analysis based on the large deformation theory of bending of an elastic sheet was developed to estimate the bending stiffness of the membrane.

Journal ArticleDOI
TL;DR: Results obtained confirm the aggregation effect of dextrans of molecular weights equal or higher than 70,000 dalton and disaggregation effect ofdextran 40,000Dalton on aggregation by dextran of higher molecular weight.

Journal ArticleDOI
TL;DR: It seems that slight rheological alterations reported in some clinical studies are unlikely to cause appreciable flow disruption, as quite marked changes in cell mechanics can occur without loss of ability to circulate.

Journal ArticleDOI
TL;DR: Estimation of the relative importance of the albumin on tissue hydraulic conductivity: in non-cartilaginous tissues with moderate GAG concentrations, tissue levels of albumin can generate flow resistance effects comparable to those of the GAGs, although well less than the flow resistance of these tissues.

Journal ArticleDOI
TL;DR: An unsteady convective diffusion in a synovial fluid of human joints modeled as a power-law fluid is studied using the generalized dispersion model of Gill and Sankara-subramanian and it is shown that the effect of decrease in non-Newtonian parameter is to decrease the dispersion coefficient.

Journal ArticleDOI
TL;DR: A vasomotion activity in the mesentery of anesthetized rabbits were studied by simultaneous measurements of inside diameters at multiple sites in arterioles, precapillaries and their bifurcations, and it was showed that the vasomotions originated from the orifice of precapillary at the bifuriations, spreading downstream in the precAPillary.

Journal ArticleDOI
TL;DR: A correlation exists between the metastatic phenotype of the cell and its ability to detach from normal cells and it is concluded that the detachment of all cell types increased with increasing shear stress.

Journal ArticleDOI
TL;DR: Velocity fields have been measured in models simulating arterial stenoses for continuous and revolution flows and plotting streamlines allows to describe accurately the flow; its quantitative aspect offers advantages with respect to conventional visualization mode.

Journal ArticleDOI
TL;DR: The results show that the therapeutic management of rheological parameters should prove to be a unique and clinically rewarding approach to patients supported by both the Jarvik-7 total artificial heart (TAH) and Novacor left ventricular assist device (LVAD) as a bridge to cardiac transplantation.

Journal ArticleDOI
TL;DR: Both an increase of turbulence intensity and an widening of turbulence spectra may be ascribed to a stiffening of the aortic wall due to an elevation of blood pressure, especially when the blood flow velocity was high.

Journal ArticleDOI
TL;DR: The thixotropic parameters of whole blood from 314 healthy subjects were measured with the modified method by Low shear 30 Rheometer and calculated according Huang's equation and it was found that the levels of fibrinogen and plasma viscosity had a tendency of increasing with aging.

Journal ArticleDOI
TL;DR: The observation that isolated nuclei are less deformable than whole cells, may indicate that their nuclei may protect cancer cells from biomechanical trauma.

Journal ArticleDOI
TL;DR: The total loss of deformability observed with red cells containing parasites of similar or smaller size cannot be explained on these grounds alone, and it is suggested an additional mechanism, such as calcium-induced crosslinking of the red cell cytoskeleton, is suggested.

Journal ArticleDOI
TL;DR: Pulsatility modifies velocity fields and the results obtained in steady flow conditions do not apply to pulsatile jets.

Journal ArticleDOI
TL;DR: The biocompatibility of a material can be considered as the ideally expectable result of its interactions with living tissues with which it is interfaced, and depends upon both its intrinsic properties and the application inWhich it is involved.

Journal ArticleDOI
TL;DR: The differences between Rl and Rlc are proportional to the reciprocal of frequency and, thus, correspond to a rate-independent dissipation and are consistent with a yield stress of 3-6 Pa.


Journal ArticleDOI
TL;DR: A method is developed for effectively eliminating bias in serial microvessel diameter measurements of the guinea pig cochlea, automatically measured using an image analysis system and readily extended to other error distributions.

Journal ArticleDOI
TL;DR: Theoretical analysis of the dead-end filtration indicates that the observed variation of TMP with time is consistent with the assumptions that pore volume decreases proportionally to the filtrate plasma volume.

Journal ArticleDOI
TL;DR: A model of the cardiac cycle which explains the relation between Frank's and Starling's laws is presented.