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Showing papers in "Biotechnology Advances in 2014"


Journal ArticleDOI
TL;DR: This review mainly focuses on pH-sensitive nano-systems, including advances in drug delivery, mechanisms of drug release, and possible improvements in drug absorption, with the emphasis on recent research in this field.

837 citations


Journal ArticleDOI
TL;DR: The key mechanisms involved in plant stress tolerance and the effectiveness of microbial inoculation for enhancing plant growth under stress conditions have been discussed at length in this review.

727 citations


Journal ArticleDOI
TL;DR: The current review provides an overview of the history, chemistry, analogs, and mechanism of action of curcumin.

623 citations


Journal ArticleDOI
TL;DR: The evidence for a role of MAPKs in the context of abiotic stress and ABA signaling is summarized, with a focus on the role of SnRKs.

462 citations


Journal ArticleDOI
TL;DR: This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages.

459 citations


Journal ArticleDOI
TL;DR: This review presents a detailed and critical summary of research on the inhibition of anaerobic processes by specific organic toxicants, inorganic toxicants and in particular, nanomaterials, focusing on the mechanism of their inhibition/toxicity.

450 citations


Journal ArticleDOI
TL;DR: This review examines aspects of oleaginous yeasts not covered in depth in other recent reviews, and proposes standardized terms for units that describe yeast cell mass and lipid production.

380 citations


Journal ArticleDOI
TL;DR: In-situ removal of carboxylic acid by extraction during fermentation is the most popular approach, but recovery of the extractant can easily lead to waste inorganic salt formation, which counteracts the advantage of the in-Situ removal.

379 citations


Journal ArticleDOI
TL;DR: Furanic (5-HMF, furfural) and phenolic compounds were found to be stronger inhibitors of the microbial dark fermentation than the full anaerobic digestion process when using mixed cultures as inoculum.

373 citations


Journal ArticleDOI
TL;DR: Co-culture studies that aim to increase the diversity of metabolites obtained from microbes, with a special emphasis on the multiple methods of performing co-culture experiments, are focused on.

363 citations


Journal ArticleDOI
TL;DR: A review of 3D tumor models employing tissue engineering principles can be found in this article, where the authors highlight the profound differences in responses from 3D in vitro tumors and conventional monolayer cultures.

Journal ArticleDOI
TL;DR: The high microalgal lipid potential is anticipated to force research towards finding effective ways to manipulate biochemical pathways involved in lipid biosynthesis and towards cost effective algal cultivation and harvesting systems, as well.

Journal ArticleDOI
TL;DR: The exciting potential of decellularized cartilage, skeletal muscle, tendon and ligament cell-derived matrices has only recently begun to be explored for ultimate translation to the orthopaedic clinic.

Journal ArticleDOI
TL;DR: Verbascoside is a phenylethanoid glycoside that was first isolated from mullein but is also found in several other plant species as mentioned in this paper, including genetically transformed roots.

Journal ArticleDOI
TL;DR: An overview of membrane materials and membrane processes of interest in microalgae cultivation and processing is provided and discussion about specific aspects of membrane applications in microbial cultivation and harvesting is provided, including membrane fouling.

Journal ArticleDOI
TL;DR: Biodiversity, catalytic properties and key enzymes and pathways of these microbes are summarized, and an analysis of raw material costs suggests that methane- derived diesel fuel has the potential to be competitive with petroleum-derived diesel.

Journal ArticleDOI
TL;DR: This comprehensive review discusses recent advances in understanding the effects of major environmental stresses and the characteristics of various engineering operation strategies on the production of biofuels (mainly biodiesel and bioethanol) using microalgae.

Journal ArticleDOI
TL;DR: Additional sources for horticultural improvement, where JAs might be involved, are defense against nematodes, biocontrol by plant growth promoting rhizobacteria, altered composition of rhizosphere bacterial community, sustained balance between growth and defense, and improved plant immunity in intercropping systems.

Journal ArticleDOI
TL;DR: This review focuses on recent progress in the design, fabrication and physicochemical aspects of chitosan-based self-assembled nanomaterials and their applications in drug delivery of different therapeutic agents.

Journal ArticleDOI
TL;DR: This review reports how tomato was already domesticated by the ancient Incan and Aztec civilizations and how it came to Europe, where its breeding history started, and the different goals of tomato genetic engineering.

Journal ArticleDOI
TL;DR: This review summarizes the existing knowledge on the production and biotransformation of flavonoid glycosides using biotechnology, as well as the impact of glycosylation on flavonoids bioactivity.

Journal ArticleDOI
TL;DR: This review attempts to discuss the physical and chemical barriers of the GIT with particular emphasis on the current approaches employed to overcome these barriers, including the evaluation of other non-parenteral routes of protein and peptide delivery.

Journal ArticleDOI
TL;DR: In the future, it is envisioned that iHLCs will be used as in vitro models of human disease, and in the longer term, provide an alternative cell source for drug testing and clinical therapy.

Journal ArticleDOI
TL;DR: This review briefly summarizes some recent cell biological, molecular and proteomic findings concerning the responses of plant roots to heavy metal ions in the rhizosphere, metal ion-induced reactions at the cell wall-plasma membrane interface, and various aspects of heavy metal ion uptake and transport in plants via membrane transporters.

Journal ArticleDOI
TL;DR: A review of alignments of various cell types and their functionality in different tissues in vivo including muscle and nerve tissues and an overview of recent approaches for engineering cell alignment in vitro is provided.

Journal ArticleDOI
TL;DR: This review summarizes recent key advances in the DNA barcoding of medicinal plant ingredients (herbal materia medica) as a contribution towards safe and efficacious herbal medicines.

Journal ArticleDOI
TL;DR: A phylogenetic tree is constructed and the relationship between taxonomy and acetoin producing ability is revealed for the first time, which will serve as a useful guide for the screening of competitive acetoin producers.

Journal ArticleDOI
Haoran Yu1, He Huang1
TL;DR: An overview of a strategy proven effective in enhancing proteins' thermostability with two steps: predict flexible sites of proteins firstly and then rigidify these sites (RFS) is given.

Journal ArticleDOI
TL;DR: This review provides an update on the different proposed pathways of starch biosynthesis occurring in both autotrophic and heterotrophic organs, and provides emerging information about the networks regulating them and their interactions with the environment.

Journal ArticleDOI
TL;DR: This review focuses on the transduction of second messenger and hormone signals by MAPK modules in plant abiotic stress responses and how this crosstalk regulates gene expression and other cellular and physiological responses to enable adaptation and/or resistance to abiotic stresses.