Showing papers in "Biotechnology Advances in 2020"

TL;DR: In this review, flavonoids as classical examples of secondary metabolites are employed to highlight recent advances in understanding how valuable compounds can be regulated at various levels.

TL;DR: Different strategies that could be used to enhance the nutritional content, productivity, and organoleptic traits of algae to help drive development of this new crop are described.

TL;DR: This work reviews applications of high added value molecules produced from microalgae and proposes to linkmicroalgae phyla and related potential applications through highlighting of which bioactive compounds can be found in which phyla.

TL;DR: The structural properties and modification technologies of mRNA are described, the latest advances in developing mRNA delivery systems are summarized, the preclinical and clinical applications are reviewed, and the views on the prospect and challenges of developing mRNA into a new class of drug are put forward.

TL;DR: This review systematically analyze the preclinical studies of curcumin in CVDs such as cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke and diabetic cardiovascular complications.

TL;DR: This review summarizes the gene therapy drugs approved worldwide from 1998 to 2019 in details, including names, indications, dates of approval, companies, vectors, the applied technologies and mechanisms of gene Therapy drugs, etc.

TL;DR: This review evaluates recent advances in the development of phytochemical oral delivery systems, including microemulsions, nanoemulsion, emulsion, solid lipid nanoparticles, liposomes, and biopolymer microgels.

TL;DR: How advanced chemical, biotechnological and computational molecular biology methods can be used for robust exploitation of bioactive compounds from these microorganisms is focused on.

TL;DR: An overview of various technologies of biological nitrogen removal including nitrification, denitrification, anaerobic ammonium oxidation (anammox), as well as bioelectrochemical systems and microalgal growth for nitrogen recovery are presented.

TL;DR: The natural and unique ability of fungi to invade substrates by using enzymes that have the capacity to detoxify pollutants and are able to act on nonspecific substrates is described, the fungal ability to produce hydrophobins for surface coating to attach hyphae to hydrophobic substrates, and hyphal ability to penetrate three dimensional substrates.

TL;DR: This review explores the use of biomaterials derived from naturally occurring ECM proteins and their derivatives in approaches that aim to regulate cell function, and focuses primarily on recent advances in the fields of soft tissue, cardiac, and dermal repair.

TL;DR: The evaluation of biological PU degradation, including the required analytics, is reviewed to provide a critical overview and support future studies.

TL;DR: Current progress in BC fibre manufacturing, its downfalls and also gives a future perspective on how the landscape should change to allow BC to be utilised in wound care in the current environment are summarized.

TL;DR: A comprehensive review of the recent advances and emerging trends of paper-based POC immunoassays, including the fundamental components and work principles, various detection mechanisms and applications, and existing commercialized devices/products are presented.

TL;DR: This review discusses B and BA structures and derivatives and comprehensively explain their pharmacological effects in relation to various diseases, and discusses the delivery methods, in which these compounds most effectively target different systems.

TL;DR: The "pros" and "cons" of using RNAi technology mediated by dsRNA-expressing transgenic plants (host-induced gene silencing, HIGS) or direct application of chemically synthesized ds RNA to control plant-damaging insects are reviewed.

TL;DR: Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented.

TL;DR: Overall, clinical data on phytochemicals against CRC are still not sufficient and therefore the preventive impacts of dietary phytochemistryicals on CRC development deserve further research so as to provide additional insights for human prospective studies.

TL;DR: The future is very bright for transgenic algae with increased biomass yield, carbon dioxide uptake rate, accumulating high-value compounds, reduction in cultivation, and production costs, thus reaching the goal in the global algal market and capital flow.

TL;DR: An overview of the known physiological and molecular mechanisms behind the compounds that induce molecular priming are provided, together with a survey of approaches to discover and functionally study new stress-alleviating chemicals.

TL;DR: It is argued that recent developments signify that pharmaceutical molecular farming is now climbing the slope of enlightenment and will soon emerge as a mature technology.

TL;DR: It is intent to conclude that the production cost of astaxanthin from Haematococcus might be substantially reduced to the levels comparable to that of chemical astrix through further R&D and the future research might need to focus on strain selection and improvement, cultivation process optimization, innovation of cultivation methodologies, and revolution of extraction technologies.

TL;DR: Examples illustrate how modified enzymes can revolutionize future-oriented applications ranging from the bioproduction of bulk-, specialty- and fine chemicals, active pharmaceutical ingredients and carbohydrates, over the conversion of the greenhouse-gas CO2 into valuable products and biocontrol in agriculture, to recycling of synthetic polymers and recovery of precious metals.

TL;DR: This review comprehensively discussed the recent application of defined microbial consortia in the fields of human health monitoring and medicine exploitation, valuable compounds synthesis, consolidated bioprocessing of lignocellulosic materials and environmental bioremediation.

TL;DR: The most critical aspects of PPB-based production and valorisation processes are addressed, including the identification of the main challenges and potentials of different growth strategies and a critical analysis of the production of value-added compounds.

TL;DR: Consolidated bio-saccharification (CBS), a consolidated bioprocessing (CBP) derived strategy, is herein proposed for lignocellulose bioconversion by integrating enzyme production and hydrolysis steps but separating fermentation from the integrated process.

TL;DR: The aim of this review is to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.

TL;DR: This review provides a historical perspective on approved biotherapeutics by regulatory bodies which pave the way for next-generation products (including gene therapy) and focuses on the application of in vitro and in vivo cell line engineering approaches.

TL;DR: An overview of keratin biomass as an enzyme substrate and a systematic analysis of currently sequenced keratinolytic enzymes and their classification and reaction mechanisms are contributed.

TL;DR: The major strategies that are used to enhance the electroactivity and specific functionality of microorganisms pertaining to both anodic and cathodic processes of METs are presented.