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JournalISSN: 0006-4971


About: Blood is an academic journal. The journal publishes majorly in the area(s): Transplantation & Bone marrow. It has an ISSN identifier of 0006-4971. Over the lifetime, 90150 publication(s) have been published receiving 4613373 citation(s). more

Topics: Transplantation, Bone marrow, Population more

Open accessJournal ArticleDOI: 10.1182/BLOOD-2016-03-643544
19 May 2016-Blood
Abstract: The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemias, largely derived from gene expression analysis and next-generation sequencing that can significantly improve the diagnostic criteria as well as the prognostic relevance of entities currently included in the WHO classification and that also suggest new entities that should be added. Therefore, there is a clear need for a revision to the current classification. The revisions to the categories of myeloid neoplasms and acute leukemia will be published in a monograph in 2016 and reflect a consensus of opinion of hematopathologists, hematologists, oncologists, and geneticists. The 2016 edition represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition. The major changes in the classification and their rationale are presented here. more

5,255 Citations

Open accessJournal ArticleDOI: 10.1182/BLOOD.V87.6.2095.BLOODJOURNAL8762095
Charles A. Dinarello1Institutions (1)
15 Mar 1996-Blood
Abstract: To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how production of the different members of the IL-1 family is controlled, the various biologic activities of IL-1, the distinct and various functions of the IL-1 receptor (IL-1R) family, and the complexity of intracellular signaling. Mice deficient in IL-1Beta, IL-1Beta converting enzyme, and IL-1R type I have also been studied. Humans have been injected with IL-1 (either IL-1alpha or IL-1beta) for enhancing bone marrow recovery and for cancer treatment. The IL-1-specific receptor antagonist (IL-1Ra) has also been tested in clinical trials. The topics discussed in this review include production and activities of IL-1 and IL-1Ra molecules, the effects of IL-1 on gene expression, functions of cell-bound and soluble IL-1 receptors, the importance of the IL-1R accessory protein, newly discovered signal transduction pathways, naturally occurring cytokines limiting IL-1 production or activity, the effects of blocking cyclooxygenase and nitric oxide, and the outcomes of IL-1 and IL-1 Ra in human trials. Special attention is paid to IL-1beta converting enzyme and programmed cell death. The roles of IL-1 in hematopoiesis, leukemia, atherosclerosis, and growth of solid tumors are also discussed. This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references. At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease. more

4,214 Citations

Open accessJournal ArticleDOI: 10.1182/BLOOD-2016-01-643569
Steven H. Swerdlow1, Elias Campo2, Stefano Pileri3, Nancy L. Harris4  +7 moreInstitutions (9)
19 May 2016-Blood
Abstract: A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms. more

4,057 Citations

Journal ArticleDOI: 10.1182/BLOOD-2009-03-209262
30 Jul 2009-Blood
Abstract: has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities—some defined principally by genetic features—that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes. (Blood. 2009;114:937-951) more

4,004 Citations

No. of papers from the Journal in previous years

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Journal's top 5 most impactful authors

Hagop M. Kantarjian

1.3K papers, 66.1K citations

Jorge E. Cortes

923 papers, 37.6K citations

Guillermo Garcia-Manero

641 papers, 14.1K citations

Susan O'Brien

604 papers, 31.8K citations

Farhad Ravandi

477 papers, 10.5K citations

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