Showing papers in "Blood in 1999"

TL;DR: In this paper, the authors sequenced the Ig V(H) genes of the tumor cells of 84 patients with CLL and correlated their findings with clinical features, finding that the lack of somatic mutation and trisomy 12 was associated with a less favorable prognosis.

TL;DR: In this paper, cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL) cases for which Ig V(H) and V(L) gene sequences were available.

TL;DR: T HE NADPH OXIDASES are a group of plasma membrane–associated enzymes found in a variety of cells of mesodermal origin found in professional phagocytes and B lymphocytes.

TL;DR: Two different types of membrane vesicles are released after stimulation of platelets with thrombin receptor agonist peptide SFLLRN or -thrombin: microvesicles of 100 nm to 1 μm, and exosomes measuring 40 to 100 nm in diameter, similar in size as the internal vesicle in MVBs and -granules.

TL;DR: The elucidation of the molecular basis of acute promyelocytic leukemia emerged as a paradigm for the connection between the bench and bedside and it became apparent that APL was, among the forms of acute myeloid leukemia, uniquely sensitive to all

TL;DR: A GVL effector and engraftment facilitating mechanism, which is independent of T-cell-mediated GVH reactions, may be operational in HLA mismatched hematopoietic cell transplants.

TL;DR: It is demonstrated that FN-mediated adhesion confers a survival advantage for myeloma cells acutely exposed to cytotoxic drugs by inhibiting drug-induced apoptosis, which may explain how some cells survive initial drug exposure and eventually express classical mechanisms of drug resistance such as MDR1 overexpression.

TL;DR: The FLT3 gene mutation, whose presence is detectable only by genomic polymerase chain reaction amplification and gel electrophoresis, might serve as an important molecular marker to predict the prognosis of patients with AML.

TL;DR: It is strongly suggest that early addition of chemotherapy to ATRA and maintenance therapy combining continuous CT and intermittent ATRA can reduce the incidence of relapse in APL.

TL;DR: It is shown that the API2 gene, encoding an inhibitor of apoptosis also known as c-IAP2, HIAP1, and MIHC, and a novel gene on 18q21 characterized by several Ig-like C2-type domains, named MLT, are recurrently rearranged in the t(11;18).

TL;DR: E efficacy in patients with relapsed fludarabine-resistant B-CLL was poor and different infusion schedules and/or combination regimens with chemotherapeutic drugs to reduce tumor burden before treatment with rituximab will have to be evaluated.

TL;DR: Time-dependent covariate analysis suggested that timely application of a second transplant extended both EFS and OS significantly, independent of cytogenetics and beta-2-microglobulin.

TL;DR: It is recommended that ATRA be used as first choice for remission induction in newly diagnosed APL cases, whereas As2O3 can be either used as a rescue for relapsed cases or included into multidrug consolidation/maintenance clinical trials.

TL;DR: It is concluded that factors associated with altered immunity and T-cell regulatory mechanisms are predictors of both early- and late-onset PTLD.

TL;DR: Findings indicate that the progression of plasma cell tumors is accompanied by an increase of bone marrow neovascularization, which is dependent, at least in part, by FGF-2 and MMP-2 production.

TL;DR: MDR1 is less frequent in younger AML patients, which may in part explain their better response to therapy and neither MRP1 nor LRP are significant predictors of outcome in this patient group, so inclusion of MDR1-modulators alone may benefit younger AMl patients with MDR 1(+) disease.

TL;DR: Multivariate analysis identified ALK expression and the International Prognostic Index as independent variables that were able to predict survival among T/null primary, systemic anaplastic large-cell lymphoma.

TL;DR: Ascorbic acid enhanced the antilymphoma effect of As2O3 in vivo without additional toxicity, and may provide a novel therapy for lymphoma.

TL;DR: The detection of vital tumor by 18F-FDG PET after the end of treatment has a higher predictive value for relapse than classical CT scan imaging (positive predictive value: 100% v 42%).

TL;DR: The results emphasize the importance of lineage-specific chimerism analysis to successfully manipulate engraftment after nonmyeloablative allogeneic PBSC transplantation.

TL;DR: It is shown that the ability of As2O3 to induce apoptosis in leukemic cells is dependent on the activity of the enzymes that regulate cellular H2O2 content, and NB4 cells have relatively low levels of glutathione peroxidase (GPx) and catalase and have a constitutively higher H 2O2content than U937 monocytic leukemia cells.

TL;DR: It is concluded that ALCL is a heterogeneous disorder, however, ALK protein expression is an independent predictor of survival and serves as a useful biologic marker of a specific disease entity within the spectrum of ALCL.

TL;DR: The ability of Epo to interact directly with endothelial cells and to elicit an angiogenic response in vitro and in vivo is demonstrated and thus acts as a bona fide directAngiogenic factor.

TL;DR: These findings provide the first direct and definitive evidence of a deeply but reversibly quiescent subpopulation of leukemic cells in patients with CML with both in vitro and in vivo stem cell properties.

TL;DR: It is demonstrated that IL-10–treated DC induce an antigen-specific anergy in cytotoxic CD8+ T cells, a process that might be a mechanism of tumors to inhibit immune surveillance by converting DC into tolerogenic antigen-presenting cells.

TL;DR: It is demonstrated that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3(+, CD4(+), and CD8(+) T-cell populations when compared with pediatric recipients of unrelated B MT and adults after related BMT, and that these adults have a significantly increased risk of life-threatening opportunistic infections.

TL;DR: Findings demonstrate that the chemokine receptor CXCR4 on CLL B cells plays a critical role for heterotypic adherence to marrow stromal cells and provide a new mechanism to account for the marrow infiltration by neoplastic B cells.

TL;DR: In a dose escalation study, 40 patients with relapsed or refractory CD33 + acute myeloid leukemia (AML) were treated with an immunoconjugate (CMA-676) consisting of humanized anti-CD33 antibody linked to the potent antitumor antibiotic calicheamicin this paper.

TL;DR: It is proposed that HIF-1 may be involved in modulating gene expression during inflammation, as it is found that cytokine-induced inhibition of EPO production is not mediated by impairment of Hif-1 function.

TL;DR: It is shown that CD34 expression reflects the activation state of hematopoietic stem cells and that this is reversible, and activated stem cells express CD34.