Showing papers in "Blood in 2006"

TL;DR: The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.

TL;DR: The results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role.

TL;DR: Striking differences in incidence patterns by histologic subtype strongly suggest that there is etiologic heterogeneity among lymphoid neoplasms and support the pursuit of epidemiologic analysis by subtype.

TL;DR: Recommendations for revisions of some of the initial response criteria for evaluating clinically significant responses in myelodysplastic syndromes are presented.

TL;DR: The combination of a poor performance status and advanced age identified a group of patients with a very high likelihood of dying within 30 days of initiating induction therapy, arguing for age-specific assessments when evaluating therapies for AML.

TL;DR: Suggestions are made for harmonizing the differing methodologies for measuring BCR-ABL transcripts in patients with CML undergoing treatment and using a conversion factor whereby individual laboratories can express BCR -ABL transcript levels on an internationally agreed scale.

TL;DR: Observations reveal that CXCR4 is an important molecule involved in the spread and progression of a variety of different tumors, and that CxCR4 antagonists, although initially developed for treatment of AIDS, actually may become effective agents for the treatment of neoplastic disease.

TL;DR: A subset of cases with a predominating myeloid gene expression signature had more favorable baseline characteristics and superior prognosis to those lacking this signature, suggesting that this signature is linked to disease progression.

TL;DR: It is found that MM cells have a lower threshold for PI-induced UPR induction and ER stress-induced apoptosis because they constitutively express ER stress survival factors to function as secretory cells.

TL;DR: It is shown that MSCs sharply inhibit IL-2-induced proliferation of resting NK cells, whereas they only partially affect the proliferation of activated NK cells.

TL;DR: In this paper, a gain-of-function MPL mutation, MPLW515L, was described in patients with JAK2V617F-negative myelofibrosis with myeloid metaplasia (MMM).

TL;DR: Earlier data is discussed in the context of recent findings in T(reg)-cell biology with a particular emphasis on CD4(+)CD25(high)FOXP3(+) T(Reg) cells in human malignancies.

TL;DR: It is shown that inflammation is induced after transection of the tail of zebrafish larvae and that this inflammation subsequently resolves over a similar time course to mammalian systems.

TL;DR: The CYP2C19*2 loss-of-function allele is associated with a marked decrease in platelet responsiveness to clopidogrel in young healthy male volunteers and may therefore be an important genetic contributor to clopsinogrel resistance in the clinical setting.

TL;DR: The data suggest that altered transcriptional regulation of genes mapping to chromosome 1 may contribute to disease progression, and that expression profiling can be used to identify high-risk disease and guide therapeutic interventions.

TL;DR: The diagnosis of anemia is an important aspect of the practice of hematology and unless earlier blood counts are available, the physician must make his or her decision on the basis of the population distribution of hemoglobin values.

TL;DR: This report shows that the inflammatory cytokine interleukin-6 (IL-6) directly regulates hepcidin through induction and subsequent promoter binding of signal transducer and activator of transcription 3 (STAT3).

TL;DR: The MIPI as discussed by the authors is the first prognostic index particularly suited for mantle cell lymphoma patients and may serve as an important tool to facilitate risk-adapted treatment decisions in patients with advanced stage MCL.

TL;DR: TNF has a novel action in modulating autoimmunity, by inhibiting CD4+CD25+ Treg activity, through signaling through TNFRII that is constitutively expressed selectively on unstimulated Tregs and that is up-regulated by TNF.

TL;DR: Resting NK cells were induced to secrete tumor necrosis factor alpha and interferon gamma and to kill target cells by engagement of specific, pair-wise combinations of receptors, revealing distinct and specific patterns of synergy among receptors on resting NK cells.

TL;DR: Whether in vitro angiogenesis is an miRNA-regulated process is addressed and large-scale analysis of miRNA expression in human umbilical vein endothelial cells found that 15 highly expressed miRNAs have the receptors of angiogenic factors as putative targets.

TL;DR: The molecular basis of the aberrant immune response and deficiencies in hematopoietic cells is now being defined genetically; examples are telomere repair gene mutations in the target cells and dysregulated T-cell activation pathways.

TL;DR: Matched related allogeneic transplantations for ALL in first complete remission provide the most potent antileukemic therapy and considerable survival benefit for standard-risk patients, but the transplantation-related mortality for high-risk older patients was unacceptably high and abrogated the reduction in relapse risk.

TL;DR: The findings support the clinical evaluation of low-dose IL-2 to selectively modulate CD4+CD25+ Tregs and increase expression of FOXP3 in vivo.

TL;DR: For prediction of PFS, interim FDG-PET was as accurate after two cycles as later during treatment and superior to computerized tomography (CT) at all times and in regression analyses, early interimFDG- PET was stronger than established prognostic factors.

TL;DR: It is revealed that patients having only an NPM1 mutation had a significantly better overall and disease-free survival and a lower cumulative incidence of relapse and the analysis of the clinical impact in 4 groups revealed this mutation appears to identify patients with improved response toward treatment.

TL;DR: In this article, the gene expression profile of TAMs isolated from a murine fibrosarcoma in comparison with peritoneal macrophages (PECs) and myeloid suppressor cells (MSCs), using a cDNA microarray technology, was characterized.

TL;DR: The presentation, the response to therapy, and the outcome of the disease are influenced by the genotype, which will translate into improved management and therapy of patients and will provide the way to design tailored treatments.

TL;DR: Examination of in vivo immunomodulatory properties of MSCs in murine models of allogeneic bone marrow (BM) transplantation indicates thatallogeneic MSC’s are not intrinsically immunoprivileged and that under appropriate conditions, allogeneIC M SCs induce a memory T-cell response resulting in rejection of anAllogeneic stem cell graft.