Showing papers in "Bone in 2004"

TL;DR: There is a clear need for the development of more sensitive risk assessment tools, using not only BMD, but also other clinical predictors of fractures.

TL;DR: It is concluded that previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by measurement of BMD.

TL;DR: The Platelet concentration required for a positive PRP effect on bone regeneration seems to span a very limited range, and advantageous biological effects seem to occur when PRP with a platelet concentration of approximately 1,000,000/microl is used.

TL;DR: The literature is summarised of the novel antiosteoporotic drug strontium ranelate, which appears to act by a combination of reduced bone resorption and increased uptake of calcium into bone.

TL;DR: It is shown that adiponectin and the receptors are expressed in primary human osteoblasts from femur and tibia, and the findings suggest a functional role in bone homeostasis.

TL;DR: Test data demonstrate that appropriate combinations of soluble and biomaterial-mediated regulatory signals in cell-based tissue engineering systems can result in both more efficient and more effective tissue regeneration.

TL;DR: It was found that increasing mineralization, increasing crystallinity and increasing type-B carbonate substitution were significantly correlated with decreasing elastic deformation capacity with age, which concludes that the measure of bone mass needs to be supplemented with measures reflecting the physicochemical status of mineral crystals for improved assessment of fracture susceptibility.

TL;DR: A parental history of fracture (particularly a family history of hip fracture) confers an increased risk of fracture that is independent of BMD, and its identification on an international basis supports the use of this risk factor in case-finding strategies.

TL;DR: It is speculated that an alternate strategy to protect human bones from fracture may be through targeting of the periosteum, either using current or novel agents.

TL;DR: Results are compatible with the view that bone development is driven by muscle development, although the data do not exclude the hypothesis that the two processes are independently determined by genetic mechanisms.

TL;DR: The results indicate that the effects of altered leptin signaling on bone differ significantly between axial and appendicular regions, and may be mediated in part by muscle mass.

TL;DR: In this paper, the authors describe bone loss of the separate compartments of trabecular and cortical bone, as well as changes in bone geometry of a large number of spinal cord injured (SCI) individuals.

TL;DR: It is infer that only a small proportion of risk reduction in vertebral and nonvertebral fractures observed with anti-resorptive drug therapy is explained by the increase in BMD, and further studies are needed to define the structural basis of the fracture risk reduction.

TL;DR: A school-based, high-impact exercise intervention implemented three times a week for 12 min is an effective strategy for site-specific gains in bone strength at the narrow neck region of the proximal femur.

TL;DR: It is concluded that MEPE promotes renal phosphate excretion and modulates mineralization in mice following intraperitoneal administration of Hu-MEPE.

TL;DR: Fractured samples, rinsed to remove mineral plates, reveal separated collagen fibrils on the fractured surfaces, providing important insights into the nanostructured architecture of this complex biocomposite.

TL;DR: In this paper, the authors measured the strength and stiffness of calcaneus bone samples taken at autopsy from 20 subjects (aged 78 +/- 8 years, 8 women, 12 men) who died suddenly without apparent bone disease.

TL;DR: A new method is shown that can detect and track changes in the local bone architecture and individual trabeculae in time, in an individual living animal and has the potential to greatly contribute to experimental rat or mouse studies on pharmacological intervention and transgenic models.

TL;DR: Although these results are still preliminary, transplantation of osteoblast-like cells and PRP, which seemed to be a safe and minimally invasive cell therapy, could shorten the treatment period by acceleration of bone regeneration during distraction osteogenesis.

TL;DR: Findings show that sclerostin selectively controls the apoptosis of bone cells, providing a novel level of control in the regulation of bone formation.

TL;DR: This study identifies a distinct group of patients with hypovitaminosis D and a blunted PTH response who show a disruption in calcium homeostasis but protected against PTH-mediated bone loss and has clinical implications with respect to disease definition.

TL;DR: The ex vivo crack-initiation and crack-growth toughness are determined and are found to deteriorate with age; the initiation toughness decreases some 40% over 6 decades from 40 to 100 years, while the growth toughness is effectively eliminated over the same age range.

TL;DR: It is shown that FGF23 is likely to be cleaved by subtilisin-like proprotein convertases (SPC) as cleavage can be inhibited by a specific SPC inhibitor in HEK293 cells as well as in osteoblasts.

TL;DR: It is concluded that Wnt signaling inhibits dexamethasone-induced osteogenesis in hMSCs, and release of Wnt3A or lithium from porous calcium phosphate scaffolds to the proliferative phase of osteogenesis is limited.

TL;DR: It is shown, for the first time, that the surface roughness of Ti has a profound effect on the profile of genes expressed by bone cells and suggest that improvements in the biological activity and possibly the clinical efficacy of these materials could be achieved by selective regulation of gene expression mediated via modification of surfaceroughness.

TL;DR: This research presents a novel and scalable approach to providing real-time information about the immune system’s response to chemotherapy and its effects on survival and quality of life.

TL;DR: The results strengthen the paradigm of a strong relationship between bone morphology and external loads applied during normal daily life and indicate that vertebral fractures result from actions like forward flexion or lifting, loads that may not be "daily" but are normally not traumatic either.

TL;DR: The unifying hypothesis that larger muscles induced by exercise led to a proportional increase in bone mass, bone size, and bending strength appears to be simplistic and denies the influence of other factors in the development of bone mass and bone shape.

TL;DR: In this article, the authors presented experimental evidence supporting crack bridging, rather than microcracking, as the most significant mechanism of toughening in cortical bone and dentin.

TL;DR: This study has generated transgenic mice utilizing a mouse DMP1 cis-regulatory system to drive GFP as a marker for living osteocytes and examined the expression of DMP-1 mRNA in murine marrow stromal and calvarial osteoblast cultures, and in bone, andCalvaria in vivo.