Showing papers in "Bone in 2007"

TL;DR: The RANKL signaling pathway has promise as a strategy for suppressing the excessive osteoclast formation characteristic of a variety of bone diseases and is controlled by an epigenetic mechanism, which has profound implications for the general mechanism of irreversible cell fate determination.

TL;DR: The pleiotropic effects of intermittent PTH, each of which alone may increase osteoblast number, may explain why this therapy reverses bone loss in most osteoporotic individuals regardless of the underlying pathophysiology.

TL;DR: The dual threshold method offers a robust and fully-automated alternative to the gold standard that can efficiently segment bone regions with accurate and repeatable results.

TL;DR: Although weight-bearing exercise appears to enhance bone mineral accrual in children, particularly during early puberty; it remains unclear as to what constitutes the optimal exercise programme.

TL;DR: This model would explain why bone resection is unhelpful in managing this problem, suggests that low bone turnover caused by non-bisphosphonate drugs should not cause the same problem, and raises the possibility that agents which reverse bisph phosphonate effects in vitro might have a role in the management of ONJ.

TL;DR: The results indicate that advanced glycation end products, which accumulate in diabetic and aged individuals, may promote apoptosis of osteoblastic cells and contribute to deficient bone formation.

TL;DR: Overexpression of several functional-domain mutants of BSP demonstrated that increases in osteoblast-related gene expression and matrix mineralization observed in BSP overexpression models are mediated by the integrin-binding RGD motif found near the C-terminus of the protein.

TL;DR: Results indicate that temporary exposure of MSCs to hypoxia leads to limited stimulation of angiogenic factor secretion but to persistent down-regulation of several osteoblastic markers, which suggests that exposure ofMSCs transplanted in vivo to Hypoxia may affect their bone forming potential.

TL;DR: IL-6 -/- mice had delayed callus maturity, mineralization, and remodeling compared with the callus of the wildtype mice, indicating that the role of IL-6 appears to be most important in the early stages of fracture healing.

TL;DR: It is shown that cancellous bone is susceptible to NEG that increases its propensity to fracture and may be susceptible to an age-related accumulation of AGEs.

TL;DR: The results are consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly and suggest that autocrine, and perhaps paracrine, pathways of vitamin D(3) metabolism may regulate key osteoblast functions independently of circulating, kidney derived 1,25D.

TL;DR: Results show that a MSC reservoir is present in tissues other than BM and fat, and that MSCs of different origin have similar neural differentiation potential, which provides new insights into BM-like tissue plasticity and may have important implications for future therapeutic interventions in chronic neuropathies.

TL;DR: The present quantitative exposition shows DXA-measured in vivo "BMD" methodology to be an intrinsically flawed and misleading indicator of bone mineral status and an erroneous gauge of relative fracture risk.

TL;DR: The scope of this review is limited to presenting a picture of the available knowledge on bone densitometry in pediatrics, and the literature on fractures will be presented in detail, since fractures are one of the key elements in the debate.

TL;DR: The data suggest that FGF23 expression in bone is closely correlated with bone formation in vitro and vivo, and points towards an important role(s) for FGF 23 in young adult but not fetal mineralized tissues as a systemic factor for Pi homeostasis.

TL;DR: The osteocyte appears to be more responsive to PFF than the osteoblast or periosteal fibroblast regarding to the production of soluble factors affecting osteoclast formation and bone resorption.

TL;DR: Average losses of bone mineral after long-duration spaceflight ranged between 2% and 9% across all sites with the recovery model predicting a 50% restoration of bone loss for all sites to be within 9 months.

TL;DR: It is demonstrated that the shape of the BMDD histogram of trabecular bone reflects directly the mineralization kinetics, and the described theoretical framework opens new possibilities for an analysis of experimentally measured BMDDs with respect to changes caused by diseases or treatments.

TL;DR: The results show the importance of considering regional variations in cancellous BAPs and disc health when assessing fracture risk, and good correlations between BV/TV, connective density and yield strength are found.

TL;DR: While age was the most important factor, sex and body size were found to play a role in parameters related to canal size and the overall level of porosity in 3D remodeling-related change in the structure of cortical bone porosity across the human lifespan.

TL;DR: Despite an increase in the population at risk and in the mean age of hip fractured women, there was a significant decrease in age-adjusted incidence in women but not in men, which may suggest a reversal of the previously observed secular trend.

TL;DR: In a population of home-dwelling healthy postmenopausal women with few of them with severe vitamin D deficiency, vitamin D status may not be an important determinant of bone health.

TL;DR: The findings of modest but statistically significant beneficial effects of statins on hip BMD should promote large double-blind randomized controlled trials on their bone effects, in view of their major beneficial cardiovascular effects with excellent safety profile.

TL;DR: DKK1 is a negative regulator of normal bone homeostasis in vivo and manipulation of DKK1 function or expression may have therapeutic significance for the treatment of low bone mass disorders.

TL;DR: 3-D micro-CT measurements (longitudinal) are comparable to those of standard histomorphometry, and that most of the bone structural measurements are sensitive to changes in women's hormonal status across menopause.

TL;DR: It is concluded that increased microdamage accumulation may occur in low BMD patients treated with alendronate, and femoral neck BMD was the only independent predictor for these correlations.

TL;DR: It is concluded that patients can be switched from oral ALN to ZOL 5 mg infusion with maintenance of therapeutic effect for at least 12 months and that patients prefer a once yearly infusion to weekly oral therapy.

TL;DR: Histomorphometric analysis of unpaired iliac crest bone biopsies in postmenopausal osteoporotic patients treated with strontium ranelate showed that the drug increased bone formation, assessed by both the mineralization rate and osteoblast surface, and tended to decrease the osteoclastsurface, compared with the placebo group.

TL;DR: FGF23 is a hormone that regulates serum phosphate level in contrast to other FGF family members that work as local factors and requires Klotho for its signaling in addition to a canonical FGF receptor.

TL;DR: The stimulatory effect of PTH peptides on bone formation may favour their use in low turnover bone disease and in states of advanced bone loss, and if beneficial effects on cortical bone strength are confirmed, efficacy at non-vertebral sites might be superior to those observed with antiresorptive drugs.