Showing papers in "Bone in 2008"
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TL;DR: The study of osteocyte biology is becoming an intense area of research interest and this review will examine some of the recent findings that are reshaping the understanding of bone/bone cell biology.
989 citations
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TL;DR: This paper proposes that the reference standard should be based on bone mineral density (BMD) measurement made at the femoral neck with dual-energy X-ray absorptiometry (DXA), which has been the most extensively validated, and provides a gradient of fracture risk as high as or higher than that of many other techniques.
927 citations
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TL;DR: In vitro assays performed on primary murine bone cells confirmed the dual action of strontium ranelate in vivo as an anabolic agent on bone remodeling, which stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization.
735 citations
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TL;DR: BMDD measurements combined with other scanning techniques like nanoindentation, Fourier transform infrared spectroscopy and small angle X-ray scattering can provide important insights into the structure-function relation of the bone matrix, and ultimately a better prediction of fracture risk in diseases, and after treatment.
600 citations
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TL;DR: The results indicate that delivery of both growth factors may enhance bone bridging and union of the critical size defect compared to delivery of BMP-2 alone and suggests an interplay between these growth factors for early bone regeneration.
545 citations
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Harvard University1, University of Pennsylvania2, University of Sheffield3, Cincinnati Children's Hospital Medical Center4, Northwestern University5, University of Nebraska Medical Center6, Shriners Hospitals for Children7, University of Wisconsin-Madison8, Columbia University9, University of British Columbia10, University of Geneva11
TL;DR: This is a review of the methodology of the PDCs and selected ISCD Official Positions.
530 citations
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TL;DR: In postmenopausal women with low BMD, long-term denosumab treatment led to gains in BMD and reduction of BTM throughout the course of the study, and the effects on bone turnover were fully reversible with discontinuation and restored with subsequent retreatment.
496 citations
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TL;DR: The combined numerical-experimental procedure for FE model validation on the patient micro-CT technology demonstrated that bone strength can be estimated non-invasively, and this may provide important insight into fracture risk in patient populations.
423 citations
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TL;DR: The data suggest that mechanical loading decreases the osteocyte's potential to induce osteoclast formation by direct cell-cell contact, and conclude that osteocytes may function as mechanotransducers by regulating local osteOClastogenesis via soluble signals.
312 citations
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TL;DR: It appears that TBS permits to accurately differentiate between two 3D microarchitectures that exhibit the same amount of bone, but different trabecular characteristics, which may lead to using TBS measurements directly on DXA images obtained in routine clinical practice.
299 citations
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TL;DR: The data demonstrate that estrogen deficiency enhances the production of the pro-osteoclastogenetic cytokines TNFalpha and RANKL and increases the number of circulating OC precursors, and it is shown that T cells and monocytes from women with osteoporosis exhibit a higher production of TNF alpha than those from the other two groups.
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TL;DR: The results suggest increased osteoconductive outcomes with an increase in initial content of apatite and BMP-2 in the silk fibroin porous scaffolds provided enhanced outcomes for the bone tissue engineering.
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TL;DR: An extended bone-cell dynamics model describing functional behaviour of basic multicellular units (BMUs) responsible for bone resorption and formation is formulated and it is found that there is a preferred arrangement for ligand expression on particular cell types, and that this arrangement coincides with biological observations.
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TL;DR: It is demonstrated that osteoblasts may also contribute to the pathogenesis of the disease, either because they are affected by intrinsic defects, or because their activity may be enhanced by deregulated osteoclasts abundantly present in most forms, thus suggesting additional genetic/environmental determinants affecting penetrance.
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TL;DR: Regular walking has no significant effect on preservation of BMD at the spine in postmenopausal women, whilst significant positive effects at femoral neck are evident, however, diverse methodological and reporting discrepancies are apparent in the published trials.
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TL;DR: The results suggest that the presence of US-tubes may render nanocomposite scaffolds bioactive assisting osteogenesis, and the in vivo biocompatibility ofUS-tube reinforced porous biodegradable scaffolds in a rabbit model is reported on.
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TL;DR: Hip fracture mainly affects elderly women and presents great variability in incidence, seasonality, length of hospital stay and mortality between the different autonomous regions in Spain.
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TL;DR: The anisotropy of osteocytes and their alignment to the local mechanical loading condition suggest that these cells are able to directly sense matrix strains due to external loading of bone, and suggests an additional mode of mechanosensing besides interstitial fluid flow.
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TL;DR: The results acknowledge crystal properties as an important bone quality factor and raise the possibility that aberrations in these properties may contribute to senile osteoporotic fractures.
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TL;DR: Osteoclasts are able to take up large amounts of BP, due to their ability to release the BP from the dentine surface during resorption, and non-resorbing cells take up only small amounts ofBP that becomes available due to natural desorption from the Dentine surface.
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TL;DR: A potential side effect associated with bisphosphonates, a class of drugs used in the treatment of osteoporosis, Paget's disease and metastatic bone disease, is osteonecrosis of the jaw (ONJ).
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TL;DR: It was found that active adolescent males had 8-10% more adjusted BMC at the TB, TH and FN (p<0.05) in young adulthood and that active adolescents females had 9% and 10% more adjustments at the TH andFN.
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TL;DR: When the energy status of exercising women was adequate (replete), there were no apparent perturbations of bone formation or resorption, regardless of estrogen status, and the importance of avoiding energy deficiency, which is associated with hypoestrogenism, is underscored.
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TL;DR: This tutorial considers the many techniques for evaluating toughness and assess their specific relevance and application to the mechanical testing of small animal bones and determines the coefficient of variation of the measured toughness values.
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TL;DR: Clinical use of bisphosphonates as an adjuvant therapy for giant cell tumor of bone demonstrated a lower local recurrence rate and the clinical response seems to be more promising in stage III diseases.
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TL;DR: Strontium ranelate increases the replication of cells of the osteoblastic lineage by two distinct cellular mechanisms, which may directly interact with the CaSR and trigger mitogenic signals such as p38 in C3H10T1/2 cells.
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TL;DR: Bone microhardness measured by Vickers indentation is an interesting methodology for the evaluation of bone strength and its determinants at the BSU level, but the organic matrix accounts for about one third of its variance.
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TL;DR: Relationship between phosphate and FGF23 indicated that TIO and XLH are diseases with high F GF23 and hypophosphatemia judged by age-dependent reference ranges for serum phosphate, which establishes the diagnosis of diseases caused by excess actions of FGF 23.
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TL;DR: Serum 25(OH)D levels below or equal to 12 ng/ml were associated with an increased fracture risk in persons aged 65-75 years, and this relatively low cut point in this population is possibly caused by high calcium intake in the Netherlands.
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TL;DR: The results of this study indicate that quantifying mobile and bound water with magnetic resonance techniques could potentially serve as indicators of bone quality.