Showing papers in "Bone in 2009"

TL;DR: FRAX integrates the influence of several well validated risk factors for fracture with or without the use of BMD, and poses challenges for patient assessment, the development of practice guidelines, the evaluation of drug efficacy and reimbursement, as well as for health economics.

TL;DR: The invention of an effective and novel technique in obtaining n-HA in cognate with native apatite on electrospun nanofibers within minutes without any pre-treatment to exploit the nano-scale functional and material characteristics of natural bone to modulate cellular functions for optimal bone repair in bone graft systems.

TL;DR: Osteogenic responses to SLActive were moderately better than the hydrophobic SLA surface and gene expression studies indicate that WNT5A activation may be responsible for this increased osteogenic differentiation.

TL;DR: Based on current evidence, the risk of ONJ in osteoporosis appears to be comparable to that in the general population, and it is likely that ONJ results from direct toxicity to cells of bone and soft tissue from high potency bisphosphonates.

TL;DR: The high probability that a detailed understanding of these processes will aid in the development of novel treatments for bone metabolic disorders is highlighted, and the possibility that bone resorption can be attenuated pharmacologically without a secondary reduction in bone formation is discussed.

TL;DR: In isolation of osteocyte and osteoblast cell populations and their subsequent microarray analysis allowed us to identify a number or genes and pathways with potential roles in regulation of bone mass.

TL;DR: Skeletal FGF-23 and DMP1 expression are increased in CKD and are related to skeletal mineralization, suggesting that osteocyte function is altered early in the course of CKD.

TL;DR: Findings indicate that fracture callus mechanical properties can be predicted by several microCT-derived measures of callus structure and composition, and form the basis for developing non-invasive assessments of fracture healing and for identifying biological and biomechanical mechanisms that lead to impaired or enhanced healing.

TL;DR: The literature is revisited and experimental evidence favoring the hypothesis that osteocytes are able to remove and replace the bone matrix according to the systemic needs of the body is discussed, thus providing current views of what is known so far on the ability of osteocytes to mobilize bone mineral.

TL;DR: It is indicated that obesity induced by a high-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice.

TL;DR: Average post-flight proximal femoral strength is greater than forces expected to occur due to falls or normal activities, some subjects have small margins of safety, but some crew members may be at increased risk for age-related hip fractures decades after their missions.

TL;DR: The results suggest that NF-kappaB activation may function in lineage selection during differentiation of hMSCs by fostering osteogenic differentiation at the expense of other differentiation lineages.

TL;DR: Osteoporosis is common in patients with AS and seems to berelated to disease activity while vertebral fractures appear to be related to the duration and structural severity of the disease rather than BMD.

TL;DR: It is suggested that maintenance therapy with lithium carbonate may preserve or enhance bone mass and suggest a lower bone turnover state in those receiving lithium.

TL;DR: Data suggest that bone necrosis precedes clinical onset and is an inflammation-associated process, and it is hypothesized that from an initial focus, bone damage spreads centrifugally, both deeper into the jaw and towards the mucosa before the oral bone exposure and the clinical diagnosis of ONJ.

TL;DR: The results indicate that beam hardening artifacts of up to 32.6% can occur in sample sizes of interest in studies investigating mineralized tissue and affect mineral density measurements and that microCT can be an accurate tool for murine bone densitometry.

TL;DR: Osteoporotic rod-like trabeculae showed decreases in Young's modulus, fracture load, yield strength, ultimate stress, work to failure and bending stiffness, along with significantly increased mean calcium content and calcium width, while non-osteoporosis iliac crests and vertebrae displayed linear dependency on structure parameters, whereas osteoporotics compartments proved to be non-correlated with bone structure.

TL;DR: Targeting Wnt signaling in a selective and tissue specific manner is an exciting opportunity for the development of disease modifying drugs for osteoarthritis.

TL;DR: Bazedoxifene (20 and 40 mg doses combined) significantly decreased the risk of all clinical fractures and morphometric vertebral fractures in women at or above a FRAX based fracture probability threshold.

TL;DR: The differences in 3D morphology of osteocytes and their lacunae in long bones of different pathologies with different BMD might reflect an adaptation to matrix strain due to different external loading conditions.

TL;DR: The bone formation markers PINP, PICP and OC show a rapid and robust increase in response to teriparatide, which is noticeable during the first week of therapy, and may inform the design of studies of new anabolic agents for osteoporosis.

TL;DR: Tibial bone strength indicators seemed to be related to exercise-specific peak forces, whilst cortical density was inversely related to running distance.

TL;DR: It is demonstrated that participation in an eight week physical training program that incorporates a resistance component by previously inactive young women results in alterations in biomarkers of bone remodeling indicative of increased formation without substantial alterations in markers of resorption.

TL;DR: The results indicate that GLP-2 produces a substantial decrease in bone resorption without suppression of bone formation thereby changing the bone remodeling balance in favor ofBone formation, particularly at the hip.

TL;DR: The impact of diabetes-induced oxidative stress in the development of diabetic bone disorder is focused on and it is demonstrated that both streptozotocin-induced diabetic mice and spontaneously diabetic Torii rats, an animal model of type 2 diabetes, have low-turnover osteopenia associated with increased oxidative stress.

TL;DR: Though no direct measures of bone resorption rate were made, the higher cortical bone quantity is associated with a smaller marrow cavity and increased retention of non-lamellar bone, signs of decreased endocortical resor adaptation.

TL;DR: When vertebrae are compressed naturally by adjacent intervertebral discs, cranial endplates usually fail before caudal endplates because they are thinner and supported by less dense trabecular bone.

TL;DR: The findings suggest that preconceptional and first-trimester use of bisphosphonates may not pose substantial fetal risks.

TL;DR: V in men and urinary C-peptide in women as factors inversely associated with the presence of VFs are identified, suggesting that, of the components of the metabolic syndrome, body fat in gravity and hyperinsulinemia could increase FN-BMD in diabetic subjects.