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Showing papers in "Brain Research in 1972"


Journal ArticleDOI
TL;DR: The purpose of the present study was to reinvestigate the role of the central retinal projections in neuroendocrine regulation and find that lesions in the suprachiasmatic region of the hypothalamus abolish the constant estrous response to light in the female rat.

2,062 citations


Journal ArticleDOI
TL;DR: There are several reasons for thinking that this method may offer a number of advantages over other currently available techniques, and it should be possible to do this by locally injecting radioactively labeled precursors of proteins or other macromolecules into the brain or spinal cord.

1,523 citations


Journal ArticleDOI
TL;DR: The glial fibrillary acidic (GFA) protein, a brain specific protein extracted from severely gliosed human tissue, is not species specific; cross-reaction occurs between anti-human GFA protein antibodies and brain extracts of rabbit, guinea pig, rat and dog.

1,449 citations


Journal ArticleDOI
Masao Ito1
TL;DR: To develop this approach toward understanding the operation of cerebellar neuronal machinery, the Vestibulo-cerebellum and its relation with the vestibuloocular reflex arc has been chosen since the neuronal construction of this system is probably the simplest among the Cerebellar-controlled motor systems.

555 citations


Journal ArticleDOI
TL;DR: The uptakes of glutamic and aspartic acids were mutually competitive in both cerebral cortical and spinal cord preparations, suggesting that they utilize the same uptake mechanism.

465 citations


Journal ArticleDOI
TL;DR: An intense band of acetylcholinesterase developed in the molecular layer of the dentate gyrus exactly where the entorhinal fibers normally terminate, and this layer develops over a period of 30–40 days and is eliminated by septal lesions, which cause the disappearance of the normal bands of acetylene.

461 citations


Journal ArticleDOI
TL;DR: The role played by thyroid hormone in the initiation of cell differentiation in the central nervous system is discussed and mechanisms of differentiation of cells derived from the external granular layer are discussed.

450 citations



Journal ArticleDOI
TL;DR: The monoamine-containing neurones of the newborn could take up the amine precursors, and react to reserpine and nialamide in the same way as in the adult, and were biochemically differentiated before completion of their morphological development.

388 citations



Journal ArticleDOI
TL;DR: It is suggested that the use of autoradiography in conjunction with radioactively labelled amino acids may constitute a valuable method for localising the neurones which use these substances as neurotransmitters in the mammalian CNS.

Journal ArticleDOI
TL;DR: Injections of [3H]leucine were stereotaxically placed in the red nucleus of cats, and the ascending and descending rubral projections were traced by following the transport of isotopically labeled protein from red nucleus cell bodies to their terminals.

Journal ArticleDOI
TL;DR: The angles of the joints of the hindlimb and the electromyographical activity of the hinderlimb muscles were recorded during locomotion in mesencephalic and thalamic cats.



Journal ArticleDOI
TL;DR: Auditory evoked potentials to ‘clicks’ were averaged from the scalps of litters of anesthetized rat pups and kittens throughout neonatal development, consistent with the hypothesis that significant limitations in both the immature and mature auditory system, as measured by peak latencies, occur before the VIIIth nerve.


Journal ArticleDOI
TL;DR: A comparison of the amino acid levels in focal and surrounding tissue of the same patient demonstrated that the focal area most often contained the lowest concentrations of glutamic acid, aspartic acid and taurine in combination with the highest glycine content.



Journal ArticleDOI
TL;DR: It is proposed that the system of dopamine-containing neurones from the ventral mesencephalic tegmentum is one of two systems whose activation will support self-stimulattion responding.



Journal ArticleDOI
TL;DR: Brodmann's areas 3 and 1 of the hand area of the classical somatosensory cortex of Macaca mulatta were systematically mapped using a microelectrode multiunit recording technique to reveal the hand is totally represented in each of these two areas.

Journal ArticleDOI
TL;DR: The glial cell Na+ K+-ATPase was always more active, and markedly more sensitive to variations in the K+ ion concentration than the neuronal ATPase, which support the idea that control of the extracellular K- ion concentration in the CNS is at least in part dependent on the metabolically coupled sodium-potassium pump of the glia.

Journal ArticleDOI
TL;DR: The results indicate that the enzyme tryptophan hydroxylase and the uptake mechanism for 5-HT are predominantly, if not uniquely, associated with terminals of the raphe system.

Journal ArticleDOI
TL;DR: The depolarization of motoneurones by dl -homocysteate was not altered by changes in intracellular chloride concentration, or extracellular concentrations of tetrodotoxin sufficient to suppress spike generation, and the action of the amino acid thus probably resembles that of synaptically released excitatory transmitters.

Journal ArticleDOI
TL;DR: New information concerning the circadian rhythms in 5-HT synthesis and utilization is provided and new aspects of the processes of the regulation of 5- HT metabolism in central serotoninergic neurones are discovered.

Journal ArticleDOI
TL;DR: Results revelent qu'il existe deux systemes de fibres ascendantes issus des neurones pontiques c'est-a-dire le systeme coerulo-cortical et le systema ponto-hypothalamique, yn â’n ôl un neurone unique peut innerver toutes les aires corticales et le thalamus.

Journal ArticleDOI
TL;DR: The activity of vestibulospinal neurons giving axons to the lumbosacral spinal cord was recorded during locomotion in mesencephalic and thalamic cats and periodic alternations of this activity in relation to the locomotor cycle (modulation) were observed in cats with intact cerebellum.