Showing papers in "Brain Research in 1989"

TL;DR: This paper provides the first evidence of such reorganization of a hippocampal seizure focus in human temporal lobe epilepsy (TLE), which involves the selective loss of somatostatin and neuropeptide Y immunoreactive interneurons, and axonal sprouting of other neuropePTide Y neurons and dynorphin-A immunore active granule cells.

TL;DR: It is suggested that the accumulation of abnormally phosphorylated tau is one of the earliest cytoskeletal changes in the process of tangle formation and exposure of certain ubiquitin epitopes in the pathological fibers may reflect an unsuccessful attempt of proteolytic degradation.

TL;DR: Stimulation of mouse astrocytes and microglia in enriched culture by lipopolysaccharide results in the production of a cytotoxic factor that is functionally similar to macrophage-derived tumor necrosis factor-alpha (TNF) and may play a role in certain pathological conditions in the brain.

TL;DR: It is demonstrated that the retrograde transneuronal viral cell body labeling method can be used simultaneously with either neuropeptide transmitter or transmitter synthetic enzyme immunohistochemistry.

TL;DR: The results indicate that auditory association cortex in the human temporal-parietal junction is critical for auditory P3 generation.

TL;DR: The CNS cell groups that innervate the sympathoadrenal preganglionic neurons of rats were identified by a transneuronal viral cell body labeling technique combined with neurotransmitter immunohistochemistry and these results imply there are local interneurons that regulate the sympathetic neurons.

TL;DR: It is proposed that neuronal cell injury in the hippocampus serves as a useful 'window' to assess beneficial efficacy of pharmacological intervention in the treatment of brain injury.

TL;DR: The apparent lack of defense mechanisms against oxidative stress may in part account for the 'fragility' of neurons in culture and the physiological implications of glutathione compartmentation in brain are discussed.

TL;DR: The results suggest that growth in a diffusion-limited space, reduction of oxygen concentration to physiological levels and control of toxic oxidation with physiological antioxidants can greatly improve the survival and neuritogenesis of isolated hippocampal neurons in primary culture.

TL;DR: Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method, suggesting a possible role for zinc in the death of the postsynaptic neurons.

TL;DR: A population of septohippocampal axons alone was found to be immunoreactive for gamma-aminobutyric acid (GABA) following post-embedding immunogold staining of ultrathin sections cut from the same material.

TL;DR: Afferent connections of the medial and lateral prefrontal cortex of the rat arising from the hippocampal formation were investigated using iontophoretic application of the fluorescent tracer, Fluoro-gold to demonstrate that the projection which originates in the temporal part of the CA1 hippocampal field and in the prosubiculum is restricted to the prelimbic area of the prefrontal cortex.

TL;DR: The present data support the hypotheses that the posterior hypothalamus plays a critical role in the mechanisms of W and that sleep might result from functional blockade of the hypothalamic waking center.

TL;DR: Results suggest that HSP72 immunocytochemistry may be used as a marker of cellular injury in the mammalian brain.

TL;DR: Patients with central pain following spinal cord injury fire in bursts of action potentials more frequently than do similar neurons in patients without pain, and the characteristic firing pattern within these bursts is similar to that associated with the occurrence of calcium spikes in intracellular studies of thalamic nuclei.

TL;DR: A mechanism by which D1-dopamine receptor mechanisms may regulate long-term changes in dopaminergic systems is suggested, which is mediated by dopamine receptors in the striatum.

TL;DR: Anterograde tracing with biocytin is successful even in animals that are quite old, in contrast to lectins and HRP conjugates, and offers advantages in delivery, tissue processing, selection of light and/or electron microscopic labels, time to obtain results, and cost over many conventional tracers.

TL;DR: The results suggest that neuronal degeneration in the ganglion cell layer (GCL) should be added to the constellation of neuropathologic changes found in patients with Alzheimer's disease.

TL;DR: The results suggest that endogenous extracellular IGF-I plays an important role during regeneration of peripheral nerve fibers in rats after a crush lesion.

TL;DR: It is concluded that even mild mechanical injury can potentiate selective ischemic hippocampal neuronal necrosis in the absence of overt axonal injury, and this potentiation also occurs in conjunction with more generalized electrophysiological disturbances such as EEG evidence of postischemic neuronal hyperactivity suggesting that mild concussion may also decrease the threshold for post-ischemics neuronal excitation.

TL;DR: The data suggest that prefrontal cortex exerts early inhibitory modulation of input to primary auditory cortex in humans.

TL;DR: The results suggest that the mechanisms underlying the development of sensitization to the locomotor activating effects of amphetamine and intra-VTA morphine are different even though these may ultimately result in similar changes in the activity of mesencephalic DA neurons.

TL;DR: It is concluded that ATP is released from electrically stimulated hippocampal slices from presynaptic nerve terminals in a calcium-dependent fashion and may play a role in the modulation of synaptic efficiency.

TL;DR: The results suggest that postinjury treatment with MgCl2 is effective in limiting the extent of neurological dysfunction following experimental traumatic brain injury in the rat.

TL;DR: Electrophysiological studies with hippocampal slices show that glibenclamide blocks hyperpolarization induced by anoxia, suggesting the involvement of adenosine triphosphate-sensitive K+ channel in this early hyperpolarsization event.

TL;DR: Within the thalamus, noxious stimulation induces immunoreactivity not only in traditionally expected locations, but also within the paraventricular, submedial and reuniens nuclei.

TL;DR: Ethanol may have direct actions on NMDA-receptor activated increases in [Ca2+]i and this increase could be prevented or reversed by the NMDA antagonists Mg2+ (1.0 mM) and 2-amino-5-phosphonovalerate (AP5)

TL;DR: A hemiparkinsonian model in which there is 6-OHDA-induced destruction of the dopaminergic nigrostriatal pathway but sparing of the mesolimbic pathway is created, which more closely approximates the extent of neurodegeneration seen in human idiopathic Parkinson's disease than previous parkinsonian rat models.

TL;DR: The results of the present study indicate that double bouquet cells can be distinguished both by their GABAergic character and by their possession of calbindin immunoreactivity.

TL;DR: This reproducible model is used to examine vascular permeability to horseradish peroxidase (HRP) after injury and found scattered evidence for protein extravasation at the injured site and at sites along the axis of the cord.